Nodular sclerosing adenosis detected as focal uptake on molecular breast imaging

Axmacher, Jessica A; Bhatt, Asha A; Hesley, Gina K.

doi:10.1016/j.radcr.2020.04.008

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…Magnetic resonance imaging (MRI) is an important examination for breast diseases by virtue of its high-resolution determination of soft tissue ( 8 ). However, it is too expensive and time-consuming to be used as a routine examination for the diagnosis of SA ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Multimodal ultrasound imaging for diagnostic differentiation of sclerosing adenosis from invasive ductal carcinoma

Li,

Zheng,

Liu

et al. 2024

Quant Imaging Med Surg

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Background Sclerosing adenosis (SA) is a common proliferative benign lesion without atypia in the breast that may mimic invasive ductal carcinoma (IDC) on medical imaging, leading to it often being misdiagnosed and mistreated. Consequently, the purpose of this study was to assess the diagnostic value of multimodal ultrasound imaging in distinguishing SA from IDC. Methods Multimodal ultrasound imaging, including automated breast volume scan (ABVS), elasticity imaging (EI), and color Doppler flow imaging (CDFI), were performed on 120 consecutive patients comprising 122 breast lesions (54 SA, 68 IDC). All lesions were pathologically confirmed. Multimodal ultrasound imaging features were compared between the two groups. Binary logistic regression analysis based on ABVS, EI, and CDFI was conducted to formulate a logistic regression equation for differentiating SA from IDC. The diagnostic performances of ABVS, EI, CDFI, and their combination were compared by the receiver operating characteristic (ROC) curve analysis. Results The sensitivity, specificity, and accuracy of ABVS, EI, CDFI, and their combination in differentiating SA from IDC were, respectively, 75.00%, 72.22%, and 73.77%; 86.76%, 72.22%, and 80.33%; 73.53%, 64.81%, and 69.67%; and 88.24%, 74.07%, and 81.97%. Combining multimodal ultrasound imaging yielded an area under the curve (AUC) of 0.895 (95% confidence interval: 0.827–0.943), which was higher than that of ABVS, EI, and CDFI, with AUC values of 0.736, 0.795, and 0.692, respectively, and the difference was statistically significant (ABVS vs. combined model, P<0.001; CDFI vs. combined model, P<0.001; EI vs. combined model, P<0.001). There was no significant difference in the diagnostic efficacy among the three imaging modalities (ABVS vs. EI, P=0.266; ABVS vs. CDFI, P=0.4671; EI vs. CDFI, P=0.051). Compared with those in IDC, the calcification (16.67% vs. 57.35%; P<0.001) and retraction phenomena in the coronal planes (18.52% vs. 57.35%; P<0.001) were less common in patients with SA, while circumscribed margin (38.89% vs. 5.88%; P<0.001), vascularity grade 0–I (64.81% vs. 26.47%; P<0.001), and elasticity scores 1–3 (72.22% vs. 13.24%; P<0.001) were more frequently found in patients with SA. Patients with SA were significantly younger than were patients with IDC (43±11 vs. 54±11 years; P<0.001), and the lesion size was smaller in patients with SA than in those with IDC (median size 1.0 cm; interquartile range (IQR), 0.9 cm vs. median size 1.3 cm; IQR, 1.3 cm; P<0.001). Conclusions The preliminary results suggested that multimodal ultrasound imaging can imp...

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Section: Introductionmentioning

confidence: 99%

Multimodal ultrasound imaging for diagnostic differentiation of sclerosing adenosis from invasive ductal carcinoma

Li,

Zheng,

Liu

et al. 2024

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

“…It can mimic malignancy both radiologically and microscopically. [3][4][5][6][7][8] FDG PET/CT findings of the sclerosing adenosis have been rarely reported. This case indicates sclerosing adenosis can show increased FDG uptake and should be included in the differential diagnosis of focal breast FDG accumulation along with nonmalignant and malignant conditions, including gynecomastia, 9 mastitis, 10 fat necrosis, 10 fibroadenoma, 10,11 intraductal papilloma, 10 atypical ductal hyperplasia, 10 breast carcinoma, 10,12 angiosarcoma, 13 lymphoma, 14,15 and metastasis.…”

mentioning

confidence: 99%

“…It occurs most commonly in the perimenopausal period. It can mimic malignancy both radiologically and microscopically 3–8 . FDG PET/CT findings of the sclerosing adenosis have been rarely reported.…”

mentioning

confidence: 99%