Nocturnal but not Diurnal Hypertension Is Associated to Insulin Resistance Markers in Subjects With Normal or Mildly Elevated Office Blood Pressure

Salazar, Martín R.; Espeche, Walter G; Stavile, Rodolfo N.; Disalvo, Liliana; Tournier, Andrea; Sisnieguez, Betty C Leiva; Varea, Ana; Sisnieguez, Carlos Enrique Leiva; March, Carlos; Carbajal, Horacio A

doi:10.1093/ajh/hpx096

Cited by 8 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood pressure varies diurnally, rising during the day and dipping at night. The loss of this pattern due to disrupted circadian rhythm is correlated with insulin resistance and cardiovascular disease [44, 45]. It is unclear why the current study found a significant association only between sleep timing and systolic blood pressure.…”

Section: Discussionmentioning

confidence: 79%

Associations of sleep patterns with metabolic syndrome indices, body composition, and energy intake in children and adolescents

Kelly

Brychta

et al. 2019

Pediatric Obesity

View full text Add to dashboard Cite

Background: Self-reported short sleep duration is associated with greater risk for metabolic syndrome (MetS), obesity, and higher energy intake (EI). However, studies of these associations in children using objective methods are sparse. Objectives: To determine the associations for sleep patterns with MetS indices, body composition, and EI using objective measures in children. Methods: Free-living sleep and physical activity were measured in 125 children (aged 8–17y, BMI-z=0.57±1.0, 55% female) using wrist-worn actigraphs for 14 nights. Blood pressure, fasting blood levels of lipids, insulin, glucose, waist circumference, and body composition (DXA) were obtained during outpatient visits. EI was assessed during an ad libitum buffet meal. Results: Later weekday and weekend bedtimes were associated with higher systolic blood pressure (ps<.05). Sleep duration and bedtime were not significantly associated with other components of MetS, body composition, or EI. Short sleepers (duration <7h) consumed a greater percentage of carbohydrates than those with adequate (≥7h) sleep (p<.05). Conclusion: Indicators of sleep duration were variably associated with children’s eating patterns and risk for chronic disease. Prospective data are needed to determine whether these indicators of sleep quality represent unique or shared risk factors for poor health outcomes.

show abstract

Section: Discussionmentioning

confidence: 79%

Associations of sleep patterns with metabolic syndrome indices, body composition, and energy intake in children and adolescents

Kelly

Brychta

et al. 2019

Pediatric Obesity

View full text Add to dashboard Cite

show abstract

“…38 Salazar et al reported that nocturnal, but not diurnal hypertension, was associated with insulin resistance in untreated normotensive and mildly hypertensive patients. 39 Yan et al showed that a reverse dipping BP pattern was independent predictor of lacunar infarction in hypertensive patients. 40 The authors did not separately investigate the effect of nocturnal BP, but only 24-h BP.…”

Section: Target Organ Damagementioning

confidence: 99%

<p>Isolated Nocturnal Hypertension: What Do We Know and What Can We Do?</p>

Tadić¹,

Cuspidi²,

Mancia³

2020

IBPC

View full text Add to dashboard Cite

Nocturnal hypertension has been recognized as a significant risk factor for cardioand cerebrovascular diseases. Blood pressure (BP) monitoring significantly increased our awareness of nocturnal hypertension and studies revealed its influence on target organ damage. Nocturnal hypertension is associated with nonphysiological 24-h BP patterns, which consider inadequate drop or even increment of nighttime BP in comparison with daytime BP (nondipping and reverse dipping). Nevertheless, investigations showed that nocturnal hypertension was a predictor of adverse outcome independently of circadian BP pattern. There are still many uncertainties regarding diagnosis, mechanisms and treatment of nocturnal hypertension. There is a small difference between American and European guidelines in cutoff values defining nocturnal hypertension. Pathophysiology is also not clear because many conditions such as diabetes, metabolic syndrome, obesity, sleep apnea syndrome, and renal diseases are related to nocturnal hypertension and nonphysiological circadian BP pattern, but mechanisms of nocturnal hypertension still remain speculative. Therapeutic approach is another important issue and chronotherapy provided the best results so far. There are studies which showed that some groups of antihypertensive medications are more effective in regulation of nocturnal BP, but it seems that the timing of drug administration has a crucial role in the reduction of nighttime BP and conversion of circadian patterns from nonphysiologic to physiologic. Follow-up studies are necessary to define clinical benefits of nocturnal BP reduction and restoring unfavorable 24-h BP variations to physiological variant.

show abstract

“…Asimismo, otro mecanismo de la utilización de terapia antiretrovirales, sería a través de mecanismos relacionados al daño endotelial y marcadores metabólicos como insulinorresistencia 12---14 . Esto es consistente la demostración previa que la insulinorresistencia tiene mayor relación con la HTA nocturna que con la diurna 15 . Basados en estos supuestos; tanto la HTA nocturna aislada como la HTA sostenida, podrían aparecer Existen varias limitaciones en este estudio que deben ser reconocidas: Primero, la cohorte de individuos con VIH analizada es pequeña en comparación con estudios de riesgo cardiovascular sobre población general.…”

Section: Discussionunclassified

Hipertensión nocturna aislada en individuos con el virus de la inmunodeficiencia humana

Espeche

Salazar

Minetto

et al. 2022

Hipertensión y Riesgo Vascular

View full text Add to dashboard Cite

Nocturnal but not Diurnal Hypertension Is Associated to Insulin Resistance Markers in Subjects With Normal or Mildly Elevated Office Blood Pressure

Abstract: Nocturnal but not diurnal hypertension was related to higher levels of 3 insulin resistance markers in normotensive and untreated mildly hypertensive adults; this relationship seems partially independent of obesity.

Cited by 8 publications

References 23 publications

Associations of sleep patterns with metabolic syndrome indices, body composition, and energy intake in children and adolescents

Associations of sleep patterns with metabolic syndrome indices, body composition, and energy intake in children and adolescents

<p>Isolated Nocturnal Hypertension: What Do We Know and What Can We Do?</p>

Hipertensión nocturna aislada en individuos con el virus de la inmunodeficiencia humana

Contact Info

Product

Resources

About