Nobiletin, a polymethoxy flavonoid, exerts anti-allergic effect by suppressing activation of phosphoinositide 3-kinase

Onishi, Sayo; Nishi, Kosuke; Yasunaga, Sho; Muranaka, Ayako; Maeyama, Kazutaka; Kadota, Ayumu; Sugahara, Takuya

doi:10.1016/j.jff.2013.12.005

Cited by 29 publications

(12 citation statements)

References 34 publications

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“…Phenolic compounds, one of the most important secondary metabolites, are greatly distributed in all parts of higher plants [ 1 ]. More recently, phenolic compounds have attracted extensive attention due to their numerous biological activities, such as antioxidant, antibacterial, antitumor, anti-diabetic and anti-inflammatory activities [ 2 , 3 , 4 , 5 , 6 ]. In recent years, natural antioxidant phenolic compounds obtained from edible byproducts or residual sources have also become interesting because they could be recycled and developed into new medicinal resources [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Ultrasonic-Assisted Enzymatic Extraction Conditions for Improving Total Phenolic Content, Antioxidant and Antitumor Activities In Vitro from Trapa quadrispinosa Roxb. Residues

et al. 2017

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Stems are the important residues of Trapa quadrispinosa Roxb., which are abundant in phenolic compounds. Ultrasonic-assisted enzymatic extraction (UAEE) is confirmed as a novel extraction technology with main advantages of enhancing extraction yield and physiological activities of the extracts from various plants. In this study, UAEE was applied to obtain the highest yield of phenolic content, strongest antioxidant, and antitumor activities and to optimize the extraction conditions using response surface methodology (RSM). The extracts from the stems of T. quadrispinosa were characterized by determination of their antioxidant activities through 2,2-azinobis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS), 1,1-Diphenyl-2-picrylhydrazxyl (DPPH) radical scavenging, total antioxidant capacity (TAC), ferric reducing antioxidant capacity (FRAC) methods and of their antitumor activity by MTT method. The selected key independent variables were cellulase concentration (X1: 1.5%–2.5%), extraction time (X2: 20–30 min) and extraction temperature (X3: 40–60 °C). The optimal extraction conditions for total phenolic content (TPC) value of the extracts were determined as 1.74% cellulase concentration, 25.5 min ultrasonic extraction time and 49.0 °C ultrasonic temperature. Under these conditions, the highest TPC value of 53.6 ± 2.2 mg Gallic acid equivalent (GAE)/g dry weight (DW) was obtained, which agreed well with the predicted value (52.596 mg GAE/g·DW. Furthermore, the extracts obtained from UAEE presented highest antioxidant activities through ABTS, DPPH, TAC and FRAC methods were of 1.54 ± 0.09 mmol Trolox equivalent (TE)/g·DW; 1.45 ± 0.07 mmol·TE/g·DW; 45.2 ± 2.2 mg·GAE/g·DW; 50.4 ± 2.6 μmol FeSO4 equivalent/g·DW and lowest IC50 values of 160.4 ± 11.6 μg/mL, 126.1 ± 10.8 μg/mL, and 178.3 ± 13.1 μg/mL against Hela, HepG-2 and U251 tumor cells, respectively. The results indicated that the UAEE was an efficient alternative to improve extraction yield and enhance the antioxidant and antitumor activities of the extracts. The phenolic extracts from the stems of T. quadrispinosa had significant antioxidant and antitumor activities, which could be used as a source of potential antioxidant and antitumor agents.

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Section: Introductionmentioning

confidence: 99%

Optimization of Ultrasonic-Assisted Enzymatic Extraction Conditions for Improving Total Phenolic Content, Antioxidant and Antitumor Activities In Vitro from Trapa quadrispinosa Roxb. Residues

et al. 2017

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“…In two of our earlier studies, we demonstrated that both nobiletin and b-LG reduced allergic responses. 22,23 A combi- Effect of mandarin orange yogurt and control yogurt on clinical scores after CAC in experiment 2. The redness, chemosis, and itching scores were significantly lower after ingestion of the mandarin orange yogurt.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mandarin Orange Yogurt on Allergic Conjunctivitis Induced by Conjunctival Allergen Challenge

Hara

Shiraishi

Sakane

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…However, it also showed antiparasitic effect,22 anti-infective activity against some strains of Staphylococcus , Pseudomonas , and Escherichia coli 23,24 and antioxidant and anti-inflammatory properties 18,25,26. The presence of nobiletin, a citrus flavonoid that is associated with the suppression of mast cell degranulation,27 could explain its effects 8…”

Section: Discussionmentioning

confidence: 99%

Antiallergic effect of the atomized extract of rhizome of Curcuma longa, flowers of Cordia lutea and leaves of Annona muricata

Arroyo-Acevedo¹,

Franco-Quino

Ruiz-Ramírez

et al. 2016

TCRM

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IntroductionAllergies are a problem that greatly affects the population, and hence the use of antiallergic medications is fairly widespread. However, these drugs have many adverse effects. The use of medicinal plants could be an option, but they need to be evaluated.ObjectiveThis study was designed to evaluate the antiallergic effect of the atomized extract of rhizome of Curcuma longa, flowers of Cordia lutea, and leaves of Annona muricata.Materials and methodsTwenty-four New Zealand white albino rabbits were randomized into 2 groups. Group A received the atomized extract diluted in physiological saline (APS) and group B received it diluted in Freund’s adjuvant (FA). Then, the back of each rabbit was divided into 4 quadrants. The A-I quadrant received only physiological saline. The A-I quadrants of each rabbit conformed the PS group. The following 3 quadrants received the APS in 10 μg/mL, 100 μg/mL, and 1,000 μg/mL, respectively. The B-I quadrant received only FA. The B-I quadrants of each rabbit conformed the FA group. The following 3 quadrants received the AFA in 10 μg/mL, 100 μg/mL, and 1,000 μg/mL, respectively. The occurrence of erythema and edema was recorded according to the Draize scoring system and the primary irritation index. After 72 hours, biopsies were performed.ResultsThe AFA group presented significantly less erythema and edema compared to the FA group (P<0.05). The histopathologic evaluation at 72 hours showed normal characteristics in the APS group.ConclusionConsidering the clinical and histopathological signs, we conclude that the administration of the atomized extract of rhizome of C. longa, flowers of C. lutea, and leaves of A. muricata lacks antigenic effect but could have an antiallergenic effect in a model of dermal irritation in rabbits.

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Nobiletin, a polymethoxy flavonoid, exerts anti-allergic effect by suppressing activation of phosphoinositide 3-kinase

Cited by 29 publications

References 34 publications

Optimization of Ultrasonic-Assisted Enzymatic Extraction Conditions for Improving Total Phenolic Content, Antioxidant and Antitumor Activities In Vitro from Trapa quadrispinosa Roxb. Residues

Optimization of Ultrasonic-Assisted Enzymatic Extraction Conditions for Improving Total Phenolic Content, Antioxidant and Antitumor Activities In Vitro from Trapa quadrispinosa Roxb. Residues

Effect of Mandarin Orange Yogurt on Allergic Conjunctivitis Induced by Conjunctival Allergen Challenge

Antiallergic effect of the atomized extract of rhizome of <em>Curcuma longa</em>, flowers of <em>Cordia lutea</em> and leaves of <em>Annona muricata</em>

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