Nodular fasciitis, a forgotten entity

Abstract

Awareness of this entity among dermatologists is important as misdiagnosis may lead to unnecessary treatments associated with increased morbidity.

Nodular fasciitis of the face: A case report

“…Immunohistochemistry is useful to obtain an accurate diagnosis. The characteristic profile is positivity for smooth muscle actin, vimentin, and occasionally focally for desmin, whereas S-100, cytokeratin, and CD34 are not expressed [5,18,19].…”

“…Consideration of clinical differential diagnosis includes lipoma, fibromatosis, dermatofibroma, neuroma, neurofibroma, myxoma, benign cyst, benign and malignant fibrous histiocytoma, dermatofibrosarcoma protuberans, fibrosarcoma, leiomyosarcoma, spindle cell carcinoma and melanoma [5,10,17,18].…”

“…Even conservative treatment and clinical follow-up may be a good option as many tumours regress spontaneously. Recurrence of nodular fasciitis has been documented, however, it is so rare that recurrence of a lesion classified as nodular fasciitis should lead to a critically review of the original diagnosis as reappraisal often reveals a malignant disease [3,5,10,19].…”

“…Although rare, nodular fasciitis is the most common pseudosarcoma of soft tissues [2]. However, it is often misdiagnosed as a malignant tumour due to its rapid growth, infiltrative growth pattern, high cellularity, and increased mitotic activity [[3], [4], [5]].…”

USP6-Associated Neoplasms: A Rapidly Expanding Family of Lesions

“…Immunohistochemical analysis is only helpful to exclude other entities, as NF displays variable staining with SMA, focally with desmin and with CD68, usually highlighting the reactive histiocytic component with possible occurrence of multinucleated giant cells. 35 In 2011, rearrangements of USP6 were detected in 44 out of 48 (92%) NF samples. 36 No fusions with CDH11 and COL1A1 as previously reported in ABC were found.…”