Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya, Nikhil J.; Seeger, Christian; Babai, Norbert; Gonzalez‐Lozano, Miguel A.; Mack, Volker; Lodder, J.C.; Gouwenberg, Yvonne; Mansvelder, Huibert D.; Danielson, U. Helena; Li, Ka Wan; Heisenberg, Martin; Spijker, Sabine; Frischknecht, Renato; Smit, August B.

doi:10.1016/j.celrep.2018.06.102

Cited by 31 publications

(34 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Noelin-1 knockout mice display abnormal social- and anxiety-related behaviors and impaired olfaction, increased resting and activity-induced calcium concentrations in the hippocampus and olfactory bulbs, and upregulated calcium-dependent signaling pathways; however, AMPAR function was unaffected [ 392 ]. Consistently, Pandya and colleagues recently showed that Noelin-1 did not influence AMPAR channel properties [ 395 ]. On the contrary, Noelin-1 regulates the lateral mobility and interaction with the extracellular matrix of AMPARs, in a subunit-specific manner: increasing Noelin-1 amounts in hippocampal neurons affects both synaptic and extrasynaptic GluA1-containing AMPARs, but only extrasynaptic GluA2-containing AMPARs.…”

Section: Noelinmentioning

confidence: 62%

“…Noelin isoforms play important roles during various stages of the development of the neural system and head structure [ 388 – 391 ]. Regarding plasticity, both Noelin-1 and 2 have also been shown by independent studies to interact directly with AMPARs [ 10 , 392 – 395 ]. Noelin-1 interacts with additional AMPAR auxiliary subunits, such as TARP γ8 and neuritin; in addition, Noelin-1, 2, and 3 are able to form heterodimers and have a similar expression pattern, suggesting the possible coexistence of multiple Noelin isoforms within a given AMPAR complex [ 394 , 395 ] (Fig.…”

Section: Noelinmentioning

confidence: 99%

“…On the contrary, Noelin-1 regulates the lateral mobility and interaction with the extracellular matrix of AMPARs, in a subunit-specific manner: increasing Noelin-1 amounts in hippocampal neurons affects both synaptic and extrasynaptic GluA1-containing AMPARs, but only extrasynaptic GluA2-containing AMPARs. This suggests that additional auxiliary subunits are involved in regulating the lateral mobility of synaptic GluA2-containing AMPARs [ 395 ]. In zebrafish double knockout for olfactomedin1 a/b, the homologs of Noelin-1, levels of synaptic AMPARs are significantly reduced; as GluA2 palmitoylation is decreased (but phosphorylation unaffected), this suggests that Noelin-1 regulates GluA2 maturation and thereby trafficking from the ER to the dendritic compartment, a role not mutually exclusive with regulating AMPAR lateral mobility [ 393 ] (Fig.…”

Section: Noelinmentioning

confidence: 99%

See 2 more Smart Citations

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking

Bissen

Foss

Acker‐Palmer

2019

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated. In glutamatergic neurons, synaptic strength is controlled by the number and function of AMPA receptors at the postsynapse, which mediate most of the fast excitatory transmission in the central nervous system. Their trafficking to, at, and from the synapse, is, therefore, a key mechanism underlying synaptic plasticity. Intensive research over the last 20 years has revealed the increasing importance of interacting proteins, which accompany AMPA receptors throughout their lifetime and help to refine the temporal and spatial modulation of their trafficking and function. In this review, we discuss the current knowledge about the roles of key partners in regulating AMPA receptor trafficking and focus especially on the movement between the intracellular, extrasynaptic, and synaptic pools. We examine their involvement not only in basal synaptic function, but also in Hebbian and homeostatic plasticity. Included in our review are well-established AMPA receptor interactants such as GRIP1 and PICK1, the classical auxiliary subunits TARP and CNIH, and the newest additions to AMPA receptor native complexes.

show abstract

Section: Noelinmentioning

confidence: 62%

Section: Noelinmentioning

confidence: 99%

Section: Noelinmentioning

confidence: 99%

See 1 more Smart Citation

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking

Bissen

Foss

Acker‐Palmer

2019

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…It binds a range of secreted proteins and cell surface-bound receptors for induction of cell signalling processes and its structure has been described in detail [142]. Noelin also plays important roles in synaptic plasticity [143]. It is also related to growth and metastasis suppression of colorectal cancer [144] and linked to epithelial-mesenchymal transition in the chick embryonic heart [145].…”

Section: Discussionmentioning

confidence: 99%

Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds

Phillips

Kraev

Lange

2020

Biology

View full text Add to dashboard Cite

Pelagic seabirds are amongst the most threatened of all avian groups. They face a range of immunological challenges which seem destined to increase due to environmental changes in their breeding and foraging habitats, affecting prey resources and exposure to pollution and pathogens. Therefore, the identification of biomarkers for the assessment of their health status is of considerable importance. Peptidylarginine deiminases (PADs) post-translationally convert arginine into citrulline in target proteins in an irreversible manner. PAD-mediated deimination can cause structural and functional changes in target proteins, allowing for protein moonlighting in physiological and pathophysiological processes. PADs furthermore contribute to the release of extracellular vesicles (EVs), which play important roles in cellular communication. In the present study, post-translationally deiminated protein and EV profiles of plasma were assessed in eight seabird species from the Antarctic, representing two avian orders: Procellariiformes (albatrosses and petrels) and Charadriiformes (waders, auks, gulls and skuas). We report some differences between the species assessed, with the narrowest EV profiles of 50–200 nm in the northern giant petrel Macronectes halli, and the highest abundance of larger 250–500 nm EVs in the brown skua Stercorarius antarcticus. The seabird EVs were positive for phylogenetically conserved EV markers and showed characteristic EV morphology. Post-translational deimination was identified in a range of key plasma proteins critical for immune response and metabolic pathways in three of the bird species under study; the wandering albatross Diomedea exulans, south polar skua Stercorarius maccormicki and northern giant petrel. Some differences in Gene Ontology (GO) biological and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for deiminated proteins were observed between these three species. This indicates that target proteins for deimination may differ, potentially contributing to a range of physiological functions relating to metabolism and immune response, as well as to key defence mechanisms. PAD protein homologues were identified in the seabird plasma by Western blotting via cross-reaction with human PAD antibodies, at an expected 75 kDa size. This is the first study to profile EVs and to identify deiminated proteins as putative novel plasma biomarkers in Antarctic seabirds. These biomarkers may be further refined to become useful indicators of physiological and immunological status in seabirds—many of which are globally threatened.

show abstract

“…A recently identified member of the Shisa family, Shisa7, is important for hippocampal glutamatergic synaptic plasticity as well as contextual memory (15). Noelin1, expressing a secreted glycoprotein at synapses in an activitydependent manner, reduces lateral mobility of both synaptic and extrasynaptic AMPARs and affects short-term plasticity (16). Synaptotagmin-3, an integral membrane protein of synaptic vesicles that is not required for learning, mediates AMPAR internalization in an activity-induced way to weaken synapse strength and mediate forgetting (17).…”

mentioning

confidence: 99%

Retrieval-Driven Hippocampal NPTX2 Plasticity Facilitates the Extinction of Cocaine-Associated Context Memory

Wang¹,

Jin²,

Le³

et al. 2020

Biological Psychiatry

View full text Add to dashboard Cite

BACKGROUND: Postretrieval extinction attenuates the pathological memory associated with psychiatric states such as drug addiction in both humans and rodents. The extinction of a learned response requires gene transcription and protein synthesis after memory retrieval in a time-dependent manner, yet the precise physiological basis after retrieval to allow extinction to neutralize a learned behavior is not fully understood. METHODS: In a cocaine conditioned place preference paradigm, we used a ribosomal tagging strategy to measure the translational state of hippocampal pyramidal neurons after the retrieval of cocaine-associated context memory. Using approaches of electrophysiology, neuronal tracing, and a doxycycline-dependent robust activity marking system, we investigated the cellular and molecular basis of retrieval-induced plasticity that facilitated the extinction. RESULTS: Bioinformatics analysis discovered the specific translational regulation of signaling pathways by retrieval and revealed Nptx2 as the hub gene. Manipulating Nptx2 in dorsal hippocampus bidirectionally regulated the extinction of cocaine-associated context memory as well as the retrieval-driven synaptic remodeling. The pentraxin (PTX) domain of NPTX2 recruited GluA1-AMPA receptors and enhanced the extinction and excitatory synaptic transmission that was prevented by overexpressing carboxyl cytoplasmic tail of GluA1. Furthermore, Nptx2 in retrieval-activated neurons was required for the extinction. CONCLUSIONS: The retrieval-driven upregulation of Nptx2 contributes to the synaptic remodeling in dorsal hippocampus and facilitates the extinction of cocaine-associated context memory, indicating a potential target for the treatment of cue-induced cocaine seeking.

show abstract

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Cited by 31 publications

References 51 publications

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking

Protein Deimination and Extracellular Vesicle Profiles in Antarctic Seabirds

Retrieval-Driven Hippocampal NPTX2 Plasticity Facilitates the Extinction of Cocaine-Associated Context Memory

Contact Info

Product

Resources

About