Nocturnal sleep study in multiple sclerosis: Correlations with clinical and brain magnetic resonance imaging findings

Ferini‐Strambi, Luigi; Filippi, Massimo; Martinelli, Vittorio; Oldani, Alessandro; Rovaris, Marco; Zucconi, Marco; Comı, Gıancarlo; Smirne, Salvatore

doi:10.1016/0022-510x(94)90035-3

Cited by 145 publications

(84 citation statements)

References 20 publications

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“…Generally, PLMS have been found in approximately 80-90% of patients with RLS (37,38) and previously, PLMS was associated with sleep disruption in MS (39). Neurophysiological examination, such as polysomnography, is essential for the diagnosis of PLMS and can contribute to diagnosis in uncertain RLS cases.…”

Section: Discussionmentioning

confidence: 93%

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Moreira

Damasceno

Medeiros

et al. 2008

Braz J Med Biol Res

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27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6), excessive daytime sleepiness by the Epworth Sleepiness Scale (ESS >10) and clinical disability by the Expanded Disability Status Scale (EDSS). Forty-four patients (32 women) aged 14 to 64 years (43 ± 14) with disease from 0.4 to 23 years (6.7 ± 5.9) were evaluated. Thirty-five were classified as relapsing-remitting, 5 as primary progressive and 4 as secondary progressive. EDSS varied from 0 to 8.0 (3.6 ± 2.0). RLS was detected in 12 cases (27%). Patients with RLS presented greater disability (P = 0.01), poorer sleep (P = 0.02) and greater levels of fatigue (P = 0.03). Impaired sleep was present in 23 (52%) and excessive daytime sleepiness in 3 cases (6.8%). Fatigue was present in 32 subjects (73%) and was associated with clinical disability (P = 0.000) and sleep quality (P = 0.002). Age, gender, disease duration, MS pattern, excessive daytime sleepiness and the presence of upper motor neuron signs were not associated with the presence of RLS. Fatigue was best explained by clinical disability and poor sleep quality. Awareness of RLS among health care professionals may contribute to improvement in MS management.]]>

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Section: Discussionmentioning

confidence: 93%

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Moreira

Damasceno

Medeiros

et al. 2008

Braz J Med Biol Res

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“…In animal study, lesions of the pontine tegmentum prevented the normal suppression of muscle tone in REM sleep [19]. Moreover, it has been suggested that brainstem lesions were related to the secondary PLM [20]. Therefore, repetitive involuntary leg movements similar to PLM in our patient 3 may be associated with disinhibition of the inhibitory reticulospinal system secondary to a pontine tegmental lesion.…”

Section: Discussionmentioning

confidence: 72%

“…At this time, spontaneous rapid hip flexion associated with knee flexion and ankle dorsiflexion, and symmetric alternating leg movements resembling stepping emerged without provocation. The interval between the leg movements was [15][16][17][18][19][20] …”

Section: Patientmentioning

confidence: 99%

Repetitive involuntary leg movements in patients with brainstem lesions involving the pontine tegmentum: evidence for a pontine inhibitory region in humans

Lee

Yong

et al. 2005

Parkinsonism & Related Disorders

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“…10,12,14 In SCI, traumatic and nontraumatic injuries can sever key neural signaling pathways responsible for regulating and maintaining sleep. 10,15 Similarly in MS, demyelination and neurodegeneration [16][17][18][19] throughout the brain and spinal cord can damage neural structures and axonal projections that may be involved in sleep and sleep related disorders such as periodic limb movement 20 and sleep related breathing disorders. 21 For both SCI and MS, damage to the brain or cervical spinal cord can decrease secretion of melatonin, a neurohormone important for initiating sleep and maintaining circadian sleep-wake cycles.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Sleep Problems in Individuals with Spinal Cord Injury and Multiple Sclerosis

Fogelberg

Hughes

Vitiello

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: Sleep problems are common in spinal cord injury (SCI) and multiple sclerosis (MS). However, the degree to which sleep problems differ between these distinct clinical populations has not been evaluated. In this study, we examined self-reported sleep problems in individuals with SCI and those with MS, and compared these clinical groups on the Medical Outcomes Study Sleep Scale (MOS-SS). Methods: Participants were 1,677 individuals (SCI = 581; MS = 1,096) enrolled in longitudinal study of self-reported health outcomes in SCI and MS. Univariate and multivariate analysis of covariance examined group differences on global sleep problems and domain-specific subscales of the MOS-SS. Results: Individuals with SCI reported an average of 30 fewer min of sleep per night (Sleep Quantity subscale) and significantly greater difficulty initiating and maintaining sleep (Sleep Disturbance subscale) compared to individuals with MS. However, groups did not differ on global sleep problems (Sleep Problems Index 9). Conclusions: Although global sleep problems are more common in SCI and MS than in the general population, these groups exhibit differing sleep problem profiles, and thus may require unique treatment approaches to address the specific domains of sleep affected. For individuals with SCI, an additional focus on increasing sleep quantity and reducing sleep disruptions may be warranted.

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Nocturnal sleep study in multiple sclerosis: Correlations with clinical and brain magnetic resonance imaging findings

Cited by 145 publications

References 20 publications

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients

Repetitive involuntary leg movements in patients with brainstem lesions involving the pontine tegmentum: evidence for a pontine inhibitory region in humans

Comparison of Sleep Problems in Individuals with Spinal Cord Injury and Multiple Sclerosis

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