NOD Mice Recapitulate the Cardiac Disturbances Observed in Type 1 Diabetes

Schleier, Ygor; Moreno-Loaíza, Óscar; Alarcón, Maria Micaela López; Martins, Eduarda Lopes; Cabral, Bruno; Ramos, Isalira Peroba; Galina, Antônio; Medei, Emiliano

doi:10.1007/s12265-020-10039-y

Cited by 3 publications

(3 citation statements)

References 64 publications

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“…18 More recently, shortterm variability of the QT interval has been proposed as a sensitive indicator of repolarization instability and a more reliable predictor of ventricular arrhythmias and SCD, and was also shown to be increased in individuals with impaired glucose tolerance. 20 Animal models have confirmed the increased arrhythmia susceptibility in the setting of DM and pre-DM, [21][22][23][24] and have demonstrated in vivo and ex vivo repolarization disturbances in addition to action potential prolongation on the cardiomyocyte level. 25 Obesity.…”

Section: Ventricular Arrhythmias and Scd In Diabetic And Obese Patientsmentioning

confidence: 99%

Sudden Cardiac Death in Diabetes and Obesity: Mechanisms and Therapeutic Strategies

Remme

2022

Canadian Journal of Cardiology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Ventricular Arrhythmias and Scd In Diabetic And Obese Patientsmentioning

confidence: 99%

Sudden Cardiac Death in Diabetes and Obesity: Mechanisms and Therapeutic Strategies

Remme

2022

Canadian Journal of Cardiology

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“…The calculated P/E control ratio in diabetic heart mitochondria was close to 1, indicating that OXPHOS equals the ET capacity and lack of respiratory reserve [ 28 , 57 ]. In contrast, in NOD mice, a model of T1D, Schleier et al reported that heart mitochondria showed higher RCR and lower LEAK respiration with no change in maximal OXPHOS compared with their controls, which suggests that the diabetic mitochondria are better coupled in this experimental model [ 58 ].…”

Section: Effects Of Diabetes On Mitochondrial Respiration In Animal S...mentioning

confidence: 99%

Impairment of Mitochondrial Respiration in Metabolic Diseases: An Overview

Avram

Merce

Hâncu

et al. 2022

IJMS

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Mitochondrial dysfunction has emerged as a central pathomechanism in the setting of obesity and diabetes mellitus, linking these intertwined pathologies that share insulin resistance as a common denominator. High-resolution respirometry (HRR) is a state-of-the-art research method currently used to study mitochondrial respiration and its impairment in health and disease. Tissue samples, cells or isolated mitochondria are exposed to various substrate-uncoupler-inhibitor-titration protocols, which allows the measurement and calculation of several parameters of mitochondrial respiration. In this review, we discuss the alterations of mitochondrial bioenergetics in the main dysfunctional organs that contribute to the development of the obese and diabetic phenotypes in both animal models and human subjects. Herein we review data regarding the impairment of oxidative phosphorylation as integrated mitochondrial function assessed by means of HRR. We acknowledge the critical role of this method in determining the alterations in oxidative phosphorylation occurring in the early stages of metabolic pathologies. We conclude that there is a mutual two-way relationship between mitochondrial dysfunction and insulin insensitivity that characterizes these diseases.

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“…Higher respiratory ratio, decreased complex IV expression. Increased arrhythmia frequency [ 84 , 213 , 244 ] Akita Whole animal ECC, isolated hearts, myocytes, and mitochondria Modest ↓ or = / ND ↓ or = / ↓ = / ↑ ↓SERCA2a expression = PLN expression = or ↓ PLN phosp ↓SR Ca 2+ content ↓ reduced cell surfaces LTCCs ↑ expression = activity Conserved or reduced ventricular dimensions. Increased palmitate and reduced glucose oxidation.…”

Section: Ca 2+ Mishandling In Diabetic Cardiomyopathymentioning

confidence: 99%

Ca2+ mishandling and mitochondrial dysfunction: a converging road to prediabetic and diabetic cardiomyopathy

Giusti

Palomeque

Mattiazzi

2022

Pflugers Arch - Eur J Physiol

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Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as valvular or coronary artery dysfunctions. Since the impact of DM on cardiac function is rather silent and slow, early stages of diabetic cardiomyopathy, known as prediabetes, are poorly recognized, and, on many occasions, cardiac illness is diagnosed only after a severe degree of dysfunction was reached. Therefore, exploration and recognition of the initial pathophysiological mechanisms that lead to cardiac dysfunction in diabetic cardiomyopathy are of vital importance for an on-time diagnosis and treatment of the malady. Among the complex and intricate mechanisms involved in diabetic cardiomyopathy, Ca 2+ mishandling and mitochondrial dysfunction have been described as pivotal early processes. In the present review, we will focus on these two processes and the molecular pathway that relates these two alterations to the earlier stages and the development of diabetic cardiomyopathy. Supplementary Information The online version contains supplementary material available at 10.1007/s00424-021-02650-y.

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NOD Mice Recapitulate the Cardiac Disturbances Observed in Type 1 Diabetes

Cited by 3 publications

References 64 publications

Sudden Cardiac Death in Diabetes and Obesity: Mechanisms and Therapeutic Strategies

Sudden Cardiac Death in Diabetes and Obesity: Mechanisms and Therapeutic Strategies

Impairment of Mitochondrial Respiration in Metabolic Diseases: An Overview

Ca2+ mishandling and mitochondrial dysfunction: a converging road to prediabetic and diabetic cardiomyopathy

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