Nocturnal wheezing in children--management with controlled-release aminophylline.

Bulugahapitiya, D T; Hebron, B. S.

doi:10.1136/bmj.283.6288.436-a

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BMJ

1981

DOI: 10.1136/bmj.283.6288.436-a

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Nocturnal wheezing in children--management with controlled-release aminophylline.

D T Bulugahapitiya¹,

B. S. Hebron²

Abstract: administered parenterally show an increase of the usual cardiovascular effects.2 In this way the pulmonary ventilation: perfusion ratio is significantly altered and it is the main cause of the hypoxaemic effect.3 Thirdly, the hypoxaemic effect is less when the patient has been treated for a few days with 3-adrenergic agents, probably because of pharmacological tolerance.

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1985

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Treatment of nocturnal asthma in children with a single dose of sustained‐release theophylline taken after supper

Pedersen

1985

Clin Experimental Allergy

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In a placebo-controlled, double-blind cross-over study of 2x3 weeks' duration, twenty-four children with stable asthma who were wheezing during the night, were treated with a single dose of sustained-release iheophylline (SRT) taken after supper.The mean serum theophylline levels 4 and 12 hr after dosing were 7 7 and 11 2 mg/1, respectively. Few side-effects were seen. The mean morning peak expiratory flow (PEF) was significantly higher during SRT treatment (244+ 11 1/min) than during placebo treatment (207+ 12 1/min) (/*<0 001). The mean difTerence between morning and evening PEF was reduced from 20 7 to 86"o by treatment with SRT (/'<0 001). Theophylline significantly reduced the severity of attacks of bronchoconstriction during the night as judged by PEF measurement and use of extra bronchodilator treatment per attack. The response to inhaled terbutaline was increased during SRT treatment compared with that in the placebo period, however pre-treatment PEF did differ significantly between the two periods. The number of acute asthma attacks during the night, the number of symptom-free nights and the use of extra bronchodilators during the night were all significantly improved by SRT treatment (/'<0 001). Seventeen children correctly identified the SRT period whilst six children showed no preference for either period. A single dose of SRT taken after supper is an effective treatment for nocturnal asthma in children.

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Treatment of nocturnal asthma in children with a single dose of sustained‐release theophylline taken after supper

Pedersen

1985

Clin Experimental Allergy

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Nocturnal wheezing in children--management with controlled-release aminophylline.

Cited by 1 publication

References 3 publications

Treatment of nocturnal asthma in children with a single dose of sustained‐release theophylline taken after supper

Treatment of nocturnal asthma in children with a single dose of sustained‐release theophylline taken after supper

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