Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain

Koyama, Tetsuo; Tanaka, Yusuke; Mikami, Atsushi

doi:10.1097/00001756-199808030-00044

Cited by 164 publications

(77 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This interpretation is supported by other studies indicating that the ACC contributes to pain-related learning. Several in vivo electrophysiological studies have shown that individual ACC neurons (some of them characterized as noci-responsive) can acquire responses to environmental cues that predict a painful stimulus (38)(39)(40). Moreover, lesions of area 24b in the rabbit disrupt a conditioned decrease in latency to avoid a noxious stimulus (7).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

Johansen

Fields²,

Manning³

2001

Proc. Natl. Acad. Sci. U.S.A.

584

459

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Electrophysiological studies lend support to this view of ACC processing. First, neurons in the ACC respond both to noxious stimuli and cues that predict a noxious stimulus (8,13,14,(38)(39)(40). Interestingly, one study examined response properties of individual ACC neurons to both a pain-predictive cue and a noxious stimulus (39).…”

Section: Discussionmentioning

confidence: 99%

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

Johansen

Fields²,

Manning³

2001

Proc. Natl. Acad. Sci. U.S.A.

584

459

View full text Add to dashboard Cite

“…It is typically seen in the shoulders and carpal tunnels of those who propel themselves in wheelchairs and therefore use their shoulders as hips. 64 Lal in 1998 65 reported on shoulder joint degenerative changes in 72% of a sample of paraplegics. If the pain is due to nerve compression, electrophysiological studies as well as MR can aid in diagnosis.…”

Section: Secondary Overuse or Pressure Syndromesmentioning

confidence: 99%

Pain following spinal cord injury

2001

View full text Add to dashboard Cite

Chronic pain is an important problem following spinal cord injury (SCI) and is a major impediment to eective rehabilitation. The reported prevalence of chronic SCI pain is variable but averages 65% with around one third of these people rating their pain as severe. The mechanisms responsible for the presence of pain are poorly understood. However, evidence from clinical observations and the use of animal models of SCI pain suggests that a number of processes may be important. These include functional and structural plastic changes in the central nervous system following injury, with changes in receptor function and loss of normal inhibition resulting in an increased neuronal excitability. A number of speci®c types of SCI pain can be distinguished based on descriptors, location and response to treatment. Nociceptive pain can arise from musculoskeletal structures and viscera and neuropathic pain can arise from spinal cord and nerve damage. The role of psychological and environmental factors also needs to be considered. Accurate identi®cation of these pain types will help in selecting appropriate treatment approaches. Current treatments employ a variety of pharmacological, surgical, physical and psychological approaches. However, evidence for many of the treatments in use is still limited. It is hoped that future research will identify eective treatment strategies that accurately target speci®c mechanisms. Spinal Cord (2001) 39, 63 ± 73Keywords: spinal cord injuries; pain; neuropathic pain; paraplegia; tetraplegia Historical overviewChronic pain is a major problem in those who have sustained a spinal cord or cauda equina injury.1 These patients usually have devastating neurological de®cits. A signi®cant proportion also suers from chronic pain. Riddoch 2 addressed the problem of pain after SCI in his 1917 paper although Munro's classic paper on spinal cord injuries in 1943 did not even mention the issue of chronic pain.3 After WW II, Botterell et al. 4described chronic pain in 12/103 SCI patients and 11 of these 12 had cauda equina injuries. Kuhn 5 reported that 0.234% of the injuries in WW II involved the spinal cord and that 22.5% of 113 patients with SCI had chronic pain. Prevalence/incidenceSince then, there have been numerous reports regarding the incidence and prevalence of pain following SCI. In 1962, Kaplan 6 attempted to classify SCI pains and stated that 37% of 52 SCI patients had chronic pain 1 year after injury and this increased to 50% by 5 years after injury. Davis 7 reported an incidence of 27% in 471 SCI patients. Richards et al.8 claimed that 77% of 88 SCI patients had chronic pain and that psychosocial variables predicted about 1/2 of the variance. Woolsey 9 identi®ed less than a 20% incidence of chronic pain in a group of 100 SCI patients.A number of more recent studies have all contributed data on the incidence and prevalence of pain after SCI.10 ± 17 The methodology and the patient population being studied appear to greatly in¯uence the reported incidence of SCI pain but across studies it appears...

show abstract

“…The prefrontal cortex (PFC), anterior insula, and anterior cingulate cortex (ACC) are activated during the anticipation of pain, but their exact role in pain expectation remains poorly delineated (9)(10)(11)(12). Moreover, the neural mechanisms by which conscious predictions about the magnitude of pain influence the experience of pain remain poorly understood and largely unexploited in the treatment of pain.…”

mentioning

confidence: 99%

The subjective experience of pain: Where expectations become reality

Koyama

McHaffie

Laurienti

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

608

408

View full text Add to dashboard Cite

Our subjective sensory experiences are thought to be heavily shaped by interactions between expectations and incoming sensory information. However, the neural mechanisms supporting these interactions remain poorly understood. By using combined psychophysical and functional MRI techniques, brain activation related to the intensity of expected pain and experienced pain was characterized. As the magnitude of expected pain increased, activation increased in the thalamus, insula, prefrontal cortex, anterior cingulate cortex (ACC) and other brain regions. Pain-intensityrelated brain activation was identified in a widely distributed set of brain regions but overlapped partially with expectation-related activation in regions, including the anterior insula and ACC. When expected pain was manipulated, expectations of decreased pain powerfully reduced both the subjective experience of pain and activation of pain-related brain regions, such as the primary somatosensory cortex, insular cortex, and ACC. These results confirm that a mental representation of an impending sensory event can significantly shape neural processes that underlie the formulation of the actual sensory experience and provide insight as to how positive expectations diminish the severity of chronic disease states.functional MRI ͉ mental imagery ͉ placebo ͉ psychophysical T he experience of a sensory event is highly subjective and can vary substantially from one individual to the next (1). Much of this individual variation may result from the manner in which past experience and future predictions about a stimulus are used to interpret afferent information. Consistent pairing of environmental cues with sensory events provides a learned historical context that is critically important for the prediction and processing of future sensations (2, 3). However, expectations that are inconsistent with sensory information can dramatically alter the sensory experience. In the case of pain, positive expectations can powerfully reduce the subjective experience of pain evoked by a consistently noxious stimulus, whereas negative expectations may result in the amplification of pain (4-7). Furthermore, expectations in which there is a high degree of certainty as to the outcome may activate descending control systems to diminish pain, whereas expectations associated with uncertain outcomes may amplify pain (8).The prefrontal cortex (PFC), anterior insula, and anterior cingulate cortex (ACC) are activated during the anticipation of pain, but their exact role in pain expectation remains poorly delineated (9-12). Moreover, the neural mechanisms by which conscious predictions about the magnitude of pain influence the experience of pain remain poorly understood and largely unexploited in the treatment of pain. At the most fundamental level, expectation-induced modulation of pain must necessarily engage three neural processes. First, an active mental representation of an impending event must be formulated by incorporating past information with the present context and future implica...

show abstract

Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain

Cited by 164 publications

References 4 publications

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

Pain following spinal cord injury

The subjective experience of pain: Where expectations become reality

Contact Info

Product

Resources

About