Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Thyroid

Bello, Carlos Tavares; Cassis, João; Simões, Hélder; Duarte, João Sequeira

doi:10.1155/2016/8756723

Cited by 5 publications

(7 citation statements)

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“…Les LTP représentent moins de 5% de tous les cancers de la thyroïde et jusqu'à 7% de tous les lymphomes extra-ganglionnaires [ 4 , 10 ]. La majorité des lymphomes thyroïdiens sont de type non-hodgkinien avec la prédominance du lymphome diffus à grande cellules B jusqu'à 70% suivi du lymphome B de la zone marginale (MALT) [ 5 ], tandis que LH de la glande thyroïde est extrêmement rare, il représente 0.6-5% de toutes les tumeurs thyroïdiennes et 7% des lymphomes thyroïdiens [ 6 , 11 ]; uniquement une trentaine de cas rapportés dans la littérature [ 12 ]. Le LTP de type hodgkinien, affecte principalement la femme (75-80% de patients) avec un âge médian de 42 ans au moment du diagnostic, comme il a été rapporté par Sa A Wang et al dans une étude de 5 cas [ 13 ] et par P. Sánchez-Velaa et al dans un tableau rassemblant les cas décrit dans la littérature [ 14 ].…”

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“…La plupart des cas rapportés présentaient aussi des adénopathies cervicales. La forme scléro-nodulaire (SN) que présentait notre patient est la forme la plus décrite, suivie de la forme à cellularité mixte [ 14 ], cela peut être expliqué par la prédominance de cette forme et sa tendance bien reconnue dans le médiastin et la région cervicale [ 16 ]; un seul cas rapporté avait la forme lymphocytaire nodulaire du LH [ 12 ], la fibrose et la sclérose étaient aussi décrite [ 13 ]. La plupart des patients rapportés dans la littérature, comme il est le cas pour notre patient, présentaient une maladie à un stade localisé, souvent IIE dans la classification d'Ann-Arbor [ 14 ].…”

Section: Discussionunclassified

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Lymphome de hodgkin primitif de la thyroïde: à propos d'un cas

Hadri¹,

Fares²,

Moutiqui³

et al. 2017

Pan Afr Med J

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Les lymphomes thyroïdiens primitifs sont une entité clinique rare, qui ne dépassent pas 5% des lymphomes diagnostiqués, se produisent plus fréquemment chez les femmes que chez les hommes, avec un pic d'incidence à la sixième décennie de la vie. La relation avec une thyroïdite chronique est bien connue. Le sous type hodgkinien, encore plus rare, peu décrit dans la littérature; posant un problème diagnostique. La confirmation diagnostique est portée le plus souvent sur la pièce opératoire. Pour mieux comprendre cette entité, nous rapportons le cas d'un patient de 64 ans, sans notion de thyroïdite chronique, admis pour un lymphome de Hodgkin de la thyroïde, diagnostiqué sur une masse cervicale antérieure. La thyroïdectomie avec études histopathologique et d'immunohistochimique avaient confirmé le diagnostic. Le patient avait reçu une chimiothérapie de type ABVD (Adriblastine-Bléomycine-Vinblastine-Dacarbazine) et programmé pour une radiothérapie.

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Section: Discussionunclassified

Lymphome de hodgkin primitif de la thyroïde: à propos d'un cas

Hadri¹,

Fares²,

Moutiqui³

et al. 2017

Pan Afr Med J

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“…NLPHL is a rare subtype of HL that accounts for less than 10% of all cases of HL. 4 It has distinctive clinical, histological, and immunophenotypic characteristics that enables easy recognition and distinguishing from cHL. Unlike cHL, NLPHL presents usually in an early stage of the disease and has a male predominance (75%).…”

Section: Introductionmentioning

confidence: 99%

An 18-year population-based study on the epidemiology, clinical features, treatment, and outcome of nodular lymphocyte predominant Hodgkin lymphoma, single center experience in Oman

Wahaibi¹,

Hashmi²,

Siyabi³

et al. 2021

IJPO

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Hodgkin's lymphoma (HL) is a B-cell lymphoma characterized by the presence of Reed-Sternberg cells. HL comprises 1% of all cancer cases and 14% of all lymphoma cases. Nodular lymphocyte predominant HL (NLPHL) is a subtype of HL characterized by a unique clinical and histological presentation. The clinical presentation and survival rate of these patients have not been described in Oman. We, therefore, aimed to describe the clinical characteristics and survival rate of patients with NLPHL. Materials and Methods: This is a retrospective cohort study that was conducted in a tertiary care centers in the Sultanate of Oman. All Omani patients with histopathological confirmed diagnosis of NLPHL from 1998 to 2016 were included in this study. The demographic, clinical, and survival rate were recorded and analyzed. Results: Forty-six histologically confirmed cases of NLPHL were analyzed with a median follow-up of 72 months (range: 12-228 months). Median age at diagnosis was 26.5 years (range: 13−53) and 70% of the patients were male. B symptoms were present in 6% and stage I disease was the most common (39%) presenting stage. Patients were treated with radiotherapy (33%), chemotherapy (37%), combined modality (radiotherapy and chemotherapy) (28%), or careful watch-and-wait (2%). Relapses occurred in twelve (26%) patients after a median of 48 months (24-168 months). Two (4%) patients died during followup due to relapse of NLPHL. Conclusion: This is the first study that demonstrates the demographic, clinical, and survival rate of NLPHL patients in Oman. Our study confirms the male predominance in NLPHL patients. The overall 10-year survival was 96%. The outcome was not significantly different with chemotherapy alone or radiotherapy or combined modality. This study showed higher relapse rate; therefore, further study is needed to validate this observation.

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“…Lymphocytic thyroiditis may be involved in the development of PTL by allowing lymphoid cell infiltration of the thyroid bed. 3 The common histological subtypes are extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) and diffuse large B-cell lymphoma (DLBCL).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study

Chen¹,

Qing²,

Jin³

et al. 2018

CMAR

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ObjectivesFew studies on prognostic indicators for primary thyroid lymphoma (PTL) have been presented due to the uncommon nature of the tumor. This is the first study to explore the independent prognostic factors in the 2 PTL subtypes.MethodsWe retrospectively reviewed 1,653 cases of PTL. The cases comprised 28 Chinese patients from a local cohort and 1,625 patients from the Surveillance, Epidemiology, and End Results database from 1973 to 2013. Statistical analysis was performed to determine the demographics and prognostic factors of PTL patients.ResultsThe disease-specific survival (DSS) and prognostic indicators were significantly different between patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) and patients with diffuse large B-cell lymphoma (DLBCL). Patients with MALT lymphoma were younger (P=0.011) and had lower clinical stage (P=0.014) compared to patients with DLBCL. Cox regression analysis revealed that age, treatment modalities employed, clinical stage, and number of other types of cancer were independent prognostic factors for DLBCL patients.ConclusionPTL demonstrates specific clinical features and is associated with a relatively good prognosis. Older age is associated with poor DSS in both MALT patients and DLBCL patients. Additionally, combination of different treatment modalities is associated with improved DSS in DLBCL patients.

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Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Thyroid

Cited by 5 publications

References 9 publications

Lymphome de hodgkin primitif de la thyroïde: à propos d'un cas

Lymphome de hodgkin primitif de la thyroïde: à propos d'un cas

An 18-year population-based study on the epidemiology, clinical features, treatment, and outcome of nodular lymphocyte predominant Hodgkin lymphoma, single center experience in Oman

Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study

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