Nocturnal Enuresis and Daytime Wetting: A Multicentric Trial with Oxybutynin and Desmopressin

Treatment of childhood nocturnal enuresis: an examination of clinically relevant principles

“…Moffatt et al [20] comprehensively reviewed many published papers on randomized clinical trials of desmopressin and found, compared with placebo, that desmopressin was signi®-cantly better in 13 of the 14 studies. With a more selected population of children with primary NE, Caione et al [21] found a 79% success rate after the administration of desmopressin. Devitt et al [22] showed that the response to desmopressin was closely related to the level and variability of AVP.…”

Comparing the efficacy of desmopressin and oxybutynin combination therapy and desmopressin monotherapy in children with primary nocturnal enuresis; a randomized clinical trial

“…In mono-symptomatic form, patients have only nocturnal enuresis, but in non-mono-symptomatic, in addition to nocturnal enuresis, patients may have some other symptoms such as frequent urination, dysuria and daytime incontinence (3)(4)(5). The etiology of primary nocturnal enuresis is not yet known, but some factors such as stimulatory disorders during sleep, excessive production of urine at night and reduced bladder capacity during sleep are influential factors (5).…”

“…It is recommended to take a urinary system sonography test to check urinary system anatomy. To evaluate the bladder function, urine residual measurement after voiding is recommended too (3). After a confirmed diagnosis of nocturnal enuresis, the disease should be treated.…”

New directions for the endocrine treatment of bedwetting

“…Although there have been reports of combination therapy (desmopressin plus anticholinergic), this method of treatment has been reported primarily in children with nocturnal enuresis and lower urinary tract symptoms or overactive bladder [15]. There are only a few studies examining combination therapy in children with desmopressin-resistant monosymptomatic nocturnal enuresis in the literature [16][17][18][19].…”