Nodal CT density and total tumor volume as prognostic factors after radiation therapy of stage III/IV head and neck cancer

Grabenbauer, Gerhard G.; Steininger, H; Meyer, Martin; Fietkau, Rainer; Brunner, Thomas; Heinkelmann, Pia; Hornung, Joachim; Iro, H; Spitzer, W.J.; Distel, Luitpold; Kirchner, Thomas; Sauer, Rolf

doi:10.1016/s0167-8140(98)00016-4

Cited by 80 publications

(56 citation statements)

References 40 publications

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“…Evidence has shown that Ki-67 may be a potential marker for radiosensitivity in head and neck carcinomas when using a cutoff point at o20 or X20% (Raybaud-Diogene et al, 1997;Grabenbauer et al, 1998;Couture et al, 2002). Koelbl et al (2001), however, did not find a correlation between Ki-67 expression and radiation response, but an improved local control in tumours with complete response after radiotherapy (40 Gy).…”

Section: Discussionmentioning

confidence: 93%

“…Several studies have provided evidence that with a higher proliferative activity, head and neck cancers may respond significantly better to radiotherapy (Raybaud-Diogene et al, 1997;Grabenbauer et al, 1998;Kropveld et al, 1998;Couture et al, 2002). Evidence has shown that Ki-67 may be a potential marker for radiosensitivity in head and neck carcinomas when using a cutoff point at o20 or X20% (Raybaud-Diogene et al, 1997;Grabenbauer et al, 1998;Couture et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

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Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

et al. 2008

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Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer associated with poor prognosis. Methods for determining the aggressiveness of OTSCC from analysis of the primary tumour specimen are thus highly desirable. We investigated whether genomic instability and proliferative activity (by means of Ki-67 activity) could be of clinical use for prediction of locoregional recurrence in 76 pretreatment OTSCC paraffin samples (stage I, n ¼ 22; stage II, n ¼ 33; stage III, n ¼ 8; stage IV, n ¼ 13). Eleven surgical tumour specimens were also analysed for remnants of proliferative activity after preoperative radiotherapy. Ninety-seven percent of cases (n ¼ 72) were characterised as being aneuploid as measured by means of image cytometry. Preoperative radiotherapy (50 -68 Gy) resulted in significant reduction of proliferative activity in all patients for which post-treatment biopsies were available (P-value ¼ 0.001). Proliferative activity was not associated with response to radiation in stage II patients. However, we report a significant correlation between high proliferation rates and locoregional recurrences in stage I OTSCC patients (P-value ¼ 0.028). High-proliferative activity is thus related to an elevated risk of recurrence after surgery alone. We therefore conclude that Ki-67 expression level is a potentially useful clinical marker for predicting recurrence in surgically treated stage I OTSCC.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

et al. 2008

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“…In recent studies, MNV and primary tumor volume were reported to play important roles in predicting prognosis [8,9,20,21]. In an analysis of 79 HNSCC patients who underwent primary irradiation or chemoradiation, MNV was the most important prognostic factor for the control of pathological nodes in the neck [20].…”

Section: Discussionmentioning

confidence: 99%

“…Measurement of tumor volume using pretreatment computed tomography (CT) images has been proposed as a method for predicting prognosis in different malignancies [5,6]. As lymph node metastasis status has a great impact on the prognosis of HNSCC patients [7], recent studies have suggested regional lymph node volume, and not only the primary tumor volume, as a predictor of treatment outcome [8,9]. …”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Metastatic Nodal Volume and Lymph Node Ratio in Patients with Cervical Lymph Node Metastases from an Unknown Primary Tumor

Park

Jung²,

Roh³

et al. 2014

Oncology

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Objective: The presence of metastatic cervical lymph nodes (MCNs) is an unfavorable prognostic factor in head and neck cancer. The total volume of MCNs (MNV) and the lymph node ratio (LNR) may be superior to conventional nodal staging in cervical metastasis from an unknown primary tumor (CUP). We evaluated the prognostic value of MNV and LNR in CUP patients. Methods: Thirty-nine patients with CUP who underwent surgery plus postoperative radiotherapy were reviewed. MNV was measured by preoperative computed tomography and LNR was determined using neck dissection samples. The association of clinicopathologic factors, MNV, and LNR with disease-free survival (DFS) and overall survival (OS) was analyzed. Results: Five-year DFS and OS were 68.4 and 70.8%, respectively, for a median follow-up of 49 months. In multivariate analysis, MNV (>30 ml) was an independent prognostic factor for both DFS and OS (p = 0.004 and p < 0.001, respectively). LNR (>0.14) was identified as an independent predictive factor for DFS (p = 0.041). Conclusion: MNV and LNR are independent prognostic factors in patients with CUP and could facilitate the identification of high-risk patients requiring intensive treatment and surveillance.

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“…Various studies with long term tumour control and survival as end points have identified such cut-off values for PTV ranging from 19.6 cm 3 to 35 cm 3 and for TTV, from 22.8 cm 3 to 110 cm 3 depending upon the places where these were conducted. [13][14][15][16][17][18][19][20][21][22][23] In our study, for early response evaluation at 3 months of CCRT "optimal threshold cut-off" for PTV and TTV were higher (41 cm 3 and 42 cm 3 , respectively), primarily owing to a large tumour burden in our country. This method may categorise patients into either a favourable group (TV less than cut-off) or unfavourable group (TV more than cut-off) at a pre-treatment stage.…”

Section: Discussionmentioning

confidence: 65%

Tumour volumes: Predictors of early treatment response in locally advanced head and neck cancers treated with definitive chemoradiation

Ahlawat

Rawat

Kakria

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Nodal CT density and total tumor volume as prognostic factors after radiation therapy of stage III/IV head and neck cancer

Cited by 80 publications

References 40 publications

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

Prognostic Value of Metastatic Nodal Volume and Lymph Node Ratio in Patients with Cervical Lymph Node Metastases from an Unknown Primary Tumor

Tumour volumes: Predictors of early treatment response in locally advanced head and neck cancers treated with definitive chemoradiation

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