Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

Yabuki, Yasushi; Ohizumi, Yasushi; Yokosuka, Akihito; Mimaki, Yoshihiro; Fukunaga, Kohji

doi:10.1016/j.neuroscience.2013.11.051

Cited by 101 publications

(67 citation statements)

References 52 publications

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“…Nobiletin stimulates the cAMP-dependent protein kinase and extracellular signal-regulated kinase signaling pathways in PC12 cells and cultured hippocampus neurons (7,8). In in vivo experiments, nobiletin has been shown to improve memory deficits in an animal model of Alzheimer's disease (12) as well as ischemia-induced memory deficits (18), and to improve motor and cognitive deficits in an animal model of MPTP-induced Parkinson disease (17). 3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF) is a PMF structurally related to nobiletin (4,9).…”

Section: Introductionmentioning

confidence: 99%

3,5,6,7,8,3’,4’-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of mice

et al. 2016

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In our previous studies, we reported anti-inflammatory functions of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), which is a polymethoxyflavone rich in various citrus fruits. Here, we investigated the immunomodulatory function of HMF in mice. HMF administration (50 mg/kg, i.p., 2 times/ week) tended to reduce the production of antigen-specific IgE induced by ovalbumin in combination with aluminum hydroxide gel. Fluorescence-activated cell sorting analysis revealed the reduction of interleukin-4 +

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Section: Introductionmentioning

confidence: 99%

3,5,6,7,8,3’,4’-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of mice

et al. 2016

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“…It is well known that MPTP-induction to non-human primates and mice develop cognitive deficits [12,13]. Therefore, testing the behavioral function provides a sensitive evaluation of the CCY's ability to provide neuroprotection.…”

Section: Discussionmentioning

confidence: 99%

“…MPTP-induction has been well reported for the development of cognitive and behavioral deficits in both non-human primates and mice models [12,13]. Therefore, MPTP-induced neurotoxicity in mice is considered as the most useful functional model of Parkinsonism [13].…”

Section: Cuminum Cyminum Linn (Cmentioning

confidence: 99%

Cuminum cyminum Linn (Apiaceae) extract attenuates MPTP-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease

Kim¹,

Kopalli²,

Koppula³

2016

Trop. J. Pharm Res

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Purpose: To evaluate the protective effects of Cuminum cyminum Linn (Apiaceae, CCY) against 1-methyl-4 phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced oxidative stress and behavioral impairments in mouse model of Parkinson's disease (PD). Methods: MPTP-intoxicated mice model of PD was used for evaluating the effect of CCY extract on behavioral deficits through rota rod, passive avoidance and open field tasks. The effect of CCY extract on oxidative stress levels were assessed by estimating enzyme status, including superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation(LPO) in brain tissues

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“…Our screening of natural resources lead to the finding that nobiletin, a citrus flavonoid, activates the CREdependent transcription in PC12D cells, a rat pheochromocytoma cell line [3]. Our next studies proved that nobiletin improves the memory deterioration in beta-amyloid infused AD model rats [4], bulbectomy-induced cholinergic neurodegenerative mice [5], a transgenic mouse model of AD [6], and Parkinson disease model mice [7]. Using the same strategy, we found that honeybee RJ stimulates the CRE-dependent transcription in PC12D cells [8].…”

mentioning

confidence: 81%

Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12

Takito

Ota

Oba

et al. 2017

PMIO

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!Prevention and treatment of Alzheimerʼs disease are urgent problems for elderly people in developed countries. To seek useful compounds that treat, delay the onset, or prevent the development of Alzheimerʼs disease, we screened natural resources using the cyclic AMP response element-dependent transcription in the PC12 cell line. We previously found that honey bee royal jelly stimulates the cyclic AMP response element-dependent transcription activity in PC12 cells. Here, we report that R-limonene, a monoterpene, enhanced the royal jelly-induced cyclic AMP response element-dependent transcription activity, whereas R-limonene showed no effect in absence of royal jelly. The enhancement was inhibited by ZM241385, an antagonist for adenosine A 2 A receptor. R-limonene also enhanced the cyclic AMP response element-dependent transcription activity activated by adenosine and AMP. Thus, R-limonene represents a novel type of modulator that enhances the CRE-dependent transcription via adenosine A 2 A receptor pathway. To find a substance that potentiates the antidementia activity of RJ, we screened extracts derived from herbal plants. Preliminary screening identified limonene as a candidate for the activator of the RJ-induced stimulation of CRE-dependent transcription in PC12 cells. To confirm this finding, we tested commercially available limonenes for the CRE-dependent transcription induced by RJ in PC12 cells. As shown in l " Fig. 1 A, R-limonene dose-dependently enhanced the CRE-dependent transcription activity induced by 10 µg/mL RJ. Interestingly, R-limonene had no effect on the CRE-dependent transcription activity in the absence of RJ. Rlimonene was effective on both low and high concentrations of RJ (l " Fig. 1 B). We next examined the effect of R-limonene on RJ along the timecourse of its stimulation of CRE-dependent transcription (l " Fig. 2). RJ at 10 µg/mL significantly increased the CRE-dependent transcription activity 1-5 h after administration. The activating effect of RJ diminished at 24 and 48 h after administration. The addition of 100 µM R-limonene to RJ significantly enhanced the CRE-dependent transcription activity induced by RJ from 1 to 24 h. Again, R-limonene alone had no effect on the CRE-dependent transcription activity at all time points examined. We next tested the effect of several analogues of R-limonene on the CRE-dependent transcription induced by RJ (l " Fig. 3). (S)-(−)-limonene and (4R)-limonene oxide enhanced the RJ-induced CRE-dependent transcription comparable to the level of R-limonene. (4 S)-limonene oxide significantly increased the CRE-dependent transcription induced by RJ, but the potency of the limonene oxide was weaker than that of R-limonene. Interestingly, all these limonene analogues had no effect on the CRE-dependent * These authors contributed equally to this work. Letter THIEME Key words

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Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

Cited by 101 publications

References 52 publications

<b>3,5,6,7,8,3’,4’-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of </b><b>mice </b>

<b>3,5,6,7,8,3’,4’-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of </b><b>mice </b>

<i>Cuminum cyminum </i>Linn (Apiaceae) extract attenuates MPTP-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease

Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12

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