Nociceptors: Their Role in Body’s Defenses, Tissue Specific Variations and Anatomical Update

Николенко, В.Н.; Шеломенцева, Е М; Tsvetkova, Maria M; Abdeeva, Elina; Db, Giller; Babayeva, Juliya V; Ачкасов, Е. Е.; Gavryushova, Liliya V.; Sinelnikov, Mikhail Y.

doi:10.2147/jpr.s348324

Cited by 6 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Herein, we also found that the expression level of PIEZO2 was positively correlated with pain markers, NPY and TAC1. PIEZO2 was demonstrated to be localized to low-threshold mechanoreceptors (LTMs) in sensory dorsal root ganglion neurons [ 31 ], which have been proven to produce substance P [ 32 ]. Besides, PIEZO2 was also localized to dental primary afferent neurons in trigeminal ganglions [ 20 ], which exhibited higher expression of LTM marker NPY [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Expression patterns of mechanosensitive ion channel PIEZOs in irreversible pulpitis

Yang,

Lin,

et al. 2024

BMC Oral Health

View full text Add to dashboard Cite

Background Mechanosensitive ion channel PIEZOs have been widely reported to involve inflammation and pain. This study aimed to clarify expression patterns of PIEZOs and their potential relations to irreversible pulpitis. Materials and methods Normal pulp tissues (n = 29) from patients with impacted third molars and inflamed pulp tissues (n = 23) from patients with irreversible pulpitis were collected. Pain levels were assessed using a numerical rating scale. PIEZO expressions were measured using real-time PCR and then confirmed using GEO datasets GSE77459, immunoblot, and immunohistochemistry staining. Correlations of PIEZO mRNA expression with inflammatory markers, pain markers, or clinical pain levels were evaluated using Spearman’s correlation analysis. Univariate analysis was conducted to analyze PIEZO expressions based on pain description and clinical examinations of cold test, percussion, palpation, and bite test. Results Compared with normal pulp tissues, mRNA expression levels of PIEZO1 were significantly increased in inflamed pulp tissues, while PIEZO2 was significantly decreased, which was further confirmed in GSE77459 and on a protein and histological level. The positive correlation of the mRNA expression levels between PIEZO1 and inflammatory markers, as well as between PIEZO2 and pain markers, was verified. PIEZO2 expression was also positively correlated with pain levels. Besides, irreversible pulpitis patients who reported continuous pain and who detected a positive response to cold stimulus exhibited a higher expression level of PIEZO2 in the inflamed pulp tissues. By contrast, patients reporting pain duration of more than one week showed a higher expression level of PIEZO1. Conclusions This study demonstrated the upregulation of PIEZO1 and the downregulation of PIEZO2 in irreversible pulpitis and revealed the potential relation of PIEZO1 and PIEZO2 to inflammation and pain. These findings suggested that PIEZOs might play critical roles in the progression of irreversible pulpitis and paved the way for further investigations aimed at novel therapies of irreversible pulpitis by targeting PIEZOs.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression patterns of mechanosensitive ion channel PIEZOs in irreversible pulpitis

Yang,

Lin,

et al. 2024

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…Compared to what is observed with rectangular waveforms [ 35 ], this more selective activation could contribute to lower adaptation rates by limiting potential sensory gating when larger pools of afferents are stimulated [ 36 ]. Moreover, the polymodal fibres are associated with secondary, mechanical, and dull pain sensations that are common in musculoskeletal disease and injury [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

Moving in pain ‐ A preliminary study evaluating the immediate effects of experimental knee pain on locomotor biomechanics

Charlton,

Chang,

Hou

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Pain changes how we move, but it is often confounded by other factors due to disease or injury. Experimental pain offers an opportunity to isolate the independent effect of pain on movement. We used cutaneous electrical stimulation to induce experimental knee pain during locomotion to study the short-term motor adaptions to pain. While other models of experimental pain have been used in locomotion, they lack the ability to modulate pain in real-time. Twelve healthy adults completed the single data collection session where they experienced six pain intensity conditions (0.5, 1, 2, 3, 4, 5 out of 10) and two pain delivery modes (tonic and phasic). Electrodes were placed over the lateral infrapatellar fat pad and medial tibial condyle to deliver the 10 Hz pure sinusoid via a constant current electrical stimulator. Pain intensity was calibrated prior to each walking bout based on the target intensity and was recorded using an 11-point numerical rating scale. Knee joint angles and moments were recorded over the walking bouts and summarized in waveform and discrete outcomes to be compared with baseline walking. Knee joint angles changed during the swing phase of gait, with higher pain intensities resulting in greater knee flexion angles. Minimal changes in joint moments were observed but there was a consistent pattern of decreasing joint stiffness with increasing pain intensity. Habituation was limited across the 30–90 second walking bouts and the electrical current needed to deliver the target pain intensities showed a positive linear relationship. Experimental knee pain shows subtle biomechanical changes and favourable habituation patterns over short walking bouts. Further exploration of this model is needed in real-world walking conditions and over longer timeframes to quantify motor adaptations.

show abstract

Heterogeneous Integration of Memristive and Piezoresistive MDMO‐PPV‐Based Copolymers in Nociceptive Transmission with Fast and Slow Pain for an Artificial Pain‐Perceptual System

Tsao,

Chang,

et al. 2024

Small

View full text Add to dashboard Cite

Nociceptive pain perception is a remarkable capability of organisms to be aware of environmental changes and avoid injury, which can be accomplished by specialized pain receptors known as nociceptors with 4 vital properties including threshold, no adaptation, relaxation, and sensitization. Bioinspired systems designed using artificial devices are investigated to imitate the efficacy and functionality of nociceptive transmission. Here, an artificial pain‐perceptual system (APPS) with a homogeneous material and heterogeneous integration is proposed to emulate the behavior of fast and slow pain in nociceptive transmission. Retention‐differentiated poly[2‐methoxy‐5‐(3,7‐dimethyoctyoxyl)‐1,4‐phenylenevinylene] (MDMO‐PPV) memristors with film thicknesses of 160 and 80 nm are manufactured and adopted as A‐δ and C nerve fibers of nociceptor conduits, respectively. Additionally, a nociceptor mimic, the ruthenium nanoparticles (Ru‐NPs)‐doped MDMO‐PPV piezoresistive pressure sensor, is fabricated with a noxiously stimulated threshold of 150 kPa. Under the application of pricking and dull noxious stimuli, the current flows predominantly through the memristor to mimic the behavior of fast and slow pain, respectively, in nociceptive transmission with postsynaptic potentiation properties, which is analogous to biological pain perception. The proposed APPS can provide potential advancements in establishing the nervous system, thus enabling the successful development of next‐generation neurorobotics, neuroprosthetics, and precision medicine.

show abstract

Nociceptors: Their Role in Body’s Defenses, Tissue Specific Variations and Anatomical Update

Cited by 6 publications

References 46 publications

Expression patterns of mechanosensitive ion channel PIEZOs in irreversible pulpitis

Expression patterns of mechanosensitive ion channel PIEZOs in irreversible pulpitis

Moving in pain ‐ A preliminary study evaluating the immediate effects of experimental knee pain on locomotor biomechanics

Heterogeneous Integration of Memristive and Piezoresistive MDMO‐PPV‐Based Copolymers in Nociceptive Transmission with Fast and Slow Pain for an Artificial Pain‐Perceptual System

Contact Info

Product

Resources

About