Nocardia nova Infection of Tibia Tenodesis Implant After Anterior Cruciate Ligament Reconstruction in an Immunocompetent Patient

Young, Patrick; Riga, Andrew

doi:10.5435/jaaosglobal-d-19-00167

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…According to the research data of scholars in the United States, 15 Japan, 16 and France, 17 trimethoprimsulfamethoxazole, linezolid, and amikacin have shown good antibacterial activity against Nocardia. The results of the present study suggest that the use of compound sulphonamide, linezolid, and imipenem also achieves good therapeutic effects.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Rare Bone Infection Caused by Nocardia by 16S rRNA Gene Sequencing

Li¹,

Yu²,

Xiong³

et al. 2023

IDR

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Nocardia is an aerobic actinomycete that causes serious opportunistic infections in immunocompromised individuals. Gene sequencing is the gold standard for pathogenic bacteria diagnosis. This study uses 16S rRNA gene sequencing to diagnose three cases of bone infections caused by Nocardia, including one rare case (N. cyriacigeorgica), and the clinial features, etiological characteristics, treatment, and prognosis of the patients.

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Section: Discussionmentioning

confidence: 99%

Diagnosis of Rare Bone Infection Caused by Nocardia by 16S rRNA Gene Sequencing

Li¹,

Yu²,

Xiong³

et al. 2023

IDR

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“…Device-associated infections become even stickier because of those host-specific, transient, or resident factors ( Table 3 ) [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. The onset of DAI is not predictable, it can onset years after implantation (Cases 1 through 6 in Table 3 ).…”

Section: Clinical Features Of Device-associated Infectionsmentioning

confidence: 99%

“…Methotrexate, a folate antagonist, can affect neutrophil chemotaxis and induce apoptosis of T cells and reactivation of opportunistic pathogens; hence chronic treatment of rheumatoid arthritis with this kind of drug significantly increases the risk of infections around the battery for brain stimulation [ 73 ]. Nocardia nova is a common environmental pathogen and rarely affects immunocompetent hosts; however, this species successfully colonized a tibia implant placed in an immunocompetent patient [ 74 ]. Listeria monocytogenes , a common organism associated with unpasteurized dairy products (e.g., deli meats and unpasteurized cheeses), can induce a periprosthetic joint infection in a patient with a history of diabetes mellitus, asthma, and psoriatic arthritis [ 75 ].…”

Section: Clinical Features Of Device-associated Infectionsmentioning

confidence: 99%

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

Cao

Qiao

Qin

2022

JFB

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The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary “proof of concept” studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the “intended use” of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations.

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Nocardia nova Infection of Tibia Tenodesis Implant After Anterior Cruciate Ligament Reconstruction in an Immunocompetent Patient

Cited by 2 publications

References 15 publications

Diagnosis of Rare Bone Infection Caused by Nocardia by 16S rRNA Gene Sequencing

Diagnosis of Rare Bone Infection Caused by Nocardia by 16S rRNA Gene Sequencing

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

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