Nodal involvement and survival in synovial, clear cell, angio, rhabdo, and epithelioid sarcoma.

Wang, Haotong; Miao, Ruoyu; Jacobson, A.; Boyd, Graham; Goldberg, Saveli; Mitra, Deverati; Coté, Gregory M.; Choy, Edwin; Hornicek, Francis J.; Raskin, Kevin A.; DeLaney, Thomas F.; Chen, Yen‐Lin

doi:10.1200/jco.2018.36.15_suppl.11567

Cited by 4 publications

(3 citation statements)

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“…Age was evaluated both as a continuous variable and categorical variable (< 18 and ≥ 18). The histologies of clear cell, angiosarcoma, rhabdomyosarcoma, and epithelioid (CARE) were grouped as “CARE” histologies, given their higher propensity for LNM as previously described [4, 13] Other categories for histology included synovial sarcoma, given conflicting reports regarding its association with LNM [14-16], and “other.” Univariate comparisons between the LNM cohort and node-negative cohort were made via the Chi-square test. Univariate and logistic regression models were performed to evaluate variables associated with pathologic node positivity.…”

Section: Methodsmentioning

confidence: 99%

Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database

Miccio

Jairam

Gao

et al. 2019

Cureus

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Background and ObjectivesLymph node metastases (LNM) in soft tissue sarcoma (STS) of the trunk and extremity are rare but are associated with worse survival. Established risk factors for LNM in this group are based on small institutional retrospective reviews. This study identifies the risk factors associated with LNM in otherwise non-metastatic trunk/extremity STS patients using the National Cancer Database (NCDB) and sought out to delineate a high-risk group that may be considered for pathologic nodal evaluation.MethodsThe files of 10,731 patients with STS of the trunk/extremity without distant metastasis from 2004 - 2015 were evaluated. Exclusion criteria included neoadjuvant therapy and a lack of pathologic nodal evaluation. Univariate and multivariable logistic regression models were performed to evaluate variables associated with LNM.ResultsOf the total of 10,731 patients, 223 (2.1%) had LNM. On multivariable analysis, LNM was associated with Grade 3 tumors (odds ratio (OR) 15.6, 95% confidence interval (CI) 6.36 - 38.04, p < 0.001) and clear cell/angiosarcoma/rhabdomyosarcoma/epithelioid (CARE) histology (OR 4.72, 95% CI 3.35 - 6.66, p < 0.001), lymphovascular invasion (LVI) (OR 5.86, 95% CI 3.33 - 10.31, p < 0.001, and bone invasion (BI) (OR 2.73, 95% CI 1.32 - 5.61, p = 0.006). Patients with Grade 3 CARE tumors (n = 402) had an 11.9% risk of LNM vs. 1.7% of adults without all these characteristics (p < 0.001). Patients with Grade 3 CARE tumors and either LVI or BI (n = 36) had a 33.3% risk of LNM.ConclusionsHigh-grade and CARE histology are associated with LNM in STS. Adult patients with both features have an overall 11.9% risk of LNM and may be considered for pathologic LN assessment, particularly with the presence of LVI or BI.

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Section: Methodsmentioning

confidence: 99%

Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database

Miccio

Jairam

Gao

et al. 2019

Cureus

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“…More recent data have reported that the risk of lymph node metastasis of synovial sarcoma is approximately 3% to 7%, lower than previously considered. [1,[22][23][24] Keung et al [1] reported that the intrathoracic synovial sarcomas showed the highest rate of lymph node metastases (6.6%) among the various anatomic sites, including the trunk/extremity (2.5%), head/neck/face (5.6%), and intraabdominal/visceral (4.1%) location.…”

Section: Discussionmentioning

confidence: 99%

Biphasic synovial sarcoma with a striking morphological divergence from the main mass to lymph node metastasis

Woo

2022

Medicine

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Rationale: Synovial sarcoma accounts for 5% to 10% of all soft tissue sarcomas and involves almost any anatomic site, particularly the deep soft tissue of the extremities of young adults. The incidence rate of lymph node metastases in synovial sarcoma is 3% to 7%, but the detailed morphological features of the metastatic tumors in the lymph node have not been documented. Patient concerns: A 64-year-old Korean man presented with a huge mass in the left lower thorax and multiple hypermetabolic lymph nodes along the mediastinal, supraclavicular, internal mammary, and retrocrural regions. Diagnoses: The patient was diagnosed with primary pleuropulmonary biphasic synovial sarcoma with lymph node metastases, where the main mass mostly comprised spindle cells (>95%) and the metastatic lymph nodes comprised only epithelial cells. Interventions: Left lower lobe lobectomy with the resection of the chest wall (including left ribs 8-10) and diaphragm and mediastinal lymph node dissection were performed. Outcomes: In the 2-month follow-up period, there have been no complications so far, and the attending physician is currently planning for the adjuvant chemotherapy. Lessons: The main mass and the metastatic lesion can be clearly different morphologically. In tumors with biphasic differentiation, such as synovial sarcoma, cells that constitute only a small fraction of the main mass may appear as the dominant cells in metastatic lesions.

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“…In this series, only two cases, a rhabdo myosarcoma and an angiosarcoma (3%), had nodal disease at presentation. Sarcoma subtypes with a known propensity for lymph node spread include rhabdomyosarcoma, angiosarcoma, epithelioid, clear-cell and synovial sarcoma (2,21).…”

Section: Discussionmentioning

confidence: 99%

Imaging Soft-tissue Sarcomas of the Head and Neck: A Tertiary Soft-tissue Sarcoma Unit Experience

et al. 2019

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Background/Aim: To describe imaging features of head and neck soft-tissue sarcomas. Patients and Methods: Patients with a diagnosis of head and neck sarcoma between 2011 and 2015 were reviewed. Results: There were a total of 62 patients (24 female; median age=60 years). Most common sarcomas were angiosarcoma, undifferentiated pleomorphic sarcoma and sarcoma not otherwise specified. They were most commonly located in cranial and neck superficial soft tissues. Average tumour size

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Nodal involvement and survival in synovial, clear cell, angio, rhabdo, and epithelioid sarcoma.

Cited by 4 publications

References 0 publications

Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database

Predictors of Lymph Node Involvement by Soft Tissue Sarcoma of the Trunk and Extremity: An Analysis of the National Cancer Database

Biphasic synovial sarcoma with a striking morphological divergence from the main mass to lymph node metastasis

Imaging Soft-tissue Sarcomas of the Head and Neck: A Tertiary Soft-tissue Sarcoma Unit Experience

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