Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as decrease in hippocampal acetylcholine release in the rat

Hiramatsu, Masayuki; Miwa, Masaya; Hashimoto, Kazuki; Kawai, Satoko; Nomura, Nao

doi:10.1016/j.brainres.2007.12.008

Cited by 17 publications

(10 citation statements)

References 37 publications

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“…In mice, 0.5 to 5 nmol administered icv during the acquisition produced a decrease in the step-down latency during the retention test (Hiramatsu and Inoue 1999). A similar effect was observed for a dose of 0.5 nmol in the stepthrough version of the test in rats, this amnestic action being blocked by the co-administration of 1 nmol of [Nphe 1 ]N/OFQ(1-13)-NH2 (Hiramatsu et al 2008). Moreover icv doses of 1 and 4 nmol delayed the acquisition in a multi-trial version of IA in mice, and this effect was again prevented by [Nphe 1 ]N/OFQ(1-13)-NH2 (Liu et al 2007).…”

Section: N/ofq Affects Different Types Of Long-term Memorysupporting

confidence: 53%

The Nociceptin/Orphanin FQ System and the Regulation of Memory

Moulédous

2018

Handbook of Experimental Pharmacology

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Nociceptin/Orphanin FQ (N/OFQ) is an endogenous neuropeptide of 17 amino acids, related to opioid peptides but with its own receptor, distinct from conventional opioid receptors, the ORL1 or NOP receptor. The NOP receptor is a G protein-coupled receptor which activates Gi/o proteins and thus induces an inhibition of neuronal activity. The peptide and its receptor are widely expressed in the central nervous system with a high density of receptors in regions involved in learning and memory. This review describes the consequences of the pharmacological manipulation of the N/OFQ system by NOP receptor ligands on learning processes and on the consolidation of various types of long term memory. We also discuss the role of endogenous N/OFQ release in the modulation of learning and memory. Finally we propose several putative neuronal mechanisms taking place at the level of the hippocampus and amygdala and possibly underlying the behavioral amnestic or promnesic effects of NOP ligands.

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Section: N/ofq Affects Different Types Of Long-term Memorysupporting

confidence: 53%

The Nociceptin/Orphanin FQ System and the Regulation of Memory

Moulédous

2018

Handbook of Experimental Pharmacology

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“…Initial studies suggested a dose-dependent biphasic effect of an intrahippocampal infusion of N/OFQ, in which low doses (0.33 to 1nmol) enhanced memory in the water maze and high doses (>5nmol) resulted in an impairment (Redrobe et al, 2000; Sandin et al, 1997; Sandin et al, 2004). Interestingly, this effect is rescued by NOP receptor antagonists (Hiramatsu et al, 2008; Redrobe et al, 2000; Sandin et al, 2004). The impairment of learning and memory by a single dose of N/OFQ or NOP receptor agonists has been consistently reported in different tasks that are highly dependent on hippocampal and amygdala functioning, when N/OFQ or NOP receptor agonists are administered through different routes (See Table 1 for detailed information).…”

Section: Nociceptin and The Nociceptin Receptor In Learning And Mementioning

confidence: 98%

“…[Nphe1]nociceptin(1-13)NH2(Nphe), an NOP receptor antagonist, has been shown to inhibit cholinergic transmission in the hippocampus (Cavallini et al, 2003). Moreover, N/OFQ given i.c.v reduces the acetylcholine release in the rat hippocampus (Hiramatsu et al, 2008). Finally, NOP receptor ko mice present enhanced basal hippocampal acetylcholine release (Uezu et al, 2005).…”

Section: Interactions Of N/ofq-nop Receptor With Other Systems In mentioning

confidence: 99%

Nociceptin and the nociceptin receptor in learning and memory

Andero

2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Summary There are many processes in which the neuropeptide nociceptin/orphanin FQ (N/OFQ or nociceptin) is involved in the brain. The role of nociceptin in learning and memory holds promise in modulating these processes in health and disease in the human brain. This review summarizes the body of research focused on N/OFQ and its specific receptor, the nociceptin receptor (NOP receptor), in learning and memory, and its potential mechanisms of action, in which acetylcholine, NMDA receptor and noradrenaline may be critical. Finally, the association between NOP receptor and Posttraumatic stress disorder (PTSD), a psychiatric disorder with altered fear learning, is examined as one of the potential outcomes resulting from pathological consequences of dysregulation of N/OFQ-NOP receptor in the brain.

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“…Additional studies have reported a role for NOP receptor modulation of glutamate and GABA release within the lateral amygdala and cerebrocortex. N/OFQ and NOP receptors have also been shown to modulate acetylcholine release at cholinergic circuits (Uezu et al, 2005;Hiramatsu et al, 2008) in both pharmacological and genetic knockout studies. It is hypothesized that these effects impact learning and memory-related behaviors via changes in LTP and LTD within the hippocampus.…”

Section: B Effects Of Nociceptin Opioid Peptide Receptor Activation mentioning

confidence: 99%

Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

et al. 2016

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The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently discovered member of the opioid receptor family and, together with its endogenous ligand, N/OFQ, make up the fourth members of the opioid receptor and opioid peptide family. Because of its more recent discovery, an understanding of the cellular and behavioral actions induced by NOP receptor activation are less well developed than for the other members of the opioid receptor family. All of these factors are important because NOP receptor activation has a clear modulatory role on mu opioid receptor-mediated actions and thereby affects opioid analgesia, tolerance development, and reward. In addition to opioid modulatory actions, NOP receptor activation has important effects on motor function and other physiologic processes. This review discusses how NOP pharmacology intersects, contrasts, and interacts with the mu opioid receptor in terms of tertiary structure and mechanism of receptor activation; location of receptors in the central nervous system; mechanisms of desensitization and downregulation; cellular actions; intracellular signal transduction pathways; and behavioral actions with respect to analgesia, tolerance, dependence, and reward. This is followed by a discussion of the agonists and antagonists that have most contributed to our current knowledge. Because NOP receptors are highly expressed in brain and spinal cord and NOP receptor activation sometimes synergizes with mu receptor-mediated actions and sometimes opposes them, an understanding of NOP receptor pharmacology in the context of these interactions with the opioid receptors will be crucial to the development of novel therapeutics that engage the NOP receptor

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Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as decrease in hippocampal acetylcholine release in the rat

Cited by 17 publications

References 37 publications

The Nociceptin/Orphanin FQ System and the Regulation of Memory

The Nociceptin/Orphanin FQ System and the Regulation of Memory

Nociceptin and the nociceptin receptor in learning and memory

Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

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