Nodal and Extranodal Plasmacytomas Expressing Immunoglobulin A

Shao, Haipeng; Xi, Liqiang; Raffeld, Mark; Pittaluga, Stefania; Dunleavy, Kieron; Wilson, Wyndham H.; Spector, Nelson; Milito, Cristiane; Morais, José Carlos; Jaffe, Elaine S.

doi:10.1097/pas.0b013e3181f17d0d

Cited by 23 publications

(16 citation statements)

References 43 publications

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“…Biopsy of a cervical lymph node showed sheets of IgA kappa positive plasma cells in the interfollicular regions (Figure 6G–I). A group of similar cases of IgA plasmacytomas have been recently described [64]. This report suggests that extramedullary IgA plasmacytomas may be a distinct form of plasma cell neoplasm characterized by younger age at presentation, frequent lymph node involvement, and low risk of progression to myeloma.…”

Section: Sessionmentioning

confidence: 67%

Early lesions in lymphoid neoplasia

et al. 2012

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The increasing use of immunophenotypic and molecular techniques on lymphoid tissue samples without obvious involvement by malignant lymphoma has resulted in the increased detection of “early” lymphoid proliferations, which show some, but not all the criteria necessary for a diagnosis of malignant lymphoma. In most instances, these are incidental findings in asymptomatic individuals, and their biological behaviour is uncertain. In order to better characterize these premalignant conditions and to establish diagnostic criteria, a joint workshop of the European Association for Haematopathology and the Society of Hematopathology was held in Uppsala, Sweden, in September 2010. The panel reviewed and discussed more than 130 submitted cases and reached consensus diagnoses. Cases representing the nodal equivalent of monoclonal B-cell lymphocytosis (MBL) were discussed, as well as the “in situ” counterparts of follicular lymphoma (FL) and mantle cell lymphoma (MCL), topics that also stimulated discussions concerning the best terminology for these lesions. The workshop also addressed the borderland between reactive hyperplasia, and clonal proliferations such as pediatric marginal zone lymphoma and pediatric FL, which may have very limited capacity for progression. Virus-driven lymphoproliferations in the grey zone between reactive lesions and manifest malignant lymphoma were covered. Finally, early manifestations of T-cell lymphoma, both nodal and extranodal, and their mimics were addressed. This workshop report summarizes the most important conclusions concerning diagnostic features, as well as proposals for terminology and classification of early lymphoproliferations and tries to give some practical guidelines for diagnosis and reporting.

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Section: Sessionmentioning

confidence: 67%

Early lesions in lymphoid neoplasia

et al. 2012

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“…Immunohistochemical stains were performed using an automated immunostainer (Ventana Medical Systems, Inc, Tucson, AZ) as described previously. 10 In brief, antigen retrieval was performed using a Tender Cooker (Nordicware, Minneapolis, MN) with citrate buffer. The immunohistochemical panel included CD20, CD3, CD10, BCL2 (clone 124), BCL6, MUM1, IgD, CD21, CD23, MIB1(Ki-67), and PD-1(CD279).…”

Section: Methodsmentioning

confidence: 99%

Follicular Lymphomas in Children and Young Adults

Liu

Salaverría

Pittaluga

et al. 2013

American Journal of Surgical Pathology

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Follicular lymphoma (FL), a common lymphoma in adults, occurs rarely in pediatric and young adult patients. Most pediatric cases have been described as Grade 3, but the criteria to distinguish the pediatric variant of FL (PFL) from usual FL (UFL) in adults are not well defined. We undertook a study of FL in patients under age 30. We identified 63 cases, which were analyzed by morphology, immunohistochemistry, and PCR analysis of IGH@ and IGK@ clonality. These data were correlated with clinical findings including stage, treatment, and outcome. Among the 63 cases, 34 cases were classified as PFL; 22 presenting in lymph nodes, 8 in Waldeyer’s ring and 4 in testis. Clonal immunoglobulin gene rearrangement was detected in 97% of PFL cases, but FISH analysis showed an absence of the BCL2/IGH@ translocation in all cases tested. Twenty-nine cases were classified as UFL, 28 of which presented in lymph nodes. The nodal PFL cases were observed exclusively in males in both children and young adults with a median age of 15 years. They showed marked head/neck predilection, blastoid cytological features with a high proliferation rate, lack of BCL2 protein and t(14;18), low clinical stage at presentation, and good prognosis. PFL involving Waldeyer’s ring were distinguished by MUM1 expression, 50% (3/6) of which carried IRF4 breaks. BCL2 expression was common (63%) in the absence of BCL2/IGH@ translocation. UFL cases were more common in females, exclusively in young adult patients (median age, 24 years) with no patients under age 18. 25/29 were grade 1–2, and four cases were classified as grade 3A. They exhibited a higher clinical stage at presentation. 83% expressed BCL2. Our results indicate that histological and immunophenotypic criteria can reliably separate PFL and UFL, and that UFL is exceptionally rare in the pediatric age group. PFL associated with particular anatomic sites have distinctive features, and should be evaluated separately in future clinical and biological studies.

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“…All biopsies were preserved as formalin-fixed paraffin embedded (FFPE) tissue specimens. Immunohistochemical studies were performed on FFPE tissue sections using a panel of monoclonal antibodies (CD30, CD15, PAX5, CD20, CD3, CD4, and CD8) according to previously published techniques (5, 19). Histopathologic diagnosis was rendered by the authors according to the 2008 World Health Organization (WHO) classification (22).…”

Section: Methodsmentioning

confidence: 99%