Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

Meunier, Jean‐Claude

doi:10.1016/s0014-2999(97)01411-8

Cited by 366 publications

(203 citation statements)

References 95 publications

Supporting

Mentioning

191

Contrasting

Unclassified

Order By: Relevance

“…Moreover, in situ hybridization and immunohistochemical studies, in rodents, have demonstrated that both OP 4 / nociceptin mRNA and receptor protein are found in high concentrations in the hippocampus, brainstem and cortex, areas of the brain involved in higher functions including learning and memory processing (Henderson & McKnight, 1997;Meunier, 1997;Darland et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Redrobe

Calò

Guerrini

et al. 2000

British J Pharmacology

View full text Add to dashboard Cite

1 The present study was undertaken to investigate the e ects of the novel nociceptin receptor antagonist, [Nphe 1 ]-Nociceptin (1-13)-NH 2 (bilateral intrahippocampal injection, 50 nmole rat 71 ) on purported nociceptin-induced (bilateral intrahippocampal injection, 5 nmole rat 71 ) de®cits in spatial learning in the rat Morris water maze task. In addition, experiments were performed in an`open ®eld' to investigate possible peptide-induced changes in exploratory behaviour. 2 Nociceptin signi®cantly impaired the ability of the animal to locate the hidden platform throughout training (P50.001 versus control group). 3 Pretreatment with [Nphe 1 ]-Nociceptin (1-13)-NH 2 signi®cantly blocked nociceptin-induced impairment of spatial learning (P50.001 versus nociceptin group). 4 A probe trial revealed that vehicle-treated animals spent more time in the quadrant that had previously contained the hidden platform, whereas nociceptin-treated animals did not spend more time in any one quadrant. 5 Learning impairments were not attributable to non-speci®c de®cits in motor performance or change in exploratory behaviour. 6 Taken together, our results reveal that [Nphe 1 ]-Nociceptin (1-13)-NH 2 represents an e ective and useful in vivo antagonist at the nociceptin receptors involved in learning and memory.

show abstract

Section: Introductionmentioning

confidence: 99%

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Redrobe

Calò

Guerrini

et al. 2000

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…A fourth type of opioid receptor, termed opioid receptor-like 1 (ORL 1 ) (Mollereau et al, 1994), orphan opioid (Henderson & McKnight, 1997) or, tentatively, OP 4 receptor (Hamon, 1998), has been cloned by several groups in 1994 (for review, see Henderson & McKnight, 1997;Meunier, 1997). The heptadecapeptide nociceptin (also termed orphanin FQ) has been identi®ed as endogenous ligand at this receptor (Meunier et al, 1995;Reinscheid et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…The heptadecapeptide nociceptin (also termed orphanin FQ) has been identi®ed as endogenous ligand at this receptor (Meunier et al, 1995;Reinscheid et al, 1995). Despite the high structural resemblance of the ORL 1 receptor to the classical opioid receptors, most of the ligands at the classical opioid receptors have very low a nity for the ORL 1 receptor; another striking di erence to the classical opioid receptors is the fact that nociceptin elicits a hyperalgetic rather than an analgetic response in rodents (for review, see Henderson & McKnight, 1997;Meunier, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…Nociceptin inhibits transmitter release (determined directly or via the endorgan response) in a series of peripheral tissues, including the guinea-pig ileum and the rat and mouse vas deferens (for review, see Henderson & McKnight, 1997;Meunier, 1997). With respect to the CNS, Vaughan et al (1997) found that nociceptin, at a presynaptic site, inhibited the evoked fast GABAergic and glutamatergic postsynaptic currents in rat periaqueductal gray slices.…”

Section: Introductionmentioning

confidence: 99%

“…The inhibitory e ect of nociceptin on glutamate release was measured directly by Nicol et al (1996) in rat brain cortex slices. Furthermore, administration of nociceptin into the ventricle or the ventral tegmental area inhibited dopamine release in the nucleus accumbens of the anaesthetized rat (Murphy et al, 1996;1997). By contrast, nociceptin, administered intrastriatally to conscious rats, increased dopamine release in the striatum (Konya et al, 1998) and, when administered to the ventral tegmental area of the anaesthetized rat, facilitated GABA and glutamate release in this brain region (Murphy et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Further characterization of the ORL₁ receptor‐mediated inhibition of noradrenaline release in the mouse brain in vitro

Werthwein

Bauer

Nakazi

et al. 1999

British J Pharmacology

View full text Add to dashboard Cite

In conclusion, nociceptin inhibits noradrenaline release in the mouse cortex via ORL 1 receptors, which interact with presynaptic a 2 -autoreceptors on noradrenergic neurones. The e ect of nociceptin does not desensitize nor does it involve NO, prostanoids or adenosine. Nociceptin also attenuates noradrenaline release from several subcortical regions and serotonin release from cortical slices by a naloxone benzoylhydrazone-sensitive mechanism.

show abstract

Distribution of prepro-nociceptin/ orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems

et al. 1998

View full text Add to dashboard Cite

Nociceptin/orphanin FQ (N/OFQ) and its receptor share similarities to opioids and their receptors in terms of the molecular structure and signaling pathway, but the two systems exhibit different actions in vivo. To understand the mechanism of N/OFQ-system actions, we examined, by in situ hybridization analysis, the distribution of preproN/OFQ and N/OFQ receptor mRNAs in the developing and adult mouse central nervous systems (CNS). In most neural regions, preproN/OFQ mRNA was mainly expressed in a small population of middle-sized neurons. These neurons were scattered between large projection-type neurons or within the neuropil, suggestive of interneurons. In some other nuclei (lateral septum, bed nucleus of the stria terminalis, reticular thalamic nucleus, inferior colliculus, and rostral periolivery nucleus), preproN/OFQ mRNA was expressed in a number of large projection-type neurons. By contrast, N/OFQ receptor mRNA was evenly expressed in most neurons of the adult CNS. Considering the inhibitory actions of N/OFQ, the distinct cellular expression pattern of the N/OFQ system suggests that the release of N/OFQ from interneurons may lower neuronal and synaptic activities of neighboring neurons, leading to integration or modulation of local circuits. Furthermore, the cellular expression pattern, distinct from that of the opioid system, may provide a possible molecular/cellular basis for the different in vivo actions of N/OFQ and opioids. In embryonic stages, both preproN/OFQ and N/OFQ receptor mRNAs were highly and widely expressed in the mantle zone, suggesting the possible importance of N/OFQ signaling in CNS development.

show abstract

Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

Cited by 366 publications

References 95 publications

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Further characterization of the ORL₁ receptor‐mediated inhibition of noradrenaline release in the mouse brain in vitro

Distribution of prepro-nociceptin/ orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems

Contact Info

Product

Resources

About

Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

Cited by 366 publications

References 95 publications

[Nphe1]‐Nociceptin (1‐13)‐NH2, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

[Nphe1]‐Nociceptin (1‐13)‐NH2, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Further characterization of the ORL1 receptor‐mediated inhibition of noradrenaline release in the mouse brain in vitro

Distribution of prepro-nociceptin/ orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems

Contact Info

Product

Resources

About

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Further characterization of the ORL₁ receptor‐mediated inhibition of noradrenaline release in the mouse brain in vitro