NOD2-associated diseases: Bridging innate immunity and autoinflammation

Borzutzky, Arturo; Fried, Ari J.; Chou, Janet; Bonilla, Francisco A.; Kim, Susan; Dedeoğlu, Fatma

doi:10.1016/j.clim.2009.05.005

Cited by 80 publications

(64 citation statements)

References 74 publications

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“…At least 58 disease-associated mutations in nod2 gene (CARD15) have been reported [85]. Approximately 80% of these are associated with Crohn's disease (CD), while the remaining 20% have been linked with Blau syndrome (BS) and early onset sarcoidosis (EOS).…”

Section: Nod2 and Crohn Diseasementioning

confidence: 99%

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The protein Nod2: An innate receptor more complex than previously assumed

Lecat

Piette

Legrand-Poels

2010

Biochemical Pharmacology

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Please check your proof carefully and mark all corrections at the appropriate place in the proof (e.g., by using on-screen annotation in the PDF file) or compile them in a separate list.For correction or revision of any artwork, please consult http://www.elsevier.com/artworkinstructions.Any queries or remarks that have arisen during the processing of your manuscript are listed below and highlighted by flags in the proof. Click on the 'Q' link to go to the location in the proof. Location inQuery / Remark: click on the Q link to go article Please insert your reply or correction at the corresponding line in the proof Q1If there are fewer than seven authors, please supply all their names; if there are seven or more authors, please supply the first six authors' names, followed by 'et al.'Thank you for your assistance. Graphical AbstractBiochemical Pharmacology xxx (2010) xxx-xxx pp: xxx-xxx The protein Nod2: An innate receptor more complex than previously assumed

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Section: Nod2 and Crohn Diseasementioning

confidence: 99%

“…BS/EOS is usually considered as an autoinflammatory disorder characterized by the usual triad of granulomatous arthritis, uveitis and dermatitis which develop very early (before 4 years) [85].…”

Section: Nod2 and Crohn Diseasementioning

confidence: 99%

The protein Nod2: An innate receptor more complex than previously assumed

Lecat

Piette

Legrand-Poels

2010

Biochemical Pharmacology

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“…4 We suggest that the increase in HLA-DRpositive cells in the Blau iris stroma reflects an increase in HLA-DR expressing APCs. Given their spindle shape and their negative CD68 staining, the HLA-DR positive cells in our specimen likely represent proliferating iris dendritic cells that also express CD8.…”

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confidence: 73%

“…3 NOD2 protein is expressed in the antigen-presenting cells (APCs) 4 and also in vascular endothelium of the iris, ciliary body, and choroid. 5,6 It specifically recognizes muramyl dipeptide, a protein contained in the peptidoglycan of nearly all gram-positive and gram-negative bacteria, and subsequently activates the innate immune response that stimulates neutrophil influx and releases antibacterial peptides.…”

mentioning

confidence: 99%

“…5,6 It specifically recognizes muramyl dipeptide, a protein contained in the peptidoglycan of nearly all gram-positive and gram-negative bacteria, and subsequently activates the innate immune response that stimulates neutrophil influx and releases antibacterial peptides. 4 NOD2 mutations in Blau syndrome have been shown to constitutively activate both innate immunity through the NF-κB pathway, and adaptive immunity through T-lymphocytic activation, resulting in granulomatous inflammation. 3,7,8 IL-17, a cytokine product of Th17 cells, was identified in systemic granulomas of Blau patients, suggesting a role of these cells in the pathophysiology of Blau syndrome.…”

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confidence: 99%

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