Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Yamamoto, Masamichi; Saijoh, Yukio; Perea-Gómez, Aitana; Shawlot, William; Behringer, Richard R.; Ang, Siew‐Lan; Hamada, Hiroshi; Meno, Chikara

doi:10.1038/nature02418

Cited by 267 publications

(256 citation statements)

References 30 publications

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“…These studies further serve to highlight the idea that the appropriate balance of NO-derivative cell fates (endoderm, mesoderm, and mesendoderm) must be achieved. Balanced Nodal signaling must be achieved in such a manner that the "anterior" ectoderm already in placeboth presumptive neurectoderm and cephalic surface ectoderm-is protected (by Nodal antagonists such as Cerberus and Lefty) from a signaling cascade that converts ectoderm into endoderm and mesoderm (Piccolo et al, 1999;Niehrs, 1999;Thisse et al, 2000;Perea-Gomez et al, 2002;Yamamoto et al, 2004;Kuroda et al, 2004). Protection of the anterior ectoderm appears to be one function of the NO-derived AME (Glinka et al, 1997(Glinka et al, , 1998Shimamiura and Rubenstein, 1997;Bachillier et al, 2000;de Souza and Niehrs, 2000;Kazanskaya et al, 2000;Kiecker and Niehrs, 2001;Mukhopadhyay et al, 2001;Anderson et al, 2002;del Barco Barrantes et al, 2003).…”

Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

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Classic neontology (comparative embryology and anatomy), through the application of the concept of homology, has demonstrated that the development of the gnathostome (jawed vertebrate) skull is characterized both by a fidelity to the gnathostome bauplan and the exquisite elaboration of final structural design. Just as homology is an old concept amended for modern purposes, so are many of the questions regarding the development of the skull. With due deference to Geoffroy-St. Hilaire, Cuvier, Owen, Lankester et al., we are still asking: How are bauplan fidelity and elaboration of design maintained, coordinated, and modified to generate the amazing diversity seen in cranial morphologies? What establishes and maintains pattern in the skull? Are there universal developmental mechanisms underlying gnathostome autapomorphic structural traits? Can we detect and identify the etiologies of heterotopic (change in the topology of a developmental event), heterochronic (change in the timing of a developmental event), and heterofacient (change in the active capacetence, or the elaboration of capacity, of a developmental event) changes in craniofacial development within and between taxa? To address whether jaws are all made in a like manner (and if not, then how not), one needs a starting point for the sake of comparison. To this end, we present here a "hinge and caps" model that places the articulation, and subsequently the polarity and modularity, of the upper and lower jaws in the context of cranial neural crest competence to respond to positionally located epithelial signals. This model expands on an evolving model of polarity within the mandibular arch and seeks to explain a developmental patterning system that apparently keeps gnathostome jaws in functional registration yet tractable to potential changes in functional demands over time. It relies upon a system for the establishment of positional information where pattern and placement of the "hinge" is driven by factors common to the junction of the maxillary and mandibular branches of the first arch and of the "caps" by the signals emanating from the distal-most first arch midline and the lamboidal junction (where the maxillary branch meets the frontonasal processes). In this particular model, the functional registration of jaws is achieved by the integration of "hinge" and "caps" signaling, with the "caps" sharing at some critical level a developmental history that potentiates their own coordination. We examine the evidential foundation for this model in mice, examine the robustness with which it can be applied to other taxa, and examine potential proximate sources of the signaling centers. Lastly, as developmental biologists have long held that the anterior-most mesendoderm (anterior archenteron roof or prechordal plate) is in some way integral to the normal formation of the head, including the cranial skeletal midlines, we review evidence that the seminal patterning influences on the early anterior ectoderm extend well beyond the neural plate and are just as importan...

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Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

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“…Green fluorescent protein reporter gene constructs coupled to hypoblast-specific marker genes, such as Hex (Rodriguez et al 2001) or Cerberus like (Cer1; Mesnard et al 2004), enabled investigations confirming the direction of these movements in the mouse and made experimental analyses possible. These studies demonstrated the dependence of these movements on attracting and repelling effects of TGF-b growth factors, such as nodal and Gdf3, and their Blastocyst elongation and differentiation co-receptor cripto or inhibitor lefty also in the mouse (Yamamoto et al 2004, Chen et al 2006.…”

Section: Cell Migration and The Emerging Body Axes In The Embryonic Discmentioning

confidence: 99%

Blastocyst elongation, trophoblastic differentiation, and embryonic pattern formation

Blomberg¹,

Hashizume²,

Viebahn³

2008

Reproduction

105

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The molecular basis of ungulate and non-rodent conceptus elongation and gastrulation remains poorly understood; however, use of stateof-the-art genomic technologies is beginning to elucidate the mechanisms regulating these complicated processes. For instance, transcriptome analysis of elongating porcine concepti indicates that protein synthesis and trafficking, cell growth and proliferation, and cellular morphology are major regulated processes. Furthermore, potential autocrine roles of estrogen and interleukin-1-b in regulating porcine conceptus growth and remodeling and metabolism have become evident. The importance of estrogen in pig is emphasized by the altered expression of essential steroidogenic and trophoblast factors in lagging ovoid concepti. In ruminants, the characteristic mononucleate trophoblast cells differentiate into a second lineage important for implantation, the binucleate trophoblast, and transcriptome profiling of bovine concepti has revealed a gene cluster associated with rapid trophoblast proliferation and differentiation. Gene cluster analysis has also provided evidence of correlated spatiotemporal expression and emphasized the significance of the bovine trophoblast cell lineage and the regulatory mechanism of trophoblast function. As a part of the gastrulation process in the mammalian conceptus, specification of the germ layers and hence definitive body axes occur in advance of primitive streak formation. Processing of the transforming growth factor-b-signaling molecules nodal and BMP4 by specific proteases is emerging as a decisive step in the initial patterning of the pre-gastrulation embryo. The topography of expression of these and other secreted molecules with reference to embryonic and extraembryonic tissues determines their local interaction potential. Their ensuing signaling leads to the specification of axial epiblast and hypoblast compartments through cellular migration and differentiation and, in particular, the specification of the early germ layer tissues in the epiblast via gene expression characteristic of endoderm and mesoderm precursor cells.

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“…Although gastrulation is normal after targeted inactivation of expression of either of the nodal antagonists, Cerberus-like gene or Lefty1, Cerberus 2/2 ; Lefty1 2/2 double-mutant mice have severe developmental impairment of the anterior embryo (Perea-Gomez et al 2002;Yamamoto et al 2004). In Xenopus laevis, the asymmetry of nodal signaling is partially regulated by two microRNAs (miRNAs), miR-15 and miR-16.…”

Section: Neural Inductionmentioning

confidence: 99%

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Meyers

Kessler

2017

Cold Spring Harb Perspect Biol

119

107

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Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Cited by 267 publications

References 30 publications

21^st Century neontology and the comparative development of the vertebrate skull

21^st Century neontology and the comparative development of the vertebrate skull

Blastocyst elongation, trophoblastic differentiation, and embryonic pattern formation

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

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Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Cited by 267 publications

References 30 publications

21st Century neontology and the comparative development of the vertebrate skull

21st Century neontology and the comparative development of the vertebrate skull

Blastocyst elongation, trophoblastic differentiation, and embryonic pattern formation

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Contact Info

Product

Resources

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21^st Century neontology and the comparative development of the vertebrate skull

21^st Century neontology and the comparative development of the vertebrate skull