Nodular fasciitis of the periorbital soft tissue in an adolescent confirmed by USP6 gene rearrangement

Nodular fasciitis of the orbit: rapid growth phase post iatrogenic incisional trauma

“…The exact aetiology of NF remains unclear. Historically, it was thought to be a reactive proliferative lesion with an association with previous trauma and subsequent inflammation [ 6 ]. However, only 10%–15% of cases in the literature are associated with trauma, as such it is unlikely to be the sole causative factor [ 6 ].…”

“…Historically, it was thought to be a reactive proliferative lesion with an association with previous trauma and subsequent inflammation [ 6 ]. However, only 10%–15% of cases in the literature are associated with trauma, as such it is unlikely to be the sole causative factor [ 6 ]. The recent identification of the recurrent gene rearrangement of ubiquitin-specific protease 6 ( USP6 ) in ~90% of NF cases suggests a clonally proliferative nature [ 7 ].…”

Mid-thoracic Nodular Fasciitis: A Diagnostic Dilemma

“…It may occur anywhere on the body, but most commonly affects the forearm (27-29%) [ 2 ]. While the etiology of NF remains partially understood, it is believed to involve reactive proliferation possibly linked to minor trauma or inflammation [ 3 ]. This rapid and sometimes alarming growth often leads to misdiagnoses as more aggressive or malignant lesions, emphasizing the need for accurate diagnosis to prevent unnecessary patient anxiety and inappropriate interventions.…”