Noble Metal Complexes in Cancer Chemotherapy

Remarks in Successful Cellular Investigations for Fighting Breast Cancer Using Novel Synthetic Compounds

“…Rosenberg confusion about the effects of electric field on the cells resulted in cisplatin identification and later use as a very important and most used anticancer drug in many different kinds of malignancies including the breast cancer (Rosenberg et al, 1969). Cells in Rosenberg set up did not die, rather changed shape and remained alive for a long time (Rosenberg, 1985(Rosenberg, , 1977. Cisplatin, like many other anti-mitotic agents, does not kill cells right after exposure.…”

Platinum complexes inhibit ATP‐driven basic dye uptake in lysosomes from rat liver

“…The possibility that the hydrolysis product of platinum complexes might be involved in the observed inhibition, as found in studies on mitochondrial ATPase [35] deserved some consideration, but it appears unlikely in the C1-medium used in these studies [36].…”

Effect of Desferrioxamine on Cisplatin-induced Nephrotoxicity in Normal Rats

“…It shows a broad spectrum of antitumor activities in ani mal tumor systems [1,2] and in certain hu man cancers [3,4], The optimal use of cispla tin is prevented by a dose-limiting nephrotox icity [5], The exact mechanism of this nephro toxicity is not yet known. However, lipid per oxidation or free radicals generated by cispla tin have been suggested to be responsible for the nephrotoxicity [6,7], The liberation of free radicals can be completely inhibited by the iron chelator desferrioxamine [8], Al-Harbi et al [9] and Osman et al [10] have reported that desferrioxamine can protect against doxorubicin-induced cardiac and he matological damage in normal rats and mice via inhibition of lipid peroxidation.…”