Nocturnal urinary dopamine excretion is reduced in otherwise healthy subjects with periodic leg movements in sleep

Cohrs, Stefan; Guan, Zhenghua; Pohlmann, Kathrin; Jordan, Wolfgang; Pilz, Jürgen; Rüther, Eckart; Rodenbeck, Andrea

doi:10.1016/j.neulet.2004.02.056

Cited by 15 publications

(12 citation statements)

References 13 publications

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“…These results are consistent with previous work associating sleep disturbance with dopamine deficiency in other medical populations (Cohrs et al, 2004; Hornyak et al, 2012; Sasai et al, 2012). Dopamine deficiencies in WLWH could possibly lead to increased lethargy, as well as cognitive impairment (Kumar et al, 2011).…”

Section: Discussionsupporting

confidence: 93%

“…Firstly, we examined connections among sleep, dopamine, and CD4 count using cross-sectional data; thus, the directionality of the associations we found could not be discerned. Furthermore, given the previous findings (Cohrs et al, 2004; Hornyak et al, 2012; Sasai et al, 2012), it is possible that the connections among sleep, dopamine, and CD4 count in WLWH could be reciprocal. † Future work should examine these connections utilizing a longitudinal design.…”

Section: Discussionmentioning

confidence: 89%

“…Following with this work, recent research has revealed disturbed sleep to be significantly associated with lower dopamine levels, which in turn may lead to increased sleepiness and lethargy. Sleep disturbances in particular, such as periodic leg movements, are associated with decreased levels of dopamine (Cohrs et al, 2004). Multiple studies also demonstrate that dopamine agonists improve symptoms of sleep disturbances in patients with conditions such as rapid-eye movement sleep behavior disorder and restless leg syndrome, indicating that dopamine decrements may accompany sleep disruption (Hornyak et al, 2012; Sasai et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…While overall sleep quality may play a significant role in both dopamine level and immune status, we aimed to examine sleep disturbance in particular, due to the specific connections previously found between sleep disturbances and abnormalities in dopamine in other conditions such as restless legs syndrome, Parkinson’s disease, and schizophrenia (Cohrs et al, 2004; Sarkar et al, 2010). The aims of the current study are first, to compare overall sleep quality and sleep disturbance as independent correlates of urinary dopamine concentration and immune status in women living with HIV (WLWH).…”

Section: Introductionmentioning

confidence: 99%

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Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV

Seay

McIntosh

Fekete

et al. 2013

Psychoneuroendocrinology

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Background Sleep disturbance is associated with dopamine dysregulation, which can negatively impact immune status. Individuals living with HIV experience more sleep difficulties, and poor sleep may compound immune decrements associated with HIV infection. Little research has examined associations between sleep, dopamine, and immune status (CD4 count) in individuals with HIV. As ethnic minority women living with HIV (WLWH) are at heightened risk for HIV disease progression, we related sleep reports to both CD4 count and dopamine levels in a cohort of ethnic minority WLWH. Methods Participants were 139 low-income WLWH (ages 20–62; 78.3% African-American or Caribbean) who reported both overall sleep quality and sleep disturbance on the Pittsburgh Sleep Quality Index (PSQI). CD4 count and HIV viral load were measured via morning peripheral venous blood samples, and concentrations of dopamine were measured via 24-hour urine collection. Covariates included HIV viral load, length of time since HIV diagnosis, HAART adherence, perceived stress and depression. Results After controlling for all covariates, greater sleep disturbance was associated with significantly lower CD4 count (β = −.20, p = .03) and lower levels of dopamine (β = −.25, p = .04). Poorer overall sleep quality was marginally associated with lower CD4 count (β = −.16, p = .08), and was not associated with dopamine. Conclusion Our analyses suggest that sleep disturbance is independently related with immune status and dopamine levels in WLWH. Lower levels of dopamine may indicate neuroendocrine dysregulation and may impact immune and health status. Results highlight sleep disturbance rather than overall sleep quality as potentially salient to neuroendocrine and immune status in ethnic minority WLWH.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV

Seay

McIntosh

Fekete

et al. 2013

Psychoneuroendocrinology

View full text Add to dashboard Cite

show abstract

“…There are very few studies of movement-related sleep disorders in SZ, and estimates of RLS and PLMS range between 13% to 21% [29]. The exact neurobiological mechanisms are not understood, although one hypothesis proposes that dopamine deficiency is a likely cause [30]. This has given rise to the "depletion" theory which posits that antipsychotics in SZ may precipitate such problems through the blocking of dopamine (DA) [27].…”

Section: Movement-related Sleep Disordersmentioning

confidence: 99%