Nocturnal Salivary Fluoride Bioavailability After Brushing with a High-fluoride Dentifrice

Lopes, Maria Suzi de Sousa; Santana, Guilherme Bandeira; Macena, Niciane Soares; Carvalho, Guereth Alexsanderson Oliveira; Mota, Brenda Izabela Santana; Prado, Vera Lúcia Gomes; Vale, Gláuber Campos

doi:10.1007/s12011-021-02658-6

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…The fluoride level in the oral fluids, including saliva, is considered a proxy variable for caries controlling effect of fluoride applications, including fluoride toothpaste [11]. Most published studies on high-dosage fluoride toothpaste have reported the salivary fluoride concentration after a single or very few toothbrushing sessions and/or only during the first few hours after exposure(s) [12][13][14][15][16][17][18][19][20]. These studies show that a single or few exposures to high-fluoride toothpaste result in higher salivary fluoride levels during the first few hours after exposure than seen after the use of toothpaste with up to 1500 ppm fluoride.…”

Section: Introductionmentioning

confidence: 99%

Salivary fluoride levels after daily brushing with 5000 ppm fluoride toothpaste: A randomised, controlled clinical trial

Larsen

Nyvad

Bælum

2023

European J Oral Sciences

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This study explored salivary fluoride levels following toothbrushing with 5000 and 1450 ppm fluoride toothpaste and determined the decline in salivary fluoride levels following the return from 5000 to 1450 ppm fluoride toothpaste. The study was a randomised, controlled double‐blind parallel clinical trial (n = 24/group) measuring salivary fluoride five times during a 3‐week trial phase involving 2×/day use of 5000 or 1450 ppm fluoride toothpaste, and five times during an ensuing 2‐week wash‐out phase where all participants used 1450 ppm toothpaste. Salivary fluoride was measured using a fluoride electrode and data were analysed using multilevel mixed‐effects linear regression. Baseline salivary fluoride geometric means were 0.014 and 0.016 ppm for the 1450 and 5000 ppm groups, while the values at the end of the trial phase were 0.023 and 0.044 ppm, respectively. During the trial phase, except at baseline, differences between groups were statistically significant. The salivary fluoride levels for the 5000 ppm group remained statistically significantly higher than for the 1450 ppm group only at the first measurement in the wash‐out phase (≈30 h after the last 5000 ppm brushing), indicating that higher salivary fluoride levels resulting from use of 5000 ppm are sustained only as long as the brushing habit continues.

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Section: Introductionmentioning

confidence: 99%

Salivary fluoride levels after daily brushing with 5000 ppm fluoride toothpaste: A randomised, controlled clinical trial

Larsen

Nyvad

Bælum

2023

European J Oral Sciences

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Salivary fluoride bioavailability after use of high‐fluoride dentifrices with different compositions: A short‐term randomized clinical trial

Macena

Santana

Carvalho

et al. 2023

Int J Dental Hygiene

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ObjectiveThe objective of the study was to evaluate the kinetics of salivary F bioavailability after the use of high‐fluoride dentifrices with different compositions and their amount of total soluble fluoride (TSF).MethodsA short‐term clinical randomized trial was performed in which 15 adult participants were randomly allocated into three groups: 5000 ppm F‐dentifrice, 5000 ppm F‐dentifrice + TCP (tri‐calcium phosphate) and 1450 ppm F‐dentifrice. Unstimulated saliva was collected at different times: baseline (before toothbrushing), immediately after brushing/water rinsing and at 5, 15 and 30 min and 1, 2, 4, 8 and 12 h after brushing. The TSF in dentifrices and saliva samples was analysed using an ion‐specific electrode. For statistical analysis, the paired t‐test and Kruskal–Wallis were used with Dunn's post‐test with a 95% confidence interval.ResultsThere was no significant difference between the declared TSF and that found in 5000 ppm F‐dentifrice and 1450 ppm F‐dentifrice (p ≥ 0.13); however, in the 5000 ppm F‐dentifrice + TCP, approximately 500 ppm less TSF was observed (p = 0.0024). The area under the curve (AUC, μg F/ml min−1) of both high‐fluoride dentifrices (321.7 ± 84.0 and 223.6 ± 55.1 for the one without and with TCP, respectively) was higher than the conventional one (89.97 ± 15.6) attesting a higher F‐bioavailability (p = 0.04). Furthermore, they were able to provide F‐salivary levels higher than the baseline for up to 2 h, while this time was 1 h for the 1450 ppm F‐dentifrice (p ≤ 0.003).ConclusionBoth high‐fluoride dentifrices similarly increased the salivary‐F bioavailability in comparison with 1450 ppm F‐dentifrice, despite the lower TSF presented by the dentifrice containing TCP.

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Nocturnal Salivary Fluoride Bioavailability After Brushing with a High-fluoride Dentifrice

Cited by 2 publications

References 26 publications

Salivary fluoride levels after daily brushing with 5000 ppm fluoride toothpaste: A randomised, controlled clinical trial

Salivary fluoride levels after daily brushing with 5000 ppm fluoride toothpaste: A randomised, controlled clinical trial

Salivary fluoride bioavailability after use of high‐fluoride dentifrices with different compositions: A short‐term randomized clinical trial

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