Noble gas solubility measurement in liquid scintillator solvents

Cejnar, František; Wilhelmová, L.; Vrzala, Pavel

doi:10.1016/0020-708x(77)90075-8

Cited by 4 publications

References 4 publications

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Transition metal mediated synthesis using [¹¹C]CO at low pressure – a simplified method for ¹¹C‐carbonylation

Eriksson

Hoek

Windhorst

2012

Labelled Comp Radiopharmac

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Transition metal mediated carbonylation with [11C]CO has proven a useful method to label a wide array of compounds in the carbonyl position. However, the general use in radiopharmaceutical synthesis has been hampered by the low solubility of carbon monoxide in most solvents and the resulting challenge to confine [11C]CO in low volume reaction vessels. This paper introduces a method that utilises xenon to transfer pre‐concentrated [11C]CO to a sealed disposable glass vial containing carbonylation reagents. The high solubility of xenon in the organic solvent made it possible to confine the [11C]CO without utilising a pressure autoclave or chemical trapping additives. The utility of the method in 11C‐carbonylation was investigated by conducting three model reactions, where [11C‐carbonyl]N‐benzylbenzamide, [11C‐carbonyl]triclocarban and [11C‐carbonyl]methyl nicotinate were afforded in decay corrected radiochemical yields of 71 ± 6%, 42 ± 15% and 29 ± 10%, respectively. These promising results and the straight forward technical implementation suggest that 11C‐cabonylation can become a viable mean to provide labelled carbonyl functionalities in routine radiopharmaceutical synthesis. Compounds labelled with short lived positron emitters are used in Positron Emission Tomography, a molecular imaging technology with applications in clinical diagnostics, clinical research and basic biomedical research.

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Transition metal mediated synthesis using [¹¹C]CO at low pressure – a simplified method for ¹¹C‐carbonylation

Eriksson

Hoek

Windhorst

2012

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

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Measurement of krypton-85 in the atmosphere with a portable apparatus

Okai

Takashima

Shiraishi³

et al. 1984

Journal of Radioanalytical and Nuclear Chemistry, Articles

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Determination of radionuclide two-phase distribution by well-type NaI(Tl) detectors

Cejnar¹,

Wilhelmová²,

I³

1981

The International Journal of Applied Radiation and Isotopes

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Noble gas solubility measurement in liquid scintillator solvents

Cited by 4 publications

References 4 publications

Transition metal mediated synthesis using [¹¹C]CO at low pressure – a simplified method for ¹¹C‐carbonylation

Transition metal mediated synthesis using [¹¹C]CO at low pressure – a simplified method for ¹¹C‐carbonylation

Measurement of krypton-85 in the atmosphere with a portable apparatus

Determination of radionuclide two-phase distribution by well-type NaI(Tl) detectors

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Noble gas solubility measurement in liquid scintillator solvents

Cited by 4 publications

References 4 publications

Transition metal mediated synthesis using [11C]CO at low pressure – a simplified method for 11C‐carbonylation

Transition metal mediated synthesis using [11C]CO at low pressure – a simplified method for 11C‐carbonylation

Measurement of krypton-85 in the atmosphere with a portable apparatus

Determination of radionuclide two-phase distribution by well-type NaI(Tl) detectors

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Transition metal mediated synthesis using [¹¹C]CO at low pressure – a simplified method for ¹¹C‐carbonylation

Transition metal mediated synthesis using [¹¹C]CO at low pressure – a simplified method for ¹¹C‐carbonylation