Nodular localized primary cutaneous amyloidosis: a bullous variant

LaChance, Avery; Phelps, Amanda; Finch, Justin; Lu, Jun; Elaba, Zendee; Rezuke, William N.; Murphy, Michael J.

doi:10.1111/ced.12305

Cited by 14 publications

(14 citation statements)

References 8 publications

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“…The case in our study presented with a rare bullous-like nodular variant. LaChance et al reported a bullous variant of PLCNA in a 51-year-old man on his third right toe [ 10 ]. PLCNA mainly occurs between the ages of 40 and 60, with the same proportion in men and women [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report

Zhao

2021

Open Life Sciences

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Primary skin amyloidosis is a chronic skin disease in which amyloid deposits in the normal skin tissues without involving other organs. At present, the causes and mechanisms of morbidity have not been fully elucidated. There are few clinical reports of nodular skin amyloidosis, and the domestic reports are mostly limited cases. This study reported a rare case of a 46-year-old woman with primary localized cutaneous nodular amyloidosis (PLCNA). The patient presented with features of lymphatic malformation, a plexiform nodule of small blisters. Histological examination revealed amyloid deposits involving the superficial and deep dermis with a small number of plasma cells. Further examinations did not reveal evidence of systemic involvement, indicating a PLCNA. The presentation as lymphatic malformation lesions illustrates the importance of clinical pathology. Nodular amyloidosis typically manifests as single or multiple yellow-brown nodules or plaques of a few millimeters to several centimeters. The center of the nodule sometimes shows atrophy and relaxation or forms a bullous. It is recommended to perform a pathological examination to confirm the diagnosis to distinguish it from lymphatic malformation.

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Section: Discussionmentioning

confidence: 99%

Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report

Zhao

2021

Open Life Sciences

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“…Our patient presented with a typical solitary firm waxy plaque. Rarer variants include nodular primary amyloidosis with extensive involvement, bullous and genital variants 6–8…”

Section: Discussionmentioning

confidence: 99%

Curious facial plaque diagnosed as nodular primary localised cutaneous amyloidosis

Caruana

McCusker²,

Harper

et al. 2019

BMJ Case Rep

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Nodular primary localised cutaneous amyloidosis (NPLCA) is the rarest form of cutaneous amyloidosis, with a predilection for facial and acral skin. We present a 63-year-old Caucasian with a 10-year history of an asymptomatic plaque on his left cheek, starting 2 years after being scratched by a cat in the same area. A biopsy showed nodules of eosinophilic material in the deep dermis and subcutaneous fat, with plasma cells in the dermis. Congo red staining displayed apple-green birefringence within the eosinophilic material. Immunohistochemistry for serum amyloid P was positive within the eosinophilic material and immunohistochemistry showed lambda light chain restriction within the plasma cells, consistent with NPLCA. The causal relationship of the cat scratch to NPLCA in our patient remains unclear. While trauma-induced amyloidosis has been recognised in papular and macular amyloid, few case reports indicate an association with nodular amyloidosis.

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“…Immunostains reveal cytokeratin positivity, indicating that the material is derived from keratinocytes. 10 PLCNA occurs in the sixthseventh decades of life with no sex predilection. 2,4 The primary localized form of cutaneous nodular amyloidosis, PLCNA, is rare and manifests as waxy yellowish to red-brown plaques, papules, or nodules on the legs, head, trunk, arms, and genitalia.…”

Section: Discussionmentioning

confidence: 99%

Nodular Amyloidosis Derived From Keratinocytes

Cornejo¹,

Lagana

Deng³

2015

The American Journal of Dermatopathology

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Primary, localized cutaneous amyloidosis includes macular, lichen, and nodular (tumefactive) types in which the amyloid deposits are limited to the dermis without systemic involvement. The material in lichen and macular amyloidosis is derived from epidermal keratinocytes [keratinocyte-derived amyloid (AK)], whereas that in nodular amyloidosis is derived from immunoglobulin light-chains amyloid (AL). Primary, localized cutaneous nodular amyloidosis (PLCNA) is a form of primary, localized cutaneous amyloidosis that has been associated with a risk of progression to systemic amyloidosis. We report an unusual case of nodular AK-type amyloid deposited in the dermis of the feet. The patient is a 60-year-old woman with asymptomatic verrucoid-like lesions present around the medial and lateral aspects of the bilateral heels for 1-2 years. A biopsy showed massive deposition of eosinophilic amorphous material in the papillary and reticular dermis. The material stained positive for Congo red with apple-green birefringence on polarized light. It was also positive for pan-cytokeratin and negative for kappa and lambda light-chain immunostains. An extensive workup was negative for systemic involvement. Lipid chromatography tandem mass spectrometry confirmed that the deposition was AK-type amyloid. We believe that this is the first case of PLCNA with AK deposition. This entity should be included in the differential diagnosis of PLCNA so that an extensive systemic workup may be avoided.

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Nodular localized primary cutaneous amyloidosis: a bullous variant

Cited by 14 publications

References 8 publications

Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report

Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report

Curious facial plaque diagnosed as nodular primary localised cutaneous amyloidosis

Nodular Amyloidosis Derived From Keratinocytes

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