Nocardiosis: a single-center experience and literature review

Besteiro, Bruno; Coutinho, Daniel; Fragoso, Joana; Figueiredo, Cristóvão; Nunes, Sofia; Azevedo, Carlos; Teixeira, Tiago; Selaru, Aurélia; Abreu, Gabriela; Malheiro, Luís

doi:10.1016/j.bjid.2023.102806

Cited by 4 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…within clinical laboratories [ 4 ]. Notably, instances of nocardiosis have emerged in acquired immunodeficiency syndrome (AIDS) patients, as well as in recipients of solid organ and bone marrow transplants [ 5 ]. Risk factors contributing to the susceptibility to nocardiosis in these patients encompass early graft rejection and intense immunosuppressive regimens [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Disseminated Nocardia farcinica Infection in a Renal Transplant Patient: A Case Report

Mustafa Alhashimi,

Salim,

Iqbal

et al. 2024

Cureus

View full text Add to dashboard Cite

Nocardia farcinica , an aerobic, Gram-positive bacterium belonging to the genus Nocardia , is a challenging opportunistic pathogen, particularly impacting immunocompromised individuals. The prevalence of human disease has witnessed a notable rise over the past two decades, correlating with an expanding population of immunocompromised individuals and advancements in the detection and identification of Nocardia spp. within clinical laboratories. This case is of a 59-year-old male with compromised immunity due to immunosuppressive medication use following a renal transplant who had an array of presentations before confirming a diagnosis of disseminated nocardiosis. The challenges faced in our case provide valuable insights into the complexities associated with diagnosing and managing Nocardia infections in immunocompromised populations, informing future clinical practice and research endeavors.

show abstract

Section: Introductionmentioning

confidence: 99%

Disseminated Nocardia farcinica Infection in a Renal Transplant Patient: A Case Report

Mustafa Alhashimi,

Salim,

Iqbal

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…In addition to the detection of pathogens by culture or next-generation sequencing (NGS) analysis of species, source, and drug sensitivity of pathogens, general laboratory tests also had no specificity and/or sensitivity indicators ( 2 , 3 ). However, Nocardia pneumophila grew very slowly in in vitro medium and was easily covered by other fast-growing bacteria, which made it difficult to be detected ( 4 , 5 ). Nocardia, as an opportunistic anthropozoonotic bacteria pathogen, is resistant to general antibiotics ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: From oral infection to life-threatening pneumonia: clinical considerations in Nocardia infection from a case

Chen,

Wang,

Dong

et al. 2024

Front. Med.

View full text Add to dashboard Cite

Nocardia is an anthropozoonotic bacteria that occurs widely in the natural environment. However, because it is a gram-positive aerobic opportunistic pathogen, it rarely occurs in patients with no prior history of immune function disease. Since the symptoms are nonspecific the diagnosis of Nocardia pneumonia is challenging. Previous studies have not reported that this anthropozoonotic bacteria colonizing the human body could cause severe pneumonia by gingival pain and pharyngeal discomfort. This case report describes a previously healthy 60-year-old female farmer who presented to the doctor with gingival pain and pharyngeal discomfort. She was treated with a dental cleaning and oral metronidazole. The patient rapidly progressed to breathing difficulties. Lung shadow was found by computerized tomography examination. The radiologist diagnosed pulmonary tuberculosis as image-based. Through laboratory examination and culture of pathogenic microorganisms in the sputum and blood of the patient, no obvious positive findings were found. The disease progressed rapidly to tracheal intubation ventilator assisted breathing. Subsequently, the patient underwent alveolar lavatory examination under endotracheal intubation fiberbronchoscopy, and the culture of alveolar lavage fluid indicated Nocardia. According to this result, the patient’s disease was quickly controlled after selecting the targeted drug compound sulfamethoxazole and intravenous meropenem for treatment. In view of the reason for the high misdiagnosis rate due to the low positive rate of Nocardia culture in most cases, the clinical thinking of diagnosis and treatment from oral infection symptoms to fatal pneumonia reported in this case has certain clinical popularization and enlighten significance, not only improved the diagnosis and treatment of rare diseases, but also be reduced medical disputes.

show abstract

Exploring Nocardia’s ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors

Nathar,

Rajmichael,

Jeyaraj Pandian

et al. 2024

Arch Microbiol

View full text Add to dashboard Cite

Nocardiosis: a single-center experience and literature review

Cited by 4 publications

References 42 publications

Disseminated Nocardia farcinica Infection in a Renal Transplant Patient: A Case Report

Disseminated Nocardia farcinica Infection in a Renal Transplant Patient: A Case Report

Case report: From oral infection to life-threatening pneumonia: clinical considerations in Nocardia infection from a case

Exploring Nocardia’s ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors

Contact Info

Product

Resources

About