NOD2 induces autophagy to control AIEC bacteria infectiveness in intestinal epithelial cells

Negroni, Anna; Colantoni, Eleonora; Vitali, Roberta; Palone, Francesca; Pierdomenico, Maria; Costanzo, Manuela; Cesi, Vincenzo; Cucchiara, Salvatore; Stronati, Laura

doi:10.1007/s00011-016-0964-8

Cited by 39 publications

(28 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 13 In humans and experimental animals, it has emerged that genetic defects in bacterial sensing and killing (eg, NOD2, ATG16L ) are frequently associated with IBD. 15 – 17 Variants in these genes are associated with downstream effects on protein function and, subsequently, clinical disease. 15 – 17 Recent studies in Boxer dogs and French Bulldogs with GC have identified a region in chromosome 38 encoding genes in the signaling lymphocyte activation molecule family that are involved in the sensing and killing of E coli in murine models.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat

Leal

Simpson

Fine³

et al. 2017

Journal of Feline Medicine and Surgery Open Reports

View full text Add to dashboard Cite

Case summaryThis report describes a 4-year-old cat with chronic intermittent haematochezia and faecal incontinence of 7 months’ duration. Investigation revealed severe colonic multifocal mucosal ulcerations and infiltration of the mucosal lamina propria by large numbers of periodic acid–Schiff-positive macrophages. Fluorescence in situ hybridisation analysis of colonic biopsies revealed multifocal clusters of intracellular Escherichia coli. Treatment with fluoroquinolones for 6 weeks led to a complete resolution of clinical signs.Relevance and novel informationThe findings reveal that mucosally invasive E coli can also be associated with granulomatous colitis in cats and indicate the need for diagnostic testing of mucosal samples for E coli and other infectious agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat

Leal

Simpson

Fine³

et al. 2017

Journal of Feline Medicine and Surgery Open Reports

View full text Add to dashboard Cite

show abstract

“…In particular, recent studies have identified that NOD2-mediated induction of autophagy in intestinal epithelial cells was necessary to hold bacterial burden, thereby limiting inflammation [23]. NOD2 was identified as one of the inflammatory bowel disease susceptibility genes involved in autophagy [24,25].…”

Section: Crosstalk Between Autophagy and The Inflammasome Machineriesmentioning

confidence: 99%

Checks and Balances between Autophagy and Inflammasomes during Infection

Seveau

Turner

Gavrilin

et al. 2018

Journal of Molecular Biology

View full text Add to dashboard Cite

Autophagy and inflammasome complex assembly are physiological processes that control homeostasis, inflammation, and immunity. Autophagy is a ubiquitous pathway that degrades cytosolic macromolecules or organelles, as well as intracellular pathogens. Inflammasomes are multi-protein complexes that assemble in the cytosol of cells upon detection of pathogen- or danger-associated molecular patterns. A critical outcome of inflammasome assembly is the activation of the serine protease caspase-1, which activates the pro-inflammatory cytokine precursors pro-IL-1β and pro-IL-18. Studies on chronic inflammatory diseases, heart diseases, Alzheimer's disease, and multiple sclerosis revealed that autophagy and inflammasomes intersect and regulate each other. In the context of infectious diseases, however, less is known about the interplay between autophagy and inflammasome assembly, although it is becoming evident that pathogens have evolved multiple strategies to inhibit and/or subvert these pathways and to take advantage of their intricate crosstalk. An improved appreciation of these pathways and their subversion by diverse pathogens is expected to help in the design of anti-infective therapeutic interventions.

show abstract

“…36,37 A number of genes in IBD susceptibility loci restrict intracellular bacteria, including ATG16L1, NOD2, IRGM, CALCOCO2/NDP52, and GPR65, suggesting that antibacterial autophagy is a major pathway underlying intestinal homeostasis in vivo. 5,31,[38][39][40][41] These genes function in various steps of the antibacterial autophagy cascade, including bacterial sensing (NOD2), bacterial targeting (IRGM, CALCOCO2), autophagosome elongation (ATG16L1), and lysosomal function (GPR65). The interaction between NOD2 and ATG16L1 in antibacterial autophagy has been of particular interest and this interaction is thought to be important for bacterial clearance and increased cytokine release.…”

Section: Autophagy and The Control Of Intestinal Microbesmentioning

confidence: 99%

Mechanisms and function of autophagy in intestinal disease

Lassen

Xavier

2018

Autophagy

View full text Add to dashboard Cite

The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in intestinal homeostasis. These genetic studies have identified a critical role for macroautophagy/autophagy and more recently, lysosomal function, in maintaining the intestinal barrier and mucosal homeostasis. This review highlights recent work on the functional characterization of IBD-associated human genetic variants in cell type-specific functions for autophagy.

show abstract

NOD2 induces autophagy to control AIEC bacteria infectiveness in intestinal epithelial cells

Abstract: The NOD2-mediated autophagy induction is crucial to hold the intramucosal bacterial burden, especially towards AIEC, and to limit the resulting inflammatory response. Autophagy is active in inflamed colonic tissues of IBD pediatric patients.

Cited by 39 publications

References 44 publications

Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat

Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat

Checks and Balances between Autophagy and Inflammasomes during Infection

Mechanisms and function of autophagy in intestinal disease

Contact Info

Product

Resources

About