Nodular Sarcoidosis Masquerading as Cancer

Sweidan, Alexander J; Singh, Navneet; Stein, Alexander; Tanios, Maged

doi:10.1177/1179548417703123

Cited by 12 publications

(8 citation statements)

References 23 publications

(14 reference statements)

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“…Quando esta síndrome se apresenta, a especificidade diagnóstica é superior a 95%, 2 no entanto, apesar do elevado valor preditivo positivo da clínica, 3,10 perante a evidência de um quadro constitucional com dispneia e nódulos pulmonares, iniciamos a marcha diagnóstica com exclusão das principais hipóteses diagnósticas descritas. 11,12 A pesquisa de BK no lavado broncoalveolar e o IGRA foram negativos, o que excluiu tuberculose. Foi também excluída a hipótese de se tratar de uma vasculite, pois a doente tinha ANA e ANCA negativos e eletromiografia sem alterações.…”

Section: Discussionunclassified

Apresentação Típica de uma Variante Rara da Sarcoidose

Bertão

Costa

Baptista

et al. 2021

Gaz Med

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A síndrome de Löfgren é uma forma de apresentação aguda da sarcoidose que ocorre em até metade dos indivíduos com esta doença. O seu diagnóstico é mais frequente em mulheres caucasianas até aos 35 anos. Caracteriza-se pela tríade: eritema nodoso, linfadenopatias hilares bilaterais e poliartralgias.A sarcoidose nodular trata-se de uma variante rara da sarcoidose cujo padrão, por mimetizar outras patologias, atrasa o diagnóstico de sarcoidose.Descrevemos o caso de uma mulher caucasiana, de 30 anos, que recorreu ao Serviço de Urgência por edema dos membros inferiores e artralgias com seis dias de evolução. Analiticamente, apresentava elevação dos parâmetros inflamatórios, da velocidade de sedimentação e anemia. Radiografia torácica com alargamento dos hilos. A tomografia computorizada do tórax mostrou vários nódulos mediastínicos, hilares e pulmonares.Apresentamos a marcha diagnóstica de uma variante rara de sarcoidose com uma apresentação clínica típica.

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Section: Discussionunclassified

Apresentação Típica de uma Variante Rara da Sarcoidose

Bertão

Costa

Baptista

et al. 2021

Gaz Med

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“…Lung cancer must be excluded to confirm the diagnosis of pulmonary sarcoidosis [4]. There have been many reports of pulmonary sarcoidosis misdiagnosed as lung cancer [9][10][11]. While rare, the coexistence of pulmonary sarcoidosis and lung cancer has been reported [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Delayed diagnosis of lung cancer due to misdiagnosis as worsening of sarcoidosis: a case report

et al. 2020

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Background: The concurrence of sarcoidosis and primary lung cancer is very rare. We report a very rare case with a delayed diagnosis of primary lung cancer due to its misdiagnosis as worsening of pulmonary sarcoidosis. Case presentation: A 68-year-old man presented to the outpatient department for evaluation of a mass in the right hilar area with lymphadenopathies in subcarinal and both interlobar areas on chest computed tomography (CT). Sufficient core samples were obtained from subcarinal and bilateral interlobar lymph nodes using endobronchial ultrasonography (EBUS) guided transbronchial needle aspiration (TBNA). EBUS could not reach the right hilar lymph node due to its high angle. The pathologic findings were consistent with sarcoidosis. After 5 months, chest CT revealed aggravation of the right upper paratracheal lymphadenopathy. Assuming worsening of sarcoidosis, he was prescribed an oral corticosteroid for 5 months. However, follow-up chest CT showed a newly developed right lower paratracheal lymphadenopathy and worsening right hilar lymphadenopathy. Bronchoscopy and EBUS were performed once again. Transbronchial lung biopsy from the right upper lobe and EBUS-TBNA from the right lower paratracheal lymph node revealed adenocarcinoma from the lung. Conclusions: Although coexistence of sarcoidosis and lung cancer is very rare, the clinician should consider the possibility of accompanying lung cancer in sarcoidosis patients who are not responding to initial corticosteroid therapy.

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“…Nodular sarcoidosis represents a rare atypical form of pulmonary sarcoidosis, with an incidence of 1.6–4% [ 2 ]. Due to its limited incidence and reporting, little is known about nodular sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis presenting as a solitary pulmonary mass

Mulkareddy

Bhalla

Gurell

2020

Respiratory Medicine Case Reports

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Sarcoidosis has a wide varying presentation. Pulmonary sarcoidosis typically presents with bilateral hilar adenopathy and reticulonodular opacities. Very rarely it can present as a single solitary mass. Here we present a case of a 39 year old African-American male who presented with cough and pleuritic chest pain. Initial imaging revealed a right lower lobe airspace opacity, concerning for pneumonia. Despite treatment with antibiotics, symptoms and radiological findings persisted. A PET scan revealed a FDG positive right lower lobe pulmonary mass. Biopsy of the mass and lymph nodes revealed non-caseating granulomas suggestive of sarcoidosis. This case showcases a rare presentation of pulmonary nodular sarcoidosis.

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Nodular Sarcoidosis Masquerading as Cancer

Cited by 12 publications

References 23 publications

Apresentação Típica de uma Variante Rara da Sarcoidose

Apresentação Típica de uma Variante Rara da Sarcoidose

Delayed diagnosis of lung cancer due to misdiagnosis as worsening of sarcoidosis: a case report

Sarcoidosis presenting as a solitary pulmonary mass

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