Nogo-B fosters HCC progression by enhancing Yap/Taz-mediated tumor-associated macrophages M2 polarization

Zhao, Xiaoping; Wang, Xiaoying; You, Yu; Wen, Diguang; Feng, Zhihao; Zhou, Yun; Que, Keting; Gong, Jianping; Liu, Zuojin

doi:10.1016/j.yexcr.2020.111979

Cited by 34 publications

(26 citation statements)

References 38 publications

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“…Consistently, Li C. et al (2019) demonstrated in vivo that the expression profile of M1 phenotypic proinflammatory factors TNF-α and IL-1β were augmented while M2 characteristic anti-inflammatory factors IL-10 and TGF-β were weakened in myeloid-specific YAP knockout mice. Similar results can be found in tumor-associated macrophages (TAMs) as well (Huang et al, 2017;Jia et al, 2020;Zhao et al, 2020). However, some contrary results with regard to the regulatory effect of YAP in macrophages have been described.…”

Section: Hippo-yap Pathway Regulates Osteoimmunologysupporting

confidence: 60%

Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

Zhou

Liu

et al. 2020

Front. Cell Dev. Biol.

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The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desirable osseointegration and it's increasingly appreciated that Hippo-YAP signaling pathway is implicated in those biological processes both in vitro and in vivo in a variety of study. In this article we review the multiple effects of Hippo-YAP signaling in osseointegration of dental implants by regulating osteogenesis, angiogenesis and osteoimmunology in peri-implant tissue, as well as highlight prospective future directions of relevant investigation.

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Section: Hippo-yap Pathway Regulates Osteoimmunologysupporting

confidence: 60%

Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

Zhou

Liu

et al. 2020

Front. Cell Dev. Biol.

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“…Tumor-associated macrophages (TAMs) majorly facilitate tumor angiogenesis, invasion, and metastasis and lead to a poor prognosis in HCC ( Zhang et al, 2019 ; Zhao et al, 2020 ). There have been studies substantiating that targeting TAMs becomes a potential individualized precision single or combined therapy ( Li et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…Both survival curves and univariate Cox regression analyses suggested that these candidate hub genes have a strong predictive ability for HCC. Previous studies demonstrated that TAMs extremely facilitate tumor angiogenesis and lead to a detrimental prognosis in HCC ( Zhang et al, 2019 ; Zhao et al, 2020 ). The identification of TAM-related genes will facilitate providing more potential targets of the individualized precision treatment and improve the prognosis of HCC.…”

Section: Discussionmentioning

confidence: 99%

Identification of Hub Genes Associated With Immune Infiltration and Predict Prognosis in Hepatocellular Carcinoma via Bioinformatics Approaches

Chen

et al. 2021

Front. Genet.

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AimsIn the cancer-related research field, there is currently a major need for a greater number of valuable biomarkers to predict the prognosis of hepatocellular carcinoma (HCC). In this study, we aimed to screen hub genes related to immune cell infiltration and explore their prognostic value for HCC.MethodsWe analyzed five datasets (GSE46408, GSE57957, GSE74656, GSE76427, and GSE87630) from the Gene Expression Omnibus database to screen the differentially expressed genes (DEGs). A protein–protein interaction network of the DEGs was constructed using the Search Tool for the Retrieval of Interacting Genes; then, the hub genes were identified. Functional enrichment of the genes was performed on the Metascape website. Next, the expression of these hub genes was validated in several databases, including Oncomine, Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and Human Protein Atlas. We explored the correlations between the hub genes and infiltrated immune cells in the TIMER2.0 database. The survival curves were generated in GEPIA2, and the univariate and multivariate Cox regression analyses were performed using TIMER2.0.ResultsThe top ten hub genes [DNA topoisomerase II alpha (TOP2A), cyclin B2 (CCNB2), protein regulator of cytokinesis 1 (PRC1), Rac GTPase-activating protein 1 (RACGAP1), aurora kinase A (AURKA), cyclin-dependent kinase inhibitor 3 (CDKN3), nucleolar and spindle-associated protein 1 (NUSAP1), cell division cycle-associated 5 (CDCA5), abnormal spindle microtubule assembly (ASPM), and non-SMC condensin I complex subunit G (NCAPG)] were identified in subsequent analysis. These genes are most markedly enriched in cell division, suggesting their close association with tumorigenesis. Multi-database analyses validated that the hub genes were upregulated in HCC tissues. All hub genes positively correlated with several types of immune infiltration, including B cells, CD4+ T cells, macrophages, and dendritic cells. Furthermore, these hub genes served as independent prognostic factors, and the expression of these hub genes combing with the macrophage levels could help predict an unfavorable prognosis of HCC.ConclusionIn sum, these hub genes (TOP2A, CCNB2, PRC1, RACGAP1, AURKA, CDKN3, NUSAP1, CDCA5, ASPM, and NCAPG) may be pivotal markers for prognostic prediction as well as potentially work as targets for immune-based intervention strategies in HCC.

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“…Both survival curves and univariate Cox regression analyses suggested that these candidate hub genes have a strong predictive ability for HCC. Previous studies demonstrated that TAMs extremely facilitate tumor angiogenesis and lead to a detrimental prognosis in HCC (Zhang et al, 2019;Zhao et al, 2020). The identification of TAM-related genes will facilitate providing more potential targets of the individualized precision treatment and improve the prognosis of HCC.…”

Section: Discussionmentioning

confidence: 99%

“…Tumor-associated macrophages (TAMs) majorly facilitate tumor angiogenesis, invasion, and metastasis and lead to a poor prognosis in HCC (Zhang et al, 2019;Zhao et al, 2020).…”

Section: The Overexpression Of Hub Genes Accompanied By a High Level mentioning

confidence: 99%

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Nogo-B fosters HCC progression by enhancing Yap/Taz-mediated tumor-associated macrophages M2 polarization

Cited by 34 publications

References 38 publications

Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology

Identification of Hub Genes Associated With Immune Infiltration and Predict Prognosis in Hepatocellular Carcinoma via Bioinformatics Approaches

Table_1.xlsx

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