Nodular fasciitis of the breast: the report of three cases

Abstract

Background Nodular Fasciitis is a benign fibroblastic proliferation in soft tissues, which mostly occurs in the upper extremities, trunk, head and neck region. It is rarely reported to occur in the breast. Case presentation Herein, we present sonograms of nodular fasciitis in the breast at different durations in three cases. In Case 1, we provided the longest follow-up time in all literatures. In Case 2 and Case 3, we provided the automated breast ultrasound finding of breast nodular fasciitis for the first time. Conclusion Nodular Fasciitis shows clinical features and ultrasonography findings are similar to those of breast cancer. For superficially located breast lesions with a single and rapid growth, nodular fasciitis may be considered in the differential diagnosis of benign entities resembling malignant tumors on breast imaging.

Breast nodular fasciitis in a postmenopausal woman: A case report and review of recent literature

“…and Cloutier et al. were excluded in the following analysis as disaggregated data was inaccessible and the remaining 11 cases were included in the review [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] . All patients were women and the mean age was 49 years (29-88).…”

Knob, Clot, Protuberance–Nodular Fasciitis

“…Nodular fasciitis is immune reactive to smooth muscle actin (SMA), muscle specific actin (MSA) or calponin [3,4]. Nodular fasciitis is immune non-reactive to desmin, h-caldesmon, S100 protein, SRY-related HMG-box 10(SOX10), CD34, ETS family transcription factor (ERG), epithelial membrane antigen (EMA) or keratin [3,4] (Figure 1 & 2).…”

“…Nodular fasciitis requires segregation from neoplasms such as dermatofibrosarcoma protuberans, desmoid type fibromatosis or fibrous histiocytoma [3,4]. Upon plain radiography or magnetic resonance imaging, demarcation of nodular fasciitis from diverse sarcomas can be challenging [3,4]. Simple surgical extermination mpphe-202208011 of neoplasm is optimal and recommended therapeutic technique.…”

“…Simple surgical extermination mpphe-202208011 of neoplasm is optimal and recommended therapeutic technique. Occasionally, spontaneous tumour regression may occur following cogent tissue sampling [3,4]. Following inadequate surgical eradication, tumour reoccurrence is exceptional [3,4].…”

“…Occasionally, spontaneous tumour regression may occur following cogent tissue sampling [3,4]. Following inadequate surgical eradication, tumour reoccurrence is exceptional [3,4].…”