Noble Metal Nanoparticle Platform

Chen, Jingyi

doi:10.1016/b978-0-12-407722-5.00018-9

Cited by 8 publications

(4 citation statements)

References 101 publications

(112 reference statements)

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“…"Theranostics" is a portmanteau of therapeutics and diagnostics; theranostic materials possess both of these capabilities [105]. Most studies have concentrated on oncological applications which has been covered in the book chapter by Chen [106]. In this context, nononcological applications of plasmonic nanostructures are the primary focus.…”

Section: Biomedical and Sensing Applicationsmentioning

confidence: 99%

Plasmonic Nanostructures for Biomedical and Sensing Applications

Jenkins

Muldoon

Chen

2014

Metallic Nanostructures

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Noble metal nanostructures are appealing for therapeutic, diagnostics, and sensing applications because of their unique optical properties and biocompatibility. The collective oscillation of electrons in a metal nanostructure resonates with particular wavelengths of light, generating the localized surface plasmon resonance (LSPR). The LSPR results in absorption and scattering of incoming photons. Absorption leads to photothermal generation of heat, photoluminescence, and quenching of fluorophores in close proximity. Scattering results in reflected photons and its amplification of the local electromagnetic field can enhance fluorescence, phosphorescence, and Raman scattering. These optical properties make plasmonic nanostructures ideal candidates for theranostic applications including light-induced thermal therapy, drug/gene delivery, and biomedical imaging. The use of plasmonic nanostructures for ex vivo detection of chemicals and biomolecules are also discussed in this chapter.

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Section: Biomedical and Sensing Applicationsmentioning

confidence: 99%

Plasmonic Nanostructures for Biomedical and Sensing Applications

Jenkins

Muldoon

Chen

2014

Metallic Nanostructures

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“…The bottomup synthesis of metallic nanoparticles from the corresponding metallic salts requires a reducing agent to convert the salt ion (m n+ ) to the atomic form (m o ) (miranda et al 2016). The reducing role played by cysteine and lysine residues for reducing the metal ions to the atomic form to produce the nanoclusters is well known (Xia et al 2009, Chen 2014, Spicer and Davis 2014, Siriwardana et al 2015. Proteins and peptides have threedimensional structures that create specific microenvironments for the nucleation process and nanoparticle growth.…”

Section: Characteristic Of Protein and Peptide Structures Useful For The Synthesis And Stabilization Of Nanostructuresmentioning

confidence: 99%

Proteins and Peptides at the Interfaces of Nanostructures

Brito

Belleti

Menezes

et al. 2019

An. Acad. Bras. Ciênc.

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The present review focuses on the proteins and peptides at the interfaces of nanostructured metals and semiconductors as a result of their use in synthesis in-situ and functionalization of nanostructures. We start the review with an introduction about the peculiar properties of nanostructured materials and their applications. In the following, the chemical and structural properties of peptides and proteins that allow their use as reducing, stabilizing, and functionalization agents are discussed. Proteins and peptides have not only the chemical groups for the metal ion reducing but also provide templates for directing the crystalline growing of nanostructures to the desired shapes and sizes. Proteins and peptides are also used mainly for the stabilization and functionalization of a diversity of nanostructured materials providing properties such as biocompatibility, plasmon-enhanced catalysis, sensing, micro/nanomotors, spin filters, and others. Nanostructured materials of metal oxides have mainly been functionalized with proteins and peptides to gain specific properties such as light harvesting and spin filters. Herein, we described the synthesis and functionalization of some types of nanostructured materials by using peptides and proteins. In the last part of the review, it is discussed the perspectives and challenges for the use of proteins and peptides in Nanotechnology.

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“…Photothermal agents (e.g., Au, Ag) that absorb NIR sources and convert photon energy into heat can be used in PTT to destroy cancer cells. − AuNRs are regarded as an attractive photothermal agent, considering they are easily synthesizable and have unique optical properties with compact size . According to recent studies, AuNRs can ablate tumors efficiently due to the photothermal effect under NIR radiation. − The tunable surface plasmon resonance (SPR) band of AuNRs allows change of absorbance of certain wavelengths that are necessary for cancer therapy and biological imaging.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanorod/Reduced Graphene Oxide Composite Nanocarriers for Near-Infrared-Induced Cancer Therapy and Photoacoustic Imaging

Lee

Kim

2021

ACS Appl. Nano Mater.

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Recently, various multifunctional nanomaterials have attracted attention as promising theranostic systems for effective diagnosis, bioimaging, and therapy of cancer. In this study, we designed multifunctional nanocarriers based on partially reduced graphene oxide (PrGO) and gold nanorods (AuNRs) for near-infrared (NIR)-induced synergistic photodynamic therapy (PDT)/photothermal therapy (PTT) and photoacoustic (PA) imaging. We synthesized AuNR/PrGO composite nanocarriers that combine photosensitizers (PSs) and tumor targeting ligands. The AuNR/PrGO composite nanocarriers (AuNR/FP-PrGO-Ce6) showed a unimodal size distribution of approximately 386.9 nm and excellent stability in aqueous solution. They also exhibited significantly improved generation kinetics of singlet oxygen and great photothermal conversion efficiency. Furthermore, the sample AuNR/FP-PrGO-Ce6 showed a PA signal intensity that was 2.4 times stronger than that of bare AuNR under the same conditions. Our measurements by confocal microscope and flow cytometry indicate that AuNR/FP-PrGO-Ce6 nanocarriers were internalized successfully in MCF7 cells (a cell line with folate receptor overexpression) due to the active targeting property of the FA ligand. Compared to free PS, the AuNR/FP-PrGO-Ce6 nanocarriers showed significant synergistic effects on PDT/PTT, destroying 95% of cancer cells by irradiating simultaneously with 670 and 880 nm lasers for 5 min. These multifunctional AuNR/PrGO composite nanocarriers are a promising approach for applications in anticancer theranostics.

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Noble Metal Nanoparticle Platform

Cited by 8 publications

References 101 publications

Plasmonic Nanostructures for Biomedical and Sensing Applications

Plasmonic Nanostructures for Biomedical and Sensing Applications

Proteins and Peptides at the Interfaces of Nanostructures

Gold Nanorod/Reduced Graphene Oxide Composite Nanocarriers for Near-Infrared-Induced Cancer Therapy and Photoacoustic Imaging

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