Nodular amelanotic melanoma

Abstract

FIgure 1: Tumoral lesion approximately 4cm in diameter, located on the lower back, with surrounding erythema FIgure 2: Histopathology: Confluence of nests of large, atypical melanocytes. The cells are irregular in size, shape, and spacing. Many have hyperchromatic and pleomorphic nuclei and pigmented cytoplasm

An angiomatous nodule of the cheek: What is your diagnosis?

“…(2) The difficulty of diagnosis lies in the lack of pigment, therefore clinical criteria like the ABCDE algorithm cannot be applied in this case [1,2]. The most common form is the nodular variant, but any other clinicopathological form can be found [3]. Clinical presentation varies from erythematous patch or plaque to angiomatous nodule or tumor in more advanced cases [1][2][3].…”

“…The most common form is the nodular variant, but any other clinicopathological form can be found [3]. Clinical presentation varies from erythematous patch or plaque to angiomatous nodule or tumor in more advanced cases [1][2][3]. Although structures that suggest the presence of melanin are absent, dermoscopy has been a valuable tool in suspecting the diagnosis of AM [4].…”

Cells to Surgery Quiz: October 2020

“…Amelanotic melanoma: Amelanotic melanoma refers to melanoma with little or no pigmentation, a form constituting between 1.8% and 8.1% of all melanomas (Neto et al, 2016). Whereas most melanomas appear pigmented, amelanotic melanoma may present as a poorly defined erythematous macule, papule, nodule, or plaque, and the nodular form is most common (Neto et al, 2016;Silva et al, 2019).…”

Skin Cancer Back to Basics

“…Diagnosis of AM is established through histopathology, which shows nests of large, irregularly shaped and spaced melanocytes, hyperchromatic and pleomorphic nuclei, and pigmented cytoplasms (Silva et al, 2019). Melanoma is known for its diverse histopathological presentation, mimicking Ewing sarcoma, rhabdomyosarcoma, chondrosarcoma, or small cell carcinoma (Shetty et al, 2014).…”

“…Prognosis relies on pathologic staging assessed through Breslow tumor thickness, nodal status, and metastasis (Silva et al, 2019). Because of nonspecific clinical appearance that impedes timely diagnosis, AM is typically diagnosed at a late stage, so prognosis is usually worse when compared with pigmented melanoma (Stojkovic-Filipovic & Kittler, 2014).…”