Nocturnal blood pressure in primary open‐angle glaucoma

Pillunat, Karin R; Spoerl, Eberhard; Jasper, Carolin S.; Furashova, Olga; Hermann, Cosima; Borrmann, Anne; Passauer, Jens; Middeke, Martin; Pillunat, Lutz E

doi:10.1111/aos.12740

Cited by 27 publications

(16 citation statements)

References 41 publications

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“…DOPP is especially useful for displaying the lowest OPP values and is regarded as an independent risk factor for OAG. A recent study suggested that nocturnal BP could be a modifiable risk factor for glaucoma severity and progression [ 63 ]. Nocturnal hypotension is caused primarily by sleep, presumably owing to sympathetic withdrawal.…”

Section: Poag and Hypotensionmentioning

confidence: 99%

The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension

Chung

Hwang

Lee

2015

BioMed Research International

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Glaucoma is the second leading cause of blindness worldwide. Although the mechanism of the development of primary open-angle glaucoma (POAG) is not fully understood, elevated intraocular pressure (IOP) is considered the most important risk factor. Several vascular factors have also been identified as risk factors and can lead to hypoperfusion of the optic nerve head and thus may play an important role in the pathogenesis and progression of POAG. The results of the present study suggest that both high and low blood pressure (BP) are associated with an increased risk of POAG based on a comprehensive literature review. Elevated BP is associated with elevated IOP, leading to increased risk of glaucoma, but excessive BP lowering in glaucoma patients may cause a drop in ocular perfusion pressure (OPP) and subsequent ischemic injury. The relationship between IOP, OPP, and BP suggests that the relationship between BP and glaucoma progression is U-shaped.

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Section: Poag and Hypotensionmentioning

confidence: 99%

The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension

Chung

Hwang

Lee

2015

BioMed Research International

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“…In contrast, more recent reports, as Maracaibo Aging Study, suggest that it is not the physiological nocturnal hypotension that triggers optic nerve damage, but rather the non-physiological overdipping pattern of more than 20% [14]. Similar findings were presented by Pillunat et al [23], who suggested that normotensive (but not hypertensive) patients with an over-dipping pattern of ABP have an increased risk of glaucoma progression.…”

Section: Low Blood Pressure and Glaucomamentioning

confidence: 57%

Blood pressure and glaucoma: At the crossroads between cardiology and ophthalmology

et al. 2019

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Glaucoma is an optic nerve neuropathy of undetermined cause. Although many mechanisms are thought to be involved in the development and progression of the disease, only an increased intraocular pressure has been established as a clinically significant modifiable risk factor. Nevertheless, up to 40% of patients develop glaucoma without evidence of increased intraocular pressure. Ample evidence suggests that alterations in the control of arterial blood might negatively affect optic nerve function. However, evidence-based guidelines on the management of arterial blood pressure in glaucoma patients are lacking. Regrettably, intraocular pressure is generally not included as a secondary end-point in clinical trials on arterial hypertension. Considering the relative simplicity of intraocular pressure measurements and large number of patients included in hypertension studies, the benefits of including intraocular pressure as a secondary end-point could be of a great value for improving care for glaucoma patients. Therefore, closer collaboration between cardiologists and ophthalmologists is needed.

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“…DOPP is particularly useful in displaying the lowest OPP values and is seen as a free risk factor for OAGs. A continuous report suggests that evening BP could be a modifiable risk factor for the truth and growth of glaucoma [9].…”

Section: Discussionmentioning

confidence: 99%

Distribution of Ocular Perfusion Pressure in Hypertensive Patients

Shruthi

2020

JPRI

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Aim: To describe the distribution of ocular perfusion pressure hypertensive patients. Design: Cross-sectional observation study. Materials and Methods: Hospital-based, case control cross-sectional study conducted on 100 patients. Systolic and diastolic blood pressure (SBP and DBP) was measured with a Mercury Sphygmomanometer. Mean ocular perfusion pressure (MOPP) = ⅔ (mean arterial pressure − IOP), where mean arterial pressure (MAP) = DBP + ⅓ (SBP − DBP), systolic perfusion pressure (SPP) = SBP – IOP and diastolic perfusion pressure (DPP) = DBP − IOP was calculated. Results: High values of diastolic BP (>90 mmHg) and low values of OPP (<40 mmHg) were associated to an increased risk of confirmed POAG. Conclusion: There is a close relationship between OPP and confirmed glaucoma in hypertensive patients.

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Nocturnal blood pressure in primary open‐angle glaucoma

Cited by 27 publications

References 41 publications

The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension

The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension

Blood pressure and glaucoma: At the crossroads between cardiology and ophthalmology

Distribution of Ocular Perfusion Pressure in Hypertensive Patients

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