Nodular Fasciitis of the Breast Previously Misdiagnosed as Breast Carcinoma

Abstract

Background: Nodular fasciitis of the breast is a rare be-nign pathology that can mimic breast cancer clinically, radiologically, and histopathologically. Case Report: An 18-year-old female patient had first visited a physician in a different center with the complaint of a lump in her left breast. Breast examination had revealed a palpable mass located in the left upper outer quadrant. Ultrasonography had demonstrated a hypo-echoic lesion. Excisional biopsy of the lump had been performed and histopathologic examination misdiagnosed this lump as a mesenchymal tumor. The patient was then referred to our clinic for further investigations. Pathologic revision was performed and the diagnosis of nodular fasciitis of the breast was established. Conclusion: Awareness of this rare clinical entity, nodular fasciitis, in the breast eliminates the misdiagnosis of breast cancer.

Nodular fasciitis complicating a staged surgical excision of dermatofibrosarcoma protuberans

“…Several case reports describe nodular fasciitis with clinical presentations, imaging studies, and fine-needle aspiration cytology mimicking malignancy leading to misdiagnosis of breast cancer, sarcoma, and pleomorphic adenoma [7][8][9][10]. Although the pathogenesis eludes current knowledge, proposed mechanisms include response to traumatic injury or other reactive and inflammatory processes [7].…”

Cervical Lymphadenitis Due to Nodular Fasciitis in a Child

“…There is mito c ac va on, with no atypical cells. Immunohistochemical examina on shows that spindle cells express vimen n and ac n, but not desmin, kera n or S-100 proteins 5,7 . Rapid onset, chronic infl amma on in the stroma, and the absence of atypia suggests that the lesion is benign 8 .…”

“…The case has been followed up for the past 30 months and there has been no evidence of recurrence. such as high cellularity, increased mito c ac vity, and infi ltra ve growth pa ern 7 . Ozben et al 7 reported a case of NF of the breast previously misdiagnosed as breast carcinoma.…”

“…such as high cellularity, increased mito c ac vity, and infi ltra ve growth pa ern 7 . Ozben et al 7 reported a case of NF of the breast previously misdiagnosed as breast carcinoma. The key cytological features for diagnosis are plump, immature fi broblas c cells, chronic infl ammatory cells, capillary prolifera on, and vascular channels with extravasated red blood cells in an edematous myxoid background.…”

“…The diagnosis usually requires the histopathological examina on of an excisional biopsy 7 . An accurate histopathological diagnosis prevents an aggressive surgery.…”