Nocturnal hypoxaemia in patients with chronic obstructive pulmonary disease: who should be treated and how?

The decrease of the respiratory muscle endurance after the use of verapamil is in line with experiments in animal diaphragms. However, the nocturnal saturation did not change. This finding suggests that the effect found on diaphragm endurance is of no clinical significance and that verapamil can be given to COPD patients without risk of worsening nocturnal saturation. However, this must be confirmed by future larger scale studies.

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Verapamil causes decreased diaphragm endurance but no decrease of nocturnal O 2 saturation in patients with chronic obstructive pulmonary disease

Broeders¹,

Heijdra²,

Smits

et al. 2000

European Journal of Clinical Pharmacology

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Nocturnal hypoxaemia in patients with chronic obstructive pulmonary disease: who should be treated and how?

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References 28 publications

Verapamil causes decreased diaphragm endurance but no decrease of nocturnal O 2 saturation in patients with chronic obstructive pulmonary disease

Verapamil causes decreased diaphragm endurance but no decrease of nocturnal O 2 saturation in patients with chronic obstructive pulmonary disease

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