Nociceptive fingertip stimulation inhibits synergistic motoneuron pools in the human upper limb

Leis, A. Arturo; Stokić, Dobrivoje S.; Fuhr, Peter; Kofler, Markus; Kronenberg, Martina F.; Wissel, Jörg; Glocker, Franz Xaver; Seifert, C.; ̌Sťetkářová, Ivana

doi:10.1212/wnl.55.9.1305

Cited by 71 publications

(38 citation statements)

References 25 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Secondly, the CSP in humans is less expressed and has shorter duration in proximal than in distal limb muscles (Inghilleri et al 1997;Leis et al 2000;Serrao et al 2001). Nevertheless, we obtained robust CSPs in the proximal hiprelated motor nerve that we recorded from for technical reasons.…”

Section: Discussionmentioning

confidence: 99%

“…A single stimulus to a cutaneous nerve can induce a CSP with a similar time course in several agonist and antagonist muscle groups (Inghilleri et al 1997;Leis et al 2000). In addition, CSPs may be followed by a rebound of motor activity (Kumru et al 2009;Uncini et al 1991).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, CSPs may be followed by a rebound of motor activity (Kumru et al 2009;Uncini et al 1991). It is agreed that this complex response to cutaneous stimulation is mediated by spinal circuits (Logigian et al 1999) that normally serve to rapidly interrupt activities in synergistic muscles during reaching and grasping (Leis et al 2000) as a defensive mechanism to protect the limb (Inghilleri et al 1997).…”

Section: Introductionmentioning

confidence: 99%

“…Latency and duration of the CSP depend on stimulus intensity (Kofler 2003;Leis et al 2000;Serrao et al 2001;Shefner and Logigian 1993;Uncini et al 1991), on the intensity of voluntary muscle contraction (Serrao et al 2001;Uncini et al 1991), the cutaneous nerve stimulated, and the muscles tested (Inghilleri et al 1997;Kofler 2003;Leis et al 2000). These parameters of the CSP can be useful as supplementary evaluation of the functional state of peripheral nerves and local spinal sensory motor networks in disease (Leis et al 2011;Onal et al 2010;Oz et al 2011;Svilpauskaite et al 2006).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle

2012

View full text Add to dashboard Cite

The transient suppression of motor activity in the spinal cord after a cutaneous stimulus is termed the cutaneous silent period (CSP). It is not known if CSP is due to suppression of the premotor network or direct inhibition of motoneurons. This issue was examined by intracellular recordings from motoneurons in the isolated carapace-spinal cord preparation from adult turtles during rhythmic scratch-like reflex. Electrical stimulation of cutaneous nerves induced CSP-like suppression of motor nerve firing during rhythmic network activity. The stimulus that generated the CSP-like suppression of motor activity evokes a polysynaptic compound synaptic potential in motoneurons and suppressed their firing. This compound synaptic potential was hyperpolarizing near threshold for action potentials and was associated with a substantial increase in conductance during the CSP in the motor pool. These results show that direct postsynaptic inhibition of motoneurons contributes to the CSP.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle

2012

View full text Add to dashboard Cite

show abstract

“…Furthermore, CSPs are known to have different characteristics in various muscles, e.g., in the abductor pollicis brevis muscle, the EMG suppression is more pronounced than in the first dorsal interosseous, and digit II stimulation induces a CSP with shorter onset latency in both muscles than digit V stimulation. 6,11 However, our intention was to document a readily-available method that may aid the electromyographer when routine procedures fail. Our main goal was to present a qualitative rather than quantitative technique, indicating that some A-␦ fibers remained intact.…”

Section: Discussionmentioning

confidence: 99%

Preserved cutaneous silent periods in severe entrapment neuropathies

Kofler¹,

Fröhlich²,

Saltuari³

2003

Muscle and Nerve

View full text Add to dashboard Cite

Noxious digital nerve stimulation during isometric contraction of hand muscles leads to transient suppression of the electromyographic activity, the so-called cutaneous silent period (CSP), which is mostly due to a spinal reflex mediated by A-delta fibers. We investigated two patients with carpal tunnel syndrome (CTS) and two patients with ulnar entrapment at the elbow (UNE), in whom routine sensory conduction studies failed to document afferent fiber continuity across the lesion site. In three patients, motor nerve conduction studies and electromyography failed to demonstrate intact efferent fibers. Noxious stimulation of digit II elicited distinct CSPs in ulnar-innervated hand muscles in both patients with CTS, and stimulation of digit V evoked CSPs in median-innervated hand muscles in both UNE patients. The presence of a CSP can only be explained by preserved A-delta fibers crossing the respective lesion site. Thus, preserved CSPs may serve to document residual nerve continuity in severe entrapment neuropathies when fast-conducting fibers are so compromised that their continuity cannot be detected by standard electrodiagnostic techniques.

show abstract

Cutaneous silent periods

Floeter

2003

Muscle and Nerve

117

View full text Add to dashboard Cite

The cutaneous silent period (CSP) refers to the brief interruption in voluntary contraction that follows strong electrical stimulation of a cutaneous nerve. The CSP is a protective reflex that is mediated by spinal inhibitory circuits and is reinforced in part by parallel modulation of the motor cortex. This review summarizes current understanding of the afferents and circuits that are responsible for producing CSPs; the utility of the CSP for investigating peripheral and central nervous system disorders; and the relationship between the CSP, other cutaneous reflexes, and peripheral silent periods.

show abstract

Nociceptive fingertip stimulation inhibits synergistic motoneuron pools in the human upper limb

Cited by 71 publications

References 25 publications

Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle

Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle

Preserved cutaneous silent periods in severe entrapment neuropathies

Cutaneous silent periods

Contact Info

Product

Resources

About