Nocardia Keratitis in a Human Immunodeficiency Virus Patient

Abstract

The treatment result for Nocardia keratitis in a human immunodeficiency virus patient was favorable after intensive use of 10% sulfacetamide eyedrops. Nocardia keratitis should be kept in mind as a possible causative organism when antifungal therapy fails in a keratitis case.

The first case of keratitis caused by Nocardia exalbida

“…From the results of disc diffusion method, this species was sensitive to a relatively large number antibiotics compared with previous reports [1,2,[7][8][9]. Although the susceptibility to antibiotics in vitro may not always be reliable for in vivo sensitivity, the response to antibiotics was good in our patient.…”

“…Although the susceptibility to antibiotics in vitro may not always be reliable for in vivo sensitivity, the response to antibiotics was good in our patient. In previous reports, 10% or higher concentration of sulfacetamide eyedrops was used [1,8], but in our case, we used 4% sodium sulfisoxazole solution with other antibiotics, which were effective.…”

“…are a relatively rare cause of infectious keratitis [1,2]. The predisposing factors of Nocardia keratitis are trauma, contact lens wearing, surgery, and immunosuppression [1,2,[7][8][9]. Our patient wore soft contact lenses, and this might have contributed to this infection.…”

Ocular Bacterial Flora in HIV-Positive Patients and Their Sensitivity to Gentamicin

“…1 It has been reported that choroidal neovascularization (CNV) only infrequently accompanies dominant drusen, but when it does, it can lead to severe visual impairment. 2, 3 We report a Japanese patient with dominant drusen accompanied by CNV, which was successfully treated with photocoagulation.…”

“…However, the natural defense is a combination of innate immunity and specific acquired immunity. 1 Acquired immunodeficiency syndrome (AIDS) is caused by infection with the human immunodeficiency virus (HIV). This retrovirus infects and destroys T-helper cells, resulting in a profound deficiency of natural immunity.…”