Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Ahmed, Fathelrahman

doi:10.4172/2168-9857.1000191

Cited by 2 publications

(3 citation statements)

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“…This finding is in agreement with Portacarrero et al who showed that children and adolescents with SCD had non-monosymptomatic and primary enuresis in 58% and 86% of the cases, respectively. Another recent study also demonstrated an increased prevalence of primary non-monosymptomatic enuresis in SCD patients (24).…”

Section: Discussionmentioning

confidence: 81%

Prevalence of enuresis and its impact in quality of life of patients with sickle cell disease

et al. 2019

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Introduction: Evidence indicates an increase in the prevalence of enuresis in individuals with sickle cell disease. The present study aims to evaluate the prevalence and impact of enuresis on quality of life in individuals with sickle cell disease. Materials and Methods: This cross-sectional study evaluated individuals with sickle cell disease followed at a reference clinic, using a questionnaire designed to evaluate the age of complete toilet training, the presence of enuresis and lower urinary tract, and the impact on quality of life of these individuals. Results: Fifty children presenting SCD (52% females, mean age ten years) were included in the study. Of those, 34% (17/50) presented as HbSC, 56% with HbSS (28/50), 2% Sα-thalassemia (1/5) and 8% the type of SCD was not determined. The prevalence of enuresis was 42% (21/50), affecting 75% of subjects at fi ve years and about 15% of adolescents at 15 years of age. Enuresis was classifi ed as monosymptomatic in 33.3% (7/21) and nonmonosymptomatic in 66.6% (14/21) of the cases, being primary in all subjects. Nocturia was identifi ed in 24% (12/50), urgency in 20% (10/50) and daytime incontinence 10% (5/50) of the individuals. Enuresis had a signifi cant impact on the quality of life of 67% of the individuals. Conclusion: Enuresis was highly prevalent among children with SCD, and continues to be prevalent throughout early adulthood, being more common in males. Primary nonmonosymptomatic enuresis was the most common type, and 2/3 of the study population had a low quality of life.

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Section: Discussionmentioning

confidence: 81%

Prevalence of enuresis and its impact in quality of life of patients with sickle cell disease

et al. 2019

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“…Another recent postulation is that SCA-related enuresis may be due to atonic detrusor muscle which results in an underactive bladder with defective emptying mechanism. This abnormality is thought to be a consequence of chronic bladder ischemia caused by recurrent cycles of ischemia-perfusion injury triggered by vasoocclusion [39]. Evidence for this hypothesis was reported by some authors who studied the urinary bladder function in a transgenic sickle cell disease murine model and found these pathophysiologic changes: reduced urine output, inability to produce the typical bladder contraction and emptying, lower detrusor muscle, small bladder contraction and reduced urethral contraction [40].…”

Section: Nocturnal Enuresis In Sca: Hypotheses On Etiopathogenesismentioning

confidence: 95%

“…The association of low vitamin levels with OSAS is reportedly mediated through promotion of adenotonsillar hypertrophy, chronic rhinitis and/or myopathy of airway muscle [55]. Better still, low vitamin D levels may result in nocturnal enuresis through obstructive sleep apnea, sleep fragmentation and nocturnal polyuria, which all occur in children with SCA [39].…”

Section: Nocturnal Enuresis In Sca: Hypotheses On Etiopathogenesismentioning

confidence: 99%

Nocturnal Enuresis in Children with Sickle Cell Anemia

Uwaezuoke¹,

Eneh²,

Ezenwosu³

et al. 2019

Contemporary Pediatric Hematology and Oncology

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Sickle cell anemia (SCA) is the commonest hemoglobin disorder among the black population worldwide. Children with SCA may eventually end up with end-organ complications: the kidneys being one of the most frequently affected organs. The renal complications arise from medullary ischemia and infarction leading to features of tubular dysfunction such as hyposthenuria and renal tubular acidosis. Early in life, children with SCA may present with hyposthenuria: one of the earliest renal defects in the disease which results in an obligatory urine output of more than 2 l in a day. The symptomatic manifestation as nocturnal polyuria is thought to be the reason for nocturnal enuresis observed in these children. In spite of the more prevalent occurrence of nocturnal enuresis in children with SCA than in their non-SCA colleagues, its precise underlying mechanisms still remain controversial, with divergent conclusions regarding its pathogenesis. However, the consensus is now tilting towards a multifactorial etiopathogenesis in affected children. This book chapter aims to discuss the epidemiologic perspectives of nocturnal enuresis in SCA, as well as the current hypotheses on the etiopathogenesis of this complication.

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Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Cited by 2 publications

References 116 publications

Prevalence of enuresis and its impact in quality of life of patients with sickle cell disease

Prevalence of enuresis and its impact in quality of life of patients with sickle cell disease

Nocturnal Enuresis in Children with Sickle Cell Anemia

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