Nodular Amyloidosis in the Trachea of a Dog

Dill, G. S.; Stookey, J. L.; Whitney, Glayde

doi:10.1177/030098587200900402

Cited by 14 publications

(8 citation statements)

References 4 publications

(1 reference statement)

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“…Possible differential diagnoses for intraluminal tracheal nodules in dogs included parasites ( Oslerus osleri , Onchocerca species),3–5 primary and metastatic neoplasia (cartilaginous tumours such as osteochondroma, chondroma, chondrosarcoma; mast cell tumour, leiomyoma),6 7 eosinophilic granuloma,8 nodular hyperplastic tracheitis,9 nodular amyloidosis,10 tracheal papillomatosis11 and tracheobronchopathia osteochondroplastica 12…”

Section: Differential Diagnosismentioning

confidence: 99%

Complete resolution of diffuse inflammatory tracheal stenosis in a dog

Costa

Palma

Dennis

et al. 2020

Vet Record Case Reports

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A four-year-old female entire Weimaraner, recently diagnosed with epilepsy, was referred with a three-week history of coughing and lethargy. The dog had been diagnosed with aspiration pneumonia on thoracic radiographs, but the cough continued despite antibiotic therapy and an apparent improvement in the radiographic lung changes. CT of the thorax revealed a diffuse and severe nodular thickening of the tracheal wall. Tracheoscopy showed a thickened and irregular mucosa with multiple nodules causing segmental stenosis of the trachea. Histopathology of the nodular tracheal mucosa demonstrated severe, multifocal to diffuse neutrophilic inflammation. Once infectious and neoplastic causes were excluded, the dog was diagnosed with an inflammatory tracheitis of unknown aetiology. A tapering course of glucocorticoids was prescribed, which led to a complete clinical and endoscopic resolution of the coughing and tracheal lesions, respectively.

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Section: Differential Diagnosismentioning

confidence: 99%

Complete resolution of diffuse inflammatory tracheal stenosis in a dog

Costa

Palma

Dennis

et al. 2020

Vet Record Case Reports

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“…2 In dogs, nodular airway diseases include Oslerus osleri infection, nodular amyloidosis, eosinophilic granulomas, tracheal papillomatosis, and tracheal neoplasia. [12][13][14][15] Nodular epithelial hyperplasia also has been described in association with chronic tracheitis. 16 Treatment of TO in people is not indicated unless nodules are causing airway obstruction, in which case endoscopic removal or laser therapy is often performed.…”

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confidence: 99%

Tracheobronchopathia Osteochondroplastica in a Dog

et al. 2004

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A 9-year-old spayed female West Highland White Terrier was referred to the Washington State University (Pullman, WA) Veterinary Teaching Hospital (WSU-VTH) for evaluation of a suspected tracheal mass. For most of her life, the dog had experienced periodic respiratory difficulty, primarily inspiratory, after exercise. An increased frequency of episodes of respiratory difficulty was reported in the 6 months before examination at the WSU-VTH. Neither coughing nor other clinical signs suggestive of respiratory disease were observed between episodes of respiratory difficulty. Thoracic radiographs obtained by the referring veterinarian approximately 6 months before examination at the WSU-VTH were consistent with focal tracheal thickening.Additional history offered no clues to the origin of the dog's respiratory signs. The dog had been obtained as a puppy from Missouri and had traveled to Wisconsin between 6 and 7 years before examination at the WSU-VTH, but she had no other travel history since that time. Prior treatments included amoxicillin for suspected lower urinary tract infection 3 months before referral, diethylstilbesterol (dose not specified) for urinary incontinence, and methionine for urine acidification. None of these treatments changed the character of the respiratory signs.On physical examination, the dog was overweight. Temperature, pulse rate, and respiratory rate were normal, as was the dog's respiratory pattern. A cough could not be induced with tracheal palpation, and breath sounds were normal. The rest of the physical examination, except for a missing upper left 1st incisor tooth, was normal.The only abnormal result on CBC and biochemistry was mild neutrophilia (10,248/ L; reference range, 3,000-7,100/ L); a urine sample could not be obtained. On thoracic radiographs, narrowing of the trachea on the lateral view and possibly a mass in the ventral trachea at the 1st rib were observed (Fig 1). During bronchoscopy, tracheal collapse and numerous white-to-yellowish nodules were noted on the ventral and lateral walls of the trachea, typically associated with tracheal rings (Fig 2), and in the lobar bronchi. A discrete mass was not seen. The nodules were hard, did not move with pressure from the tip of the endoscope or a biopsy forceps, and appeared to be covered with mucosa. Most nodules were less than 3 mm in diameter, as gauged from the diameter of the biopsy forceps.

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“…Staining with congo red and examination by polarized light of sections from representative blocks taken from the trachea and bronchi of this case was also negative for amyloid. Furthermore, nodular amyloidosis of the trachea of the dog has been recorded only once to our knowledge (Dill et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…Osteosarcoma, osteoma, chondroma, osteochondroma and carcinoma have been reported as tracheal tumours (Moulton, 1961 ;Maksic & Small, 1965;Reed, 1965;Brodey et al, 1969;Gourley, Morgan & Gould, 1970;Ettinger & Ticer, 1975). Hyperplastic tracheal proliferations produced iatrogenically or by traumata (Knecht, Schall & Barret, 1972;Gordon, 1973;Ettinger & Ticer, 1975), Filaroides osleri infestation (Soulsby, 1965;Smith, Jones & Hunt, 1972;Kelly, 1964), nodular amyloidosis (Dill, Stookey & Witney, 1972) and unknown causes (Costa, 1947;Kelly, 1964) have been reported. This paper records a tracheal obstruction caused by multiple nodular proliferations of the mucosa.…”

Section: Introductionmentioning

confidence: 99%