Nocardia beijingensis pulmonary infection successfully treated with intravenous beta-lactam antibiotics and oral minocycline

Ogawa, Taku; Kasahara, Kei; Yonekawa, Shinsuke; Nakagawa, Chiyo; Maeda, Koichi; Konishi, Mitsuru; Mikasa, Keiichi; Kikuchi, Ken

doi:10.1007/s10156-011-0233-2

Cited by 11 publications

(7 citation statements)

References 21 publications

(37 reference statements)

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“…Regimens with quinolones have been described in several case reports, especially in patients with CNS nocardiosis, due to their excellent cerebrospinal fluid penetration and low toxicity (20,21). Minocycline is another potentially useful drug (22,23) whilst linezolid has been indicated to be an effective alternative for the treatment of nocardiosis in certain studies (5,10,23–26). Previous clinical experience obtained from the study site has revealed that linezolid has a marked effectiveness in treating Nocardia infection (24,26).…”

Section: Discussionmentioning

confidence: 99%

Clinical findings of 40 patients with nocardiosis: A retrospective analysis in a tertiary hospital

Yang

Wei

et al. 2014

Experimental and Therapeutic Medicine

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To the best of our knowledge, no Chinese case studies concerning Nocardia infection have been published to date. Therefore, the present study aimed to retrospectively evaluate the risk factors, clinical features, imaging results, laboratory abnormalities, treatments and outcomes of nocardiosis in a Chinese tertiary hospital. Data collected from patients with laboratory-confirmed nocardiosis were retrospectively analyzed. A total of 40 patients who had a positive culture of Nocardia were included. The median time between the onset of symptoms and diagnosis was 42 days. Underlying diseases were identified in 72.5% of the patients of which diabetes was the most common (32.5%). The most important risk factor was corticosteroid administration. Fever and cough were common clinical symptoms. The pleuropulmonary (85%) were the most frequently involved sites and the disseminated disease rate was 30.0%. Frequent chest computed tomography scans revealed the presence of airspace opacities, nodules and masses, in addition to cavitary lesions that were particularly common among the study group. Brain images revealed lesions associated with abscesses. The majority of the patients (71.1%) were treated with trimethoprim sulfamethoxazole alone or in combination with other drugs. The in-hospital mortality rate was 15.0%. Disseminated disease, immunocompromised patients, an older age, brain involvement and concomitant infections were associated with a poor prognosis. Nocardiosis is an uncommon but emerging disease. The present study reports the first case series on nocardiosis from China and provides important information on the clinical features and risk factors of nocardiosis. Early recognition of the disease and the initiation of appropriate treatment are essential for a good prognosis.

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Section: Discussionmentioning

confidence: 99%

Clinical findings of 40 patients with nocardiosis: A retrospective analysis in a tertiary hospital

Yang

Wei

et al. 2014

Experimental and Therapeutic Medicine

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“…Clinical success has been reported with minocycline at 200 mg/day in monotherapy or in association with trimethoprim-sulfamethoxazole for treatment of cutaneous nocardiosis (18,19). It was also efficient as a maintenance treatment after an initial 3 to 5 weeks of intravenous treatment in pulmonary nocardiosis (20,21). Regarding nocardial CNS infection, Wren et al reported a successful treatment with minocycline at 400 mg/day.…”

Section: Case Reportmentioning

confidence: 99%

First Case of Cerebral Abscess Due to a Novel Nocardia Species in an Immunocompromised Patient

et al. 2013

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“… 2 isolated a novel species, Nocardia beijingensis , from soil in China, whose infections to human beings have been observed in eastern Asia and Spain 3–5 . In Japan, three cases of pulmonary nocardiosis caused by N. beijingensis have been reported, however, there has been no paper describing its infection into the skin 6–8 . Here, we report a case of primary cutaneous nocardiosis by N. beijingensis during chemotherapy for an advanced prostate cancer, and review the four Japanese cases.…”

Section: Reported Japanese Cases Of Nocardiosis Caused By Nocardia Bmentioning

confidence: 97%

“…In Table 1, we summarize the clinical characteristics of four Japanese cases of nocardiosis caused by N. beijingensis 6–8 . The mean age at diagnosis was 64 years, ranging 48–79 years, which was no different from that of infections by other Nocardia species 1 .…”

Section: Reported Japanese Cases Of Nocardiosis Caused By Nocardia Bmentioning

confidence: 99%

Primary cutaneous nocardiosis caused by Nocardia beijingensis in an immunocompromised patient with chemotherapy for advanced prostate cancer

Ohmori¹,

Miwa²,

Yaguchi³

et al. 2011

The Journal of Dermatology

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Nocardia beijingensis pulmonary infection successfully treated with intravenous beta-lactam antibiotics and oral minocycline

Cited by 11 publications

References 21 publications

Clinical findings of 40 patients with nocardiosis: A retrospective analysis in a tertiary hospital

Clinical findings of 40 patients with nocardiosis: A retrospective analysis in a tertiary hospital

First Case of Cerebral Abscess Due to a Novel Nocardia Species in an Immunocompromised Patient

Primary cutaneous nocardiosis caused by Nocardia beijingensis in an immunocompromised patient with chemotherapy for advanced prostate cancer

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