Nobiletin protects enteric nerves and ameliorates disordered bowel motility in diet-induced obese mice via increasing Trem2 expression

Pang, Yueshan; Ni, Yang; Zheng, Yali; Zhang, Lu; He, Yan; Ding, Weijun

doi:10.1016/j.bbrc.2022.10.008

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…There are many studies of nobiletin in the CNS, and the effect of nobiletin on the peripheral nervous system has gradually attracted attention in recent years [ 15 , 42 , 46 , 65 , 70 ], especially in the ENS [ 46 ]. Many risk factors cause ENS damage.…”

Section: Discussionmentioning

confidence: 99%

“…After demethylation, nobiletin has a stronger solubility and biological activity [ 14 ]. A study has shown that nobiletin protects against HFD-induced ENS damage [ 46 ]. However, further studies are necessary to deeply elucidate the mechanism of nobiletin in the ENS.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study also suggested that nobiletin (100 or 200 mg/kg, p.o.) inhibited HFD-induced colon inflammation and improved colon motor function by increasing Trem2 expression [ 46 ]. The ENS has been a focus of research in recent years.…”

Section: Effect and Mechanisms Of Nobiletin In The Peripheral Nervous...mentioning

confidence: 99%

“…Citrus peel, as a byproduct of fruit and a traditional Chinese herb, has been widely used since ancient times. Nobiletin, a natural extract of citrus peel, has been widely studied in nervous system diseases, such as Alzheimer’s disease (AD) [ 12 ], depression [ 32 ], stroke [ 60 , 62 ], amyotrophic lateral sclerosis [ 18 ], and even enteric nervous system disease [ 16 , 46 ]. However, its specific molecular mechanisms are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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A review on recent advances on nobiletin in central and peripheral nervous system diseases

Pang,

Xiong,

et al. 2023

Eur J Med Res

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In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited. Nobiletin, as a compound with high fat solubility, high bioavailability and low toxicity, has been extensively studied. Accumulating scientific evidence has shown that nobiletin has a variety of biological functions in the nervous system, such as inhibiting the expression of inflammatory factors, reducing the neurotoxic response, improving the antioxidant capacity, promoting the survival of nerve cells, promoting axon growth, reducing blood‒brain barrier permeability, reducing brain oedema, promoting cAMP response element binding protein expression, improving memory, and promoting mild depolarization of nerve cell mitochondria to improve antioxidative stress capacity. Accumulating studies have shown that nobiletin also protects enteric nervous system, spinal cord and sciatic nerve. To explore the new therapeutic potential of nobiletin in the nervous system, recent and relevant research progress is reviewed in this article. This will provide a new research idea for nobiletin in the nervous system.

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