NOD2 reduces the chemoresistance of melanoma by inhibiting the TYMS/PLK1 signaling axis
Fang Yun,
Na Wu,
Xiaojia Yi
et al.
Abstract:Nucleotide-binding oligomerization domain 2 (NOD2) is an immune sensor crucial for eliciting the innate immune responses. Nevertheless, discrepancies exist regarding the effect of NOD2 on different types of cancer. This study aimed to investigate these function of NOD2 in melanoma and its underlying mechanisms. We have validated the tumor suppressor effect of NOD2 in melanoma. NOD2 inhibited the proliferation of melanoma cells, hindering their migration and invasion while promoting the onset of apoptosis. Our … Show more
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