Nog eens 't Suydt Hollantsche Thessalia van L. van Bos

Praag, J.A. van

doi:10.1007/bf01536224

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“…The standard probenecid technique involves the measurement of the relevant metabolites in the lumbar CSF before administration of probenecid and 4 h after the last dose of probenecid. Van Praag et al (1973) have shown that the accumulation of 5-HIAA and HVA in 38 depressive patients was significantly smaller when compared with 12 normal subjects. Comparable results were 180S J.D.…”

Section: Introductionmentioning

confidence: 89%

“…Studies by van Praag and others have shown that the turnover of DA in depressive patients may be lowered in particular, when motor inhibition (fcor example, psychomotor inhibition, retardation and apthy) are prominent (Korf & van Praag,197 la, van Praag et al, 1973). L-DOPA, a substance which, in the brain, is converted mainly into DA, has a therapeutic effect in these patients-in particular, where motor pathology is concerned (Goodwin et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

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Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.

Vanscheyen¹,

Vanpraag²,

Korf³

1977

Brit J Clinical Pharma

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ICentral dopamine turnover may be lowered in patients withl unipolar endogenous depression. particularly when associated with retardation. 2 Nomifensine selectively activates the central dopaminergic system and may be of special therapeutic value in patients with motor inhibition. 3 A double-blind comparison of clomipramine and nomifensine was carried out in patients with recurrent unipolar depression. Biochemical and clinical assessments were carried out weekly for 4 weeks. 4The mean homovanillic acid level in cisternal liquor of those pattients who respondcd to nomifensine, was significantly lower than the mean level of the total group. 5 The factor 'retardation' on the Hamilton Depression Scale was improved more with nomifensine than with clomipramine.

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%