NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies

Liu, Peng; Lu, Ziwen; Liu, Lanlan; Li, Ruyan; Liang, Zhaoming; Shen, Manman; Han, Xu; Ren, Dewan; Ji, Mengchen; Yuan, Sirui; Shang, Dongsheng; Zhang, Yibang; Liu, Hanqing

doi:10.1016/j.phymed.2019.152925

Cited by 118 publications

(72 citation statements)

References 179 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the NLR signalling pathway was highly enriched. NLRs are important in regulating inflammation‐associated mechanisms as they sense pathogen‐associated molecular patterns and activate other signalling regulators in response to the activated cytokines (Saxena and Yeretssian, 2014; Liu et al ., 2019). Although studies related to the direct relationship between NLRs and osmoregulation are limited, the possibility exists that environmental salinity may alter the immune system in fishes (Cuesta et al ., 2005; Tort, 2011).…”

Section: Discussionmentioning

confidence: 99%

Osmotic stress induces gut microbiota community shift in fish

Lai

Lin

Tam

et al. 2020

Environmental Microbiology

View full text Add to dashboard Cite

Summary Alteration of the gut microbiota plays an important role in animal health and metabolic diseases. However, little is known with respect to the influence of environmental osmolality on the gut microbial community. The aim of the current study was to determine whether the reduction in salinity affects the gut microbiota and identify its potential role in salinity acclimation. Using Oryzias melastigma as a model organism to perform progressive hypotonic transfer experiments, we evaluated three conditions: seawater control (SW), SW to 50% sea water transfer (SFW) and SW to SFW to freshwater transfer (FW). Our results showed that the SFW and FW transfer groups contained higher operational taxonomic unit microbiota diversities. The dominant bacteria in all conditions constituted the phylum Proteobacteria, with the majority in the SW and SFW transfer gut comprising Vibrio at the genus level, whereas this population was replaced by Pseudomonas in the FW transfer gut. Furthermore, our data revealed that the FW transfer gut microbiota exhibited a reduced renin–angiotensin system, which is important in SW acclimation. In addition, induced detoxification and immune mechanisms were found in the FW transfer gut microbiota. The shift of the bacteria community in different osmolality environments indicated possible roles of bacteria in facilitating host acclimation.

show abstract

Section: Discussionmentioning

confidence: 99%

Osmotic stress induces gut microbiota community shift in fish

Lai

Lin

Tam

et al. 2020

Environmental Microbiology

View full text Add to dashboard Cite

show abstract

“…Thus, we found that depletion of linc00342 retarded cell proliferation, accelerated cell apoptosis, and signi cantly reduced migration and invasion ability in KIRC cells. KEGG analysis showed linc00342-related genes were enriched in several important signaling pathways -MAPK, mTOR, insulin, NOD-like receptor, Wnt, and GnRH -that are reported to play key roles in many malignancies [27][28][29][30][31][32]. The effect of these KEGG pathways on the progress of KICC was not explored in our current study.…”

Section: Discussionmentioning

confidence: 70%

Linc00342 serves as a diagnostic and prognostic biomarker in Kidney Renal Clear Cell Carcinoma:A Comprehensive Study Based on Data mining, Clinical Analysis, and in vitro Validation

Guan

Ping

2020

Preprint

View full text Add to dashboard Cite

Background: Kidney renal clear cell carcinoma (KIRC), as the most common type of renal cancer, has a high mortality and recurrence rate due to the fact that many patients are in advanced stage at the time of consultation. Finding a biological marker for early-stage KIRC has become a top priority. Recently, accumulating studies have shown that lncRNA can serve as a target for diagnosis and prognosis of malignancy. However, the involvement and mechanism of linc00342 has never been researched in KIRC. The aim of this study was to investigate the diagnostic and prognostic value of linc00342 in KIRC, and to explore the effects of linc00342 on the biological functions of KIRC cells.Methods: We downloaded the linc00342 expression data and clinical information of KIRC from the TCGA database and constructed a prognostic prediction model. In vitro, the effect of knocking down linc00342 on KIRC cell proliferation, apoptosis, metastasis, and invasion was measured by colony-formation assay, flow cytometric analysis, wound-healing assay and Transwell assay, respectively.Results: Our nomogram predictive model suggested linc00342 can serve as an independent prognostic factor for KIRC. GO functional analysis and KEGG pathway analysis showed linc00342 was involved in various biological functions of KIRC, and experiments in vitro verified this. In vitro, linc00342 was overexpressed in KIRC cells as shown by RT-qPCR. Moreover, we found that linc00342 can inhibit cell apoptosis and promote cell proliferation, invasion, and migration.Conclusions: Our study is the first to examine the diagnostic and prognostic value of linc00342 in KIRC and provides new ideas for the treatment of KIRC.

show abstract

“…Inflammation, as a hallmark of carcinoma, affects all stages of tumorigenesis. Inflammasomes are a large complex of NOD-like receptors called NLRs, which have been identified as vital regulators in inflammation-related carcinogenesis, angiogenesis, metastasis, oxidative stress, cancer cell transformation, and chemoresistance [ 48 , 49 ]. The activity of NLRs is directly regulated by some miRNAs [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of preoperative inflammation-based predictors in patients with bladder carcinoma after radical cystectomy

et al. 2021

View full text Add to dashboard Cite

Aims Emerging evidence has related inflammation-based biomarkers to numerous carcinomas, including bladder carcinoma (BC). However, the role of inflammatory biomarkers in the prognosis of BC remains inconclusive. This study aimed to compare preoperative plasma fibrinogen (PF) and other inflammatory biomarkers such as the platelet–lymphocyte ratio (PLR), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), C-reactive protein (CRP) level, and serum albumin level to predict the prognosis of patients with BC. Methods This article focused on a retrospective analysis of 175 patients with newly diagnosed BC who were admitted to our hospital from March 2005 to March 2016. Of these BC patients, 136 had undergone radical cystectomy (RC). Results According to multivariate analysis, high PF level was an independent predictor of overall survival (OS) in 136 BC patients receiving RC (HR = 3.759; P = 0.011), but not for all 175 BC patients. Combining the NLR and PF values showed higher predictive accuracy for OS than NLR or PF alone (P < 0.05). Additionally, for 136 BC patients who had undergone RC, a close relationship was found between high PF levels (≥3.39 g/L) and lymph node metastasis (P = 0.011) and clinical T stage (P = 0.015). Furthermore, PF was a superior prognostic factor compared with the LMR, PLR, CRP, and albumin values in 136 BC patients who had undergone RC (P < 0.001). Conclusions The preoperative PF level may be a prognostic biomarker; and when combined with the NLR, it can improve the predictive ability of the survival of BC patients, particularly of BC patients who underwent RC.

show abstract

NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies

Cited by 118 publications

References 179 publications

Osmotic stress induces gut microbiota community shift in fish

Osmotic stress induces gut microbiota community shift in fish

Linc00342 serves as a diagnostic and prognostic biomarker in Kidney Renal Clear Cell Carcinoma:A Comprehensive Study Based on Data mining, Clinical Analysis, and in vitro Validation

Prognostic value of preoperative inflammation-based predictors in patients with bladder carcinoma after radical cystectomy

Contact Info

Product

Resources

About