Nocturnal enuresis: a suggestion for a European treatment strategy

Läckgren, Göran; Hjälmås, K; Gool, Jan van; Gontard, Alexander von; Gennaro, M. De; Lottmann, Henri; Terho, Pirjo

doi:10.1080/08035259950169396

Cited by 69 publications

(58 citation statements)

References 51 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the high incidence, a few studies have addressed the pathophysiology of NE [5,6]. Several pathophysiological mechanisms have been proposed [7], e.g.…”

Section: Introductionmentioning

confidence: 99%

Does monosymptomatic enuresis exist? A molecular genetic exploration of 32 families with enuresis/incontinence

Loeys

Hoebeke²,

Raes³

et al. 2002

BJU International

View full text Add to dashboard Cite

Objectives To confirm linkage to microsatellite markers on chromosome 8q, 12q, 13q and 22q in families with nocturnal enuresis/incontinence segregating with an autosomal dominant pattern, and to determine if there is an association between the clinical subtype and these linked loci. Patients and methods Families with at least three members with nocturnal enuresis in two generations were included in the study. The index patient was 7 years old and had evidence of bladder dysfunction; all other family members were 5 years old. Bladder dysfunction in the index patients was documented by video‐urodynamics when indicated. A nycthemeral rhythm of diuresis was documented in all index patients. The clinical diagnosis of all family members was based on a questionnaire on voiding problems and micturition habits, uroflowmetry, measurement of functional bladder capacity and nocturnal diuresis. Linkage was analysed using an autosomal dominant model with a gene frequency equal to 0.05 and a penetrance of 0.9. Results Thirty‐two families with nocturnal enuresis/incontinence (one with four, 25 with three and six with two generations) were included. The mean number of persons included per family was 10 and on average five members were symptomatic. Linkage of nocturnal enuresis to a region on chromosome 22q11 was found in nine families, to 13q13–14 in six and to 12q in four. There was no convincing evidence for linkage to chromosome 8q. Clinical findings in the proband and their family members with possible linkage to a given locus were heterogeneous, and hence no clear genotype/phenotype correlation could be postulated. Conclusion These findings support the hypothesis of the genetic and phenotypic heterogeneity of nocturnal enuresis/incontinence. Putative linkage was confirmed to the same chromosomal loci as in previous studies of ‘monosymptomatic’ enuresis and different phenotypes were linked to the same loci.

show abstract

“…Despite the high incidence, a few studies have addressed the pathophysiology of NE [5,6]. Several pathophysiological mechanisms have been proposed [7], e.g.…”

Section: Introductionmentioning

confidence: 99%

Does monosymptomatic enuresis exist? A molecular genetic exploration of 32 families with enuresis/incontinence

Loeys

Hoebeke²,

Raes³

et al. 2002

BJU International

View full text Add to dashboard Cite

show abstract

“…PNE is thought to be caused by reduced nocturnal bladder capacity, nocturnal polyuria, awakening problem or a combination of these factors (Hunsballe et al, 1995;Loening-Baucke, 1997;Wolfish et al, 1997;Lackgren et al, 1999;Kawauchi et al, 2002). Also genetic susceptibility, constipation and hypercalciuria have been attributed to the etiology of PNE whereas psychosocial factors, urinary tract infections, constipation, diabetes, neurogenic bladder are reported as causes of SNE (Pace et al, 1999;Robson and Leung, 2000;Sureshkumar et al, 2000;Raes et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Enuresis: Is bedwetting really isolated or not?

Genç

Özkaya

Özden

et al. 2013

jecm

View full text Add to dashboard Cite

Materials and methodsAll records of the patients who applied for the first time to Ondokuz Mayis University (OMU) between January 2006 and June 2012 with only complaint of bedwetting were evaluated retrospectively and those aged between 5 and 17 were enrolled in the study. All children were evaluated with a complete medical history, comprehensive physical examination and were questioned about voiding habits. Three-day bladder diary about the frequency and volume of urine was obtained from patients. Etiological factors such as emotional stress, family history, and constipation were also investigated. Causes of emotional stress were investigated with conversations with the family and the patient one by one at outpatients' clinic. Family history of enuresis was questioned by physician for genetic susceptibility. Constipation was evaluated according to Rome III diagnostic criteria for functional gastrointestinal

show abstract

“…Since the first choice of therapy should be the one most acceptable to the whole family [1]and due to the lack of a prospective randomized trial comparing the alternative option using laser acupuncture with the well–established desmopressin therapy, we performed an ethical committee approved study. Some single studies on different forms of acupuncture, either using needles or electrostimulation, showed surprinsingly high success rates of up to 98.2% [8, 9, 10].…”

Section: Discussionmentioning

confidence: 99%

“…Modern classification divides the affected children into several subgroups, according to history, symptom pattern, presence of nocturnal polyuria, and response to treatment with the vasopressin analogue desmopressin [1]. This paper refers to the specific subgroup of children suffering from primary nocturnal enuresis with normal daytime voiding patterns and high nighttime urine production.…”

Section: Introductionmentioning

confidence: 99%