Nocardial Brain Abscess Cured with Cycloserine and Sulfonamides

Pd, Hoeprich; Brandt, Didier Gabriel; Rh, Parker

doi:10.1097/00000441-196803000-00008

Cited by 40 publications

(8 citation statements)

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“…After manifestation of pulmonary nocardiosis due to inhalation or aspiration, nocardial cells spread to the brain by way of the blood stream in about 2 0 % -3 0 % of patients [5,11,18,26,32,42]. The brain is by far the most common site for nocardial metastasis [42].…”

Section: Discussionmentioning

confidence: 99%

“…Until 1979 all cured cases had undergone neurosurgical procedures [10]. Complete removal was usually followed by prompt recovery [1,2,9,24,26,33,35,36,37,45,60], but occasionally simple aspiration or drainage was also curative [10,24,58]. However, it took 9 and 7 months until resolution of the abscess was demonstrated on followup CT scans in two patients, treated with stereotactic aspiration and antibiotics [25].…”

Section: Discussionmentioning

confidence: 99%

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Nocardial cerebral abscess cured with imipenem/amikacin and enucleation

et al. 1989

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A 72 year old female with cerebral abscess due to Nocardia farcinica is reported. Needle aspiration, antimicrobial therapy using a new combination of imipenem and amikacin, and, finally, surgical excision led to prompt and complete recovery. This is the oldest patient to survive cerebral nocardiosis reported in the literature. This infection, is usually regarded as opportunistic and is encountered with increasing frequency in immunocompromised conditions (organ transplantation, chemotherapy, underlying disabling disorder, acquired immunodeficiency syndrome, etc.). The literature is extensively reviewed for various aspects of this disease including prognostic factors, recent developments in antibiotic therapy (imipenem, amikacin, minocycline etc.) and the essential role of surgery in the treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nocardial cerebral abscess cured with imipenem/amikacin and enucleation

et al. 1989

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“…It is for these reasons that other antimicrobial agents are now used, in conjunction with, or as an alternative to, the sulphonamides. It is by no means clear which additional or alternative drugs should be recommended; cycloserine (Rhoades, Riley & Muchmore, 1961 ;Hoeprich et al 1968), ampicillin (Orfanakis et al 1972)~ septrin (Baikie, MacDonald & Mundy, 1970), and erythromycin and sulphone (Vasarinsh, 1968) have been tried. It can be concluded from the present study that erythromycin, miconazole nitrate and the aminoglycoside antibiotics, especially gentamycin and tobramycin, might be effective in treating Nocardia infections.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Sensitivity of Some Nocardioform Bacteria and its Value as a Criterion for Taxonomy

Goodfellow¹,

Orchard²

1974

Journal of General Microbiology

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“…DISCUSSION Nocardia infections in the untreated patient are usually fatal (8). Most reviewers agree that sulfonamide therapy has reduced mortality from Nocardia infections; however, estimated mortality in treated patients is still sizable, ranging from 50% (9) to 10% (7). For this reason, the addition of a second antimicrobial agent to sulfonamide therapy is often recommended (2,11,14).…”

Section: Methodsmentioning

confidence: 99%

In Vitro Studies of the Combined Effect of Ampicillin and Sulfonamides on Nocardia asteroides and Results of Therapy in Four Patients

Orfanakis

Wilcox

Smith

1972

Antimicrob Agents Chemother

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The minimal inhibiting concentrations (MIC) of ampicillin, trisulfapyrimidines, and various combinations of these drugs were determined for four clinical isolates of Nocardia asteroides on Mueller-Hinton agar. The combination of ampicillin and sulfonamides was found to be synergistic for three of the four isolates when an inoculum of 10 3 to 10 4 organisms per ml was used. (Synergism was defined as occurring when the MIC of each of the drugs in combination was one-quarter or less of the MIC of each drug alone.) All four isolates were inhibited by concentrations of the drugs in combination that were clinically achievable. Combined therapy with ampicillin and sulfonamides was used in four immunologically suppressed renal transplant patients who had pulmonary infection with N. asteroides . Clinical improvement was noted within 2 weeks in all patients, and the pulmonary infiltrates cleared by 6 months in three patients. One patient died from an unrelated illness 10 days after starting therapy. The disease was arrested in two patients who were maintained on full immunosuppressive therapy.

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Nocardial Brain Abscess Cured with Cycloserine and Sulfonamides

Cited by 40 publications

References 0 publications

Nocardial cerebral abscess cured with imipenem/amikacin and enucleation

Nocardial cerebral abscess cured with imipenem/amikacin and enucleation

Antibiotic Sensitivity of Some Nocardioform Bacteria and its Value as a Criterion for Taxonomy

In Vitro Studies of the Combined Effect of Ampicillin and Sulfonamides on Nocardia asteroides and Results of Therapy in Four Patients

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