Nobori Stent Shows Less Vascular Inflammation and Early Recovery of Endothelial Function Compared With Cypher Stent

Pendyala, Lakshmana; Matsumoto, Daisuke; Shinke, Toshiro; Iwasaki, Takuya; Sugimoto, Ryota; Hou, Dongming; Chen, Jack P.; Singh, Jyoti; King, Spencer B.; Chronos, Nicolas; Li, Jinsheng

doi:10.1016/j.jcin.2011.11.013

Cited by 57 publications

(32 citation statements)

References 19 publications

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“…38 Similarly, Pendyala et al revealed a significantly lowered inflammatory response in the stented segments and rapid recovery of endothelial function in persistent segments in the BES group compared with the Cypher group. 39 We speculate that a lower inflammatory response and rapid recovery of endothelial function after BES implantation might protect against atherogenic change. Larger and longer follow-up studies are warranted to validate our hypothesis.…”

Section: Atherosclerotic Changes In the Neointima After Bes Implantationmentioning

confidence: 87%

Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation

Konishi

Shinke

Otake

et al. 2014

Circ J

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Section: Atherosclerotic Changes In the Neointima After Bes Implantationmentioning

confidence: 87%

Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation

Konishi

Shinke

Otake

et al. 2014

Circ J

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“…We had already reported that BES revealed significantly lower inflammatory response as compared with SES [16]. Hagiwara reported that inflammatory score and injury score in BES were comparable to even bare metal stent at 30 days in histological analysis [17].…”

Section: Accepted Manuscriptmentioning

confidence: 89%

A comparison of drug eluting stent biocompatibility between third generation NOBORI biolimus A9-eluting stent and second generation XIENCE V everolimus-eluting stent in a porcine coronary artery model

Sumida

Gogas

Nagai

et al. 2015

Cardiovascular Revascularization Medicine

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“…The polymer used in DES facilitates the controlled elution of antiproliferative drugs over a period of time. However, once drug elution has been completed, durable polymers have been implicated as potential triggers for late and very late stent thrombosis [19,20]. Biodegradable polymers, as opposed to durable polymers, can be completely metabolized, potentially reducing the risk of late complications such as stent uncovering, malapposition, and endothelial dysfunction [19].…”

Section: Discussionmentioning

confidence: 99%

Stent Thrombosis with Biodegradable Polymer Drug-Eluting Stents versus Durable Polymer Sirolimus-Eluting Stents: An Update Meta-Analysis

Zhu¹,

Lv²,

Wang³

2015

Cardiology

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Objective: Durable polymer sirolimus-eluting stents (DP-SES) are associated with a low risk of stent thrombosis; biodegradable polymer drug-eluting stents (BP-DES) were designed to reduce these risks. However, their benefits are still variable. Method: We undertook a meta-analysis of randomized trials identified by systematic searches of Medline, Embase, and the Cochrane Database. Results: Eleven studies (9,676 patients) with a mean follow-up of 22.6 months were included. Overall, compared with DP-SES, BP-DES significantly lowered the rate of definite or probable stent thrombosis (RR, 0.73; 95% CI, 0.55-0.97; p = 0.03; I² = 0.0%) due to a decreased risk of very late stent thrombosis (RR, 0.26; 95% CI, 0.11-0.63; p = 0.00; I² = 0.0%). However, BP-DES were associated with a comparable rate of early and late stent thrombosis. Meanwhile, BP-DES were associated with a broadly equivalent risk of target vessel revascularization (RR, 0.90; 95% CI, 0.78-1.03; p = 0.13; I² = 0.0%), cardiac death (RR, 0.89; 95% CI, 0.72-1.09; p = 0.24; I² = 0.0%), myocardial infarction (RR, 1.03; 95% CI, 0.84-1.26; p = 0.79; I² = 0.0%), and major adverse cardiac events (MACE; RR, 0.91; 95% CI, 0.83-1.0; p = 0.08; I² = 0.0%). Furthermore, angiographic data showed that in-stent and in-segment late luminal loss were similar between the two groups. Conclusions: Compared with DP-SES, BP-DES were associated with a lower rate of very late stent thrombosis and an equivalent risk of MACE. Larger randomized studies are needed to confirm this finding.

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Nobori Stent Shows Less Vascular Inflammation and Early Recovery of Endothelial Function Compared With Cypher Stent

Abstract: Our data show significantly lower inflammatory response in the stented segments, and rapid recovery of endothelial function of peristent segments in the Nobori group compared with Cypher DES group at 1 month in porcine coronary artery model.

Cited by 57 publications

References 19 publications

Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation

Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation

A comparison of drug eluting stent biocompatibility between third generation NOBORI biolimus A9-eluting stent and second generation XIENCE V everolimus-eluting stent in a porcine coronary artery model

Stent Thrombosis with Biodegradable Polymer Drug-Eluting Stents versus Durable Polymer Sirolimus-Eluting Stents: An Update Meta-Analysis

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