Nodular Regenerative Hyperplasia of the Liver: An Unusual Cause of Portal Hypertension in Childhood

Nodular Regenerative Hyperplasia Associated with Idiopathic Thrombocytopenic Purpura in a Young Girl: A Case Report and Review of the Literature

“…Other pediatric reports have been associated with congenital heart disease (9,10), Krabbe disease (5), Still's disease (21), chronic inflammation (7), sacrococcygeal teratoma (22), autoimmune disorder (3) and multiple organ malformation in fetuses (4).…”

“…It is a benign proliferative process in which the normal hepatic architecture is entirely replaced by diffuse regenerative nodules of hepatocytes (2). Nodular regenerative hyperplasia occurs predominantly in older patients (2) however there are some reports of NRH in children (3)(4)(5)(6)(7)(8)(9)(10)(11). A number of systemic diseases and drugs have been reported in association with NRH: myeloproliferative syndromes, lymphoproliferative syndromes, chronic vascular disorders, Felty's syndrome, polyarteritis nodosa, scleroderma, calcinosis cutis, Raynaud's phenomenon, sclerodactyly and telangiectasia, lupus erythematosus, and use of steroids or antineoplastic medication (1).…”

Nodular Regenerative Hyperplasia of the Liver in a 4-Month-Old Infant

“…[1][2][3][4][5][6]19 Hématologie disorders associated with NRHL include polycythemia vera,1,5,6 multiple myeloma,6 chronic lymphocytic leukemia,8 lymphocytic lymphoma,1 Hodgkin's disease,1 macroglobulinemia,8 and lymphomatoid granulomatosis.7 Other malignancies in this list include carcinomas of the mouth,1,9 pancreas,1 and colon.1 '7 Despite this wealth of information, we remain basically unenlightened as to the cause and mechanisms that re¬ sult in NRHL. Stromeyer and Ishak,1 in their report, have called attention to the possible role of the drug regimens to which many of these patients are submitted.…”